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Cited by 172Celiac Disease Research and ManagementLiver Diseases and ImmunityLiver Disease and Transplantation

Celiac Disease and Risk of Liver Disease: A General Population-Based Study

Ludvigsson, Jonas F., Elfström, Peter, BroomÉ, Ulrika, Ekbom, Anders, Montgomery, Scott M.·2007·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2006.09.034
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Abstract

Background & aims Celiac disease (CD) is an important cause of hypertransaminasemia. CD might also be associated with severe forms of liver disease. We investigated the risk of liver disease in 13,818 patients with CD (1964-2003) and 66,584 age- and sex-matched reference individuals from a general population cohort.Methods We used Cox regression to estimate hazard ratios (HRs) for later liver disease and conditional logistic regression to estimate the risk of CD in individuals with liver disease before study entry.Results CD was associated with an increased risk of acute hepatitis (HR, 5.21; 95% confidence interval [CI], 1.88-14.40; P = .001), chronic hepatitis (HR, 5.84; 95% CI, 2.89-11.79; P < .001), primary sclerosing cholangitis (HR, 4.46; 95% CI, 2.50-7.98; P < .001), fatty liver (HR, 6.06; 95% CI, 1.35-27.16; P = .018), liver failure (HR, 3.30; 95% CI, 2.22-4.88; P < .001), liver cirrhosis or liver fibrosis (HR, 2.23; 95% CI, 1.34-3.72; P < .001), and primary biliary cirrhosis (HR, 10.16; 95% CI, 2.61-39.49; P < .001). There was no increased risk of liver transplantation (HR, 1.07; 95% CI, 0.12-9.62; P = .954). Adjustment for socioeconomic index or diabetes mellitus had no notable effect on the risk estimates. Prior liver disease was associated with a statistically significant 4-fold to 6-fold increased risk of later CD.Conclusion This study suggests that individuals with CD are at increased risk of both prior and subsequent liver disease.

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  • The same metabolic syndrome pathway occurs in periodontitis, psoriasis, celiac disease, obesity, COPD, and rheumatoid arthritis.

    “The same pathway has also been shown to occur in paraodontitis,118 psoriasis,119 celiac disease,120 obesity,121, 122 COPD,123, 124 and rheumatoid arthritis.125”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [120]

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Authors
Ludvigsson, J. F., Elfström, P., BroomÉ, U., Ekbom, A., & Montgomery, S. M.
Affiliations
  • Karolinska University Hospital (SE)
  • Örebro University Hospital (SE)
Corresponding author
Ludvigsson, Jonas F.
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2007-01
Volume
5
Issue
1
Pages
63-69.e1
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2006.09.034
OpenAlex
W2007102572
Cited by
172
References
41
Citations by year
2026: 3 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 7 · 2013: 14 · 2012: 6
FWCI
7.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
celiac disease, liver disease, liver cirrhosis, liver fibrosis, primary sclerosing cholangitis, primary biliary cirrhosis, hepatic steatosis, liver failure, acute hepatitis, chronic hepatitis, liver transplantation, elevated liver enzymes, disease risk
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Celiac Disease, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Liver Diseases, Male, Middle Aged, Prospective Studies, Registries, Sweden, Cholangitis, Sclerosing, Logistic Models, Proportional Hazards Models, Case-Control Studies, Risk Assessment

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