Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Schaub, Franz X., Dhankani, Varsha, Berger, Ashton C., Trivedi, Mihir, Richardson, Anne B., Shaw, Reid, Zhao, Wei, Zhang, Xiaoyang +733 more·2018·Cell Systems
DOI 10.1016/j.cels.2018.03.003

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  25. MYCN reprograms postnatal cells toward embryonic-like transcriptional states and drives tumorigenesis
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  26. An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.
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  28. Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300
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  29. MYC/MAX balance dictates cell progenitor fate by altering the HOX program in the Drosophila eye
    Sara Monticelli, Giorgio Milazzo, Suleman Khan Zadran, Martina Santulli, Nicola Balboni, Silvia Strocchi, Ettore De Giorgio, Pieter Mestdagh, Angela Giangrande, Roberto Bernardoni et al. · 2026 · Frontiers in Cell and Developmental Biology
  30. BindingDB Entry 50014470: Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
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  31. BindingDB Entry 50021153: MYC the oncogene from hell: Novel opportunities for cancer therapy.
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  32. BindingDB Entry 50018504: Targeting MYC: From understanding its biology to drug discovery.
    BindingDB · 2024 · UC San Diego
  33. BindingDB Entry 50020536: Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers.
    BindingDB · 2024 · UC San Diego
  34. BindingDB Entry 50014910: Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
    BindingDB · 2023 · UC San Diego