Increased risk of non-alcoholic fatty liver disease after diagnosis of celiac disease
Open accessAbstract
Background & aims Non-alcoholic fatty liver disease is a common cause of chronic liver disease. Celiac disease alters intestinal permeability and treatment with a gluten-free diet often causes weight gain, but so far there are few reports of non-alcoholic fatty liver disease in patients with celiac disease.Methods Population-based cohort study. We compared the risk of non-alcoholic fatty liver disease diagnosed from 1997 to 2009 in individuals with celiac disease (n = 26,816) to matched reference individuals (n = 130,051). Patients with any liver disease prior to celiac disease were excluded, as were individuals with a lifetime diagnosis of alcohol-related disorder to minimize misclassification of non-alcoholic fatty liver disease. Cox regression estimated hazard ratios for non-alcoholic fatty liver disease were determined.Results During 246,559 person-years of follow-up, 53 individuals with celiac disease had a diagnosis of non-alcoholic fatty liver disease (21/100,000 person-years). In comparison, we identified 85 reference individuals diagnosed with non-alcoholic fatty liver disease during 1,488,413 person-years (6/100,000 person-years). This corresponded to a hazard ratio of 2.8 (95% CI 2.0-3.8), with the highest risk estimates seen in children (HR = 4.6; 95% CI 2.3-9.1). The risk increase in the first year after celiac disease diagnosis was 13.3 (95% CI 3.5-50.3) but remained significantly elevated even beyond 15 years after the diagnosis of celiac disease (HR = 2.5; 95% CI 1.0-5.9).Conclusion Individuals with celiac disease are at increased risk of non-alcoholic fatty liver disease compared to the general population. Excess risks were highest in the first year after celiac disease diagnosis, but persisted through 15 years after diagnosis with celiac disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Individuals with celiac disease, characterized by increased gut permeability, are at increased risk of NAFLD compared to the general population.
“It has been also shown that individuals with celiac disease, characterized by increased gut permeability, are at increased risk of NAFLD compared to the general population [296,297].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [297]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
External review and validation of the Swedish national inpatient register
Ludvigsson, J. F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.-L., Reuterwall, C., Heurgren, M., & Olausson, P. O. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-450 · Cited by 5,055 · see citing works
Self-citationSteatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285 · see citing works
Vernon, G. C., Baranova, A. V., & Younossi, Z. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04724.x · Cited by 3,067 · see citing works
The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research
Ludvigsson, J. F., Otterblad-Olausson, P., Pettersson, B. U., & Ekbom, A. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9350-y · Cited by 2,407 · see citing works
Self-citationPowell, E. E., Cooksley, G. W. E., Hanson, R., Searle, J., Halliday, J. W., & Powell, L. W. (1990) · Hepatology · doi:10.1002/hep.1840110114 · Cited by 1,473 · see citing works
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
Miele, L., Valenza, V., La Torre, G., Montalto, M., Cammarota, G., Ricci, R., Mascianà, R., Forgione, A., Gabrieli, M. L., Perotti, G., et al. (2009) · Hepatology · doi:10.1002/hep.22848 · Cited by 1,434 · see citing works
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
Promrat, K., Kleiner, D. E., Niemeier, H. M., Jackvony, E., Kearns, M., Wands, J. R., Fava, J. L., & Wing, R. R. (2010) · Hepatology · doi:10.1002/hep.23276 · Cited by 1,330 · see citing works
Wigg, A. J., Roberts-Thomson, I. C., Dymock, R. B., McCarthy, P. J., Grose, R. H., & Cummins, A. G. (2001) · Gut · doi:10.1136/gut.48.2.206 · Cited by 836 · see citing works
Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing
Mohler, K. M., Sleath, P. R., Fitzner, J. N., Cerretti, D. P., Alderson, M. R., Kerwar, S. S., Torranee, D. S., Otten-Evans, C., Greenstreet, T. A., Weerawarna, K., et al. (1994) · Nature · doi:10.1038/370218a0 · Cited by 588 · see citing works
Health at a Glance: Europe 2010
OECD, & Union, E. (2010) · Health at a glance. Europe · doi:10.1787/health_glance-2010-en · Cited by 535 · see citing works
World Gastroenterology Organisation Global Guidelines
LaBrecque, D. R., Abbas, Z., Anania, F. A., Ferenci, P., Khan, A. G., Goh, K., Hamid, S. S., Va, I., Lizarzábal, M., Peñaranda, M. M., et al. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000116 · Cited by 520 · see citing works
Caldwell, S. H., & Crespo, D. M. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.02.013 · Cited by 499 · see citing works
Small-Intestinal Histopathology and Mortality Risk in Celiac Disease
Ludvigsson, J. F. (2009) · JAMA · doi:10.1001/jama.2009.1320 · Cited by 361 · see citing works
Self-citationCauses of Death in Patients With Celiac Disease in a Population-Based Swedish Cohort
Peters, U., Askling, J., Gridley, G., Ekbom, A., & Linet, M. S. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1566 · Cited by 281 · see citing works
Volynets, V., Küper, M. A., Strahl, S., Maier, I. B., Spruss, A., Wagnerberger, S., Königsrainer, A., Bischoff, S. C., & Bergheim, I. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2112-9 · Cited by 268 · cited 1× · see citing works
“Levels of endotoxin (lipopolysaccharide), derived from intestinal Gramnegative microbiota, are elevated in the sera of adults [15] and children [16] with NAFLD, suggesting these individuals have increased intestinal permeability.”
BackgroundRubio‐Tapia, A., & Murray, J. A. (2007) · Hepatology · doi:10.1002/hep.21949 · Cited by 218 · see citing works
Walker, M. M., Murray, J. A., Ronkainen, J., Aro, P., Storskrubb, T., D’Amato, M., Lahr, B. D., Talley, N. J., & Agréus, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.007 · Cited by 216 · see citing works
Brown, I., Mino-Kenudson, M. A., Deshpande, V., & Lauwers, G. Y. (2006) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2006-130-1020-iliapp · Cited by 192 · see citing works
Giorgio, V., Miele, L., Principessa, L., Ferretti, F., Villa, M. P., Negro, V., Grieco, A., Alisi, A., & Nobili, V. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.02.010 · Cited by 188 · see citing works
Patton, H. M., Yates, K. P., Ünalp–Arida, A., Behling, C. A., Huang, T. T. ‐., Rosenthal, P. J., Sanyal, A. J., Schwimmer, J. B., & Lavine, J. E. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.152 · Cited by 185 · see citing works
Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers
Ludvigsson, J. F., Brandt, L., Montgomery, S., Granath, F. N., & Ekbom, A. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-19 · Cited by 182 · see citing works
Self-citationvan Elburg, R. M., Uil, J. J., Mulder, C. J. J., & Heymans, H. S. A. (1993) · Gut · doi:10.1136/gut.34.3.354 · Cited by 179 · see citing works
Comparison between nonalcoholic steatohepatitis and alcoholic hepatitis.
Itoh, S., Yougel, T., & Kawagoe, K. (1987) · PubMed · Cited by 176 · see citing works
Celiac Disease and Risk of Liver Disease: A General Population-Based Study
Ludvigsson, J. F., Elfström, P., BroomÉ, U., Ekbom, A., & Montgomery, S. M. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.09.034 · Cited by 172 · see citing works
Self-citationBody Mass Index in Celiac Disease
Cheng, J., Brar, P. S., Lee, A. R., & Green, P. H. R. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181b7ed58 · Cited by 166 · see citing works
Self-citationIntestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis
Heyman, M., Abed, J., Lebreton, C., & Cerf–Bensussan, N. (2011) · Gut · doi:10.1136/gutjnl-2011-300327 · Cited by 162 · see citing works
Alisi, A., Manco, M., Vito, R. D., Piemonte, F., & Nobili, V. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181c7bdf1 · Cited by 147 · see citing works
Barshop, N. J., Sirlin, C. B., Schwimmer, J. B., & Lavine, J. E. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03703.x · Cited by 145 · see citing works
Celiac Disease in Normal‐weight and Overweight Children
Reilly, N. R., Aguilar, K. M., Hassid, B. G., Cheng, J., DeFelice, A. R., Kazlow, P. G., Bhagat, G., & Green, P. H. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182276d5e · Cited by 136 · see citing works
Self-citationRubio‐Tapia, A., Barton, S. H., Rosenblatt, J. E., & Murray, J. A. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181557e67 · Cited by 115 · see citing works
Socioeconomic position and education in patients with coeliac disease
Olén, O., Bihagen, E., Rasmussen, F. E., & Ludvigsson, J. F. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.01.006 · Cited by 102 · see citing works
Self-citationSymptoms and signs in individuals with serology positive for celiac disease but normal mucosa
Ludvigsson, J. F., Brandt, L., & Montgomery, S. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-57 · Cited by 100 · see citing works
Self-citationLuminal Bacteria and Small-Intestinal Permeability
Riordan, S. M., McIver, C. J., Thomas, D. H., Duncombe, V. M., Bolin, T. D., & Thomas, M. C. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709025099 · Cited by 95 · see citing works
Searching for coeliac disease in patients with non-alcoholic fatty liver disease
Bardella, M. T., Valenti, L., Pagliari, C., Peracchi, M., Farè, M., Fracanzani, A. L., & Fargion, S. (2004) · Digestive and Liver Disease · doi:10.1016/j.dld.2004.01.012 · Cited by 92 · see citing works
Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets
Norsa, L. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i34.5658 · Cited by 83 · see citing works
Coeliac disease and body mass index: A study of two Swedish general population-based registers
Olén, O., Montgomery, S., Marcus, C., Ekbom, A., & Ludvigsson, J. F. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903132013 · Cited by 81 · see citing works
Self-citationCoeliac disease and risk of tuberculosis: a population based cohort study
Ludvigsson, J. F., Wahlstrom, J., Grünewald, J., Ekbom, A., & Montgomery, S. (2006) · Thorax · doi:10.1136/thx.2006.059451 · Cited by 69 · see citing works
Self-citationBhat, G. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i7.209 · Cited by 65 · see citing works
Non-Alcoholic Steatohepatitis Occurs in Celiac Disease and is Associated with Cellular Stress
Kälsch, J., Bechmann, L. P., Manka, P. P., Kahraman, A., Schlattjan, M., Marth, T., Rehbehn, K.-U., Baba, H. A., & Canbay, A. E. (2013) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0032-1330421 · Cited by 60 · see citing works
Kabbani, T. A., Kelly, C. P., Betensky, R. A., Hansen, J., Pallav, K., Villafuerte-Gálvez, J., Vanga, R. R., Mukherjee, R., Novero, A., Dennis, M. D., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.033 · Cited by 50 · see citing works
Margariti, A., Deutsch, M. J., Manolakopoulos, S., TINIAKOS, D. G., & Papatheodoridis, G. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31826be328 · Cited by 47 · see citing works
Risk of tuberculosis in a large sample of patients with coeliac disease - a nationwide cohort study
Ludvigsson, J. F., Sanders, D. S., Maeurer, M. J., Jonsson, J., Grünewald, J., & Wahlström, J. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04572.x · Cited by 43 · see citing works
Self-citationA pathogenetic link between non-alcoholic fatty liver disease and celiac disease
Abenavoli, L., Milić, N., LORENZO, A. D., & Luzza, F. (2012) · Endocrine · doi:10.1007/s12020-012-9731-y · Cited by 35 · see citing works
The prevalence of celiac disease among patients with non-alcoholic fatty liver disease in Iran
Rahimi, A. R. O., Daryani, N. E., Ghofrani, H., Taher, M., Pashaei, M. R., Abdollahzade, S., KALANI, M., & Ajdarkosh, H. (2011) · The Turkish Journal of Gastroenterology · doi:10.4318/tjg.2011.0216 · Cited by 33 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [39]Ludvigsson JF Brandt L Montgomery SM Granath F Ekbom A Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers BMC Gastroenterol 2009 9 19 19284576 PMC2664822
Cited by
Sorted by citations
Celiac disease: a comprehensive current review
Caio, G., Volta, U., Sapone, A., Leffler, D. A., GIORGIO, R. D., Catassi, C., & Fasano, A. (2019) · BMC Medicine · doi:10.1186/s12916-019-1380-z · Cited by 1,114 · see citing works
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674 · see citing works
ESPEN practical guideline: clinical nutrition in liver disease
Bischoff, S. C., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Plauth, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.001 · Cited by 383 · see citing works
Therrien, A., Kelly, C. P., & Silvester, J. A. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001267 · Cited by 176 · see citing works
Raiteri, A., Granito, A., Giamperoli, A., Catenaro, T., Negrini, G., & Tovoli, F. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i1.154 · Cited by 150 · see citing works
Diagnosis and management of secondary causes of steatohepatitis
Liebe, R., Esposito, I., Bock, H. H., Dahl, S. V., Stindt, J., Baumann, U., Luedde, T., & Keitel, V. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.045 · Cited by 108 · see citing works
Guidelines for best practices in monitoring established coeliac disease in adult patients
Elli, L., Leffler, D. A., Cellier, C., Lebwohl, B., Ciacci, C., Schümann, M., Lundin, K. E. A., Zammit, S. C., Sidhu, R., Roncoroni, L., et al. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00872-2 · Cited by 109 · see citing works
Self-citationRecent strategies for tackling the problems in gluten-free diet and products
Demirkesen, İ., & Özkaya, B. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1823814 · Cited by 98 · see citing works
Almeida, N. E. C., Vanga, R. R., Theethira, T. G., Rubio‐Tapia, A., Murray, J. A., Villafuerte-Gálvez, J., Bonder, A., Mukherjee, R., Hansen, J., Dennis, M. D., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.192 · Cited by 81 · see citing works
Tovoli, F., Negrini, G., Farì, R., Guidetti, E., Faggiano, C., Napoli, L., Bolondi, L., & Granito, A. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14910 · Cited by 79 · see citing works
Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH
Svegliati-Baroni, G., Patrício, B., Lioci, G., Macedo, M. P., & Gastaldelli, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165820 · Cited by 66 · see citing works
Liver involvement in pediatric celiac disease
Anania, C., Luca, E. D., Castro, G. D., Chiesa, C., & Pacifico, L. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i19.5813 · Cited by 66 · see citing works
Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver
Agarwal, A. K., Singh, A., Mehtab, W., Gupta, V., Chauhan, A. K., Rajput, M. S., Singh, N., Ahuja, V., & Makharia, G. K. (2020) · Intestinal Research · doi:10.5217/ir.2019.00136 · Cited by 65 · see citing works
Marciano, F., Savoia, M., & Vajro, P. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.11.013 · Cited by 65 · see citing works
Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications
Hoffmanová, I., Sánchez, D., Tučková, L., & Tlaskalová‐Hogenová, H. (2018) · Nutrients · doi:10.3390/nu10070892 · Cited by 65 · see citing works
Review article: Follow‐up of coeliac disease
Tye–Din, J. A. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16847 · Cited by 58 · see citing works
Nakatsuka, A., Matsuyama, M., Yamaguchi, S., Katayama, A., Eguchi, J., Murakami, K., Teshigawara, S., Ogawa, D., Wada, N., Yasunaka, T., et al. (2016) · Scientific Reports · doi:10.1038/srep21721 · Cited by 58 · see citing works
Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders
Valvano, M., Longo, S. A., Stefanelli, G., Frieri, G., Viscido, A., & Latella, G. (2020) · Nutrients · doi:10.3390/nu12040940 · Cited by 56 · see citing works
Sourdough bread: A contemporary cereal fermented product
Sakandar, H. A., Hussain, R., Kubow, S. J., Sadiq, F. A., Huang, W., & Imran, M. (2019) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.13883 · Cited by 55 · see citing works
Felber, J., Schümann, M., Bläker, H., Fischbach, W., Koletzko, S., Laass, M. W., Lachmann, N., Lorenz, P., Lynen, P., Reese, I., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1741-5946 · Cited by 54 · see citing works
Rubio‐Tapia, A., & Murray, J. A. (2019) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.12.001 · Cited by 52 · see citing works
Sen, P., Carlsson, C., Virtanen, S. M., Simell, S., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M., et al. (2019) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000044 · Cited by 48 · see citing works
Cardiometabolic risk factors in children with celiac disease on a gluten-free diet
Anania, C., Pacifico, L., Olivero, F., Perla, F. M., & Chiesa, C. (2017) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v6.i3.143 · Cited by 44 · see citing works
Nonalcoholic fatty liver disease (NAFLD): Diagnosis, pitfalls, and staging
Koch, L. K., & Yeh, M. M. (2018) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2018.09.009 · Cited by 43 · see citing works
Non-alcoholic fatty liver disease: A review with clinical and pathological correlation
Chen, Y., & Yeh, M. M. (2020) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2020.07.006 · Cited by 39 · see citing works
Pediatric Nonalcoholic Fatty Liver Disease
Nobili, V., & Socha, P. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001823 · Cited by 36 · see citing works
Adams, L. C., Lübbe, F., Bressem, K. K., Wagner, M., Hamm, B., & Makowski, M. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206450 · Cited by 36 · see citing works
Celiac Disease and Elevated Liver Enzymes: A Review
Kim, J. V., & Wu, G. Y. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00089 · Cited by 37 · see citing works
Yuan, S., Jiang, F., Chen, J., Lebwohl, B., Green, P. H. R., Leffler, D. A., Larsson, S. C., Li, X., & Ludvigsson, J. F. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105033 · Cited by 34 · see citing works
Self-citationTINIAKOS, D. G., Anstee, Q. M., & Burt, A. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00005-4 · Cited by 34 · see citing works
Laszkowska, M., Mahadev, S., Sundström, J., Lebwohl, B., Green, P. H. R., Michaëlsson, K., & Ludvigsson, J. F. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14911 · Cited by 34 · see citing works
Self-citationNon-alcoholic fatty liver disease severity is modulated by transglutaminase type 2
Piacentini, M., Baiocchini, A., Nonno, F. D., Melino, G., Barlev, N. A., Rossin, F., D’Eletto, M., & Falasca, L. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0292-8 · Cited by 32 · see citing works
Celiac Disease and Its Role in the Development of Metabolic Bone Disease
Micić, D., Rao, V. L., & Semrad, C. E. (2019) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2019.06.005 · Cited by 32 · see citing works
Coeliac disease and invasive pneumococcal disease: a population-based cohort study
Tjernberg, A. R., Bonnedahl, J., Inghammar, M., Egesten, A., Kahlmeter, G., Nauclér, P., Henriques‐Normark, B., & Ludvigsson, J. F. (2017) · Epidemiology and Infection · doi:10.1017/s0950268816003204 · Cited by 27 · see citing works
Self-citationAlternative Etiologies of Liver Disease in Children With Suspected NAFLD
Yodoshi, T., Orkin, S. H., Arce‐Clachar, A. C., Bramlage, K., Xanthakos, S. A., Valentino, P. L., & Mouzaki, M. (2021) · PEDIATRICS · doi:10.1542/peds.2020-009829 · Cited by 27 · see citing works
Laszkowska, M., Roy, A., Lebwohl, B., Green, P. H. R., Sundelin, H. E. K., & Ludvigsson, J. F. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2016.05.019 · Cited by 24 · see citing works
Self-citationTo screen or not to screen? Celiac antibodies in liver diseases
Narciso-Schiavon, J. L., & Schiavon, L. D. L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i5.776 · Cited by 24 · see citing works
Rinninella, E., Cintoni, M., Raoul, P. C., Triarico, S., Dionisi, T., Gasbarrini, G. B., Gasbarrini, A., & Mele, M. C. (2021) · Gastroenterology Insights · doi:10.3390/gastroent12020015 · Cited by 20 · see citing works
Hepatic Steatosis in Patients with Celiac Disease: The Role of Packaged Gluten-Free Foods
Raiteri, A., Granito, A., Faggiano, C., Giamperoli, A., Catenaro, T., Negrini, G., & Tovoli, F. (2022) · Nutrients · doi:10.3390/nu14142942 · Cited by 20 · see citing works
Celiac disease - a pluripathological model in pediatric practice
Lupu, V. V., Săsăran, M. O., Jechel, E., Stârcea, I. M., Ioniuc, I. K., Mocanu, A., Rosu, S. T., Münteanu, V., Nedelcu, A. H., Danielescu, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1390755 · Cited by 19 · see citing works
Coeliac disease: complications and comorbidities
Ludvigsson, J. F., Yao, J., Lebwohl, B., Green, P. H. R., Yuan, S., & Leffler, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-01032-w · Cited by 22 · see citing works
Self-citationCeliac Disease, Gluten-Free Diet and Metabolic Dysfunction-Associated Steatotic Liver Disease
Cazac, G.-D., Mihai, B. M., Ștefănescu, G., Gîlcă-Blanariu, G.-E., Mihai, C., Grigorescu, E.-D., Onofriescu, A., & Lăcătușu, C.-M. (2024) · Nutrients · doi:10.3390/nu16132008 · Cited by 18 · see citing works
The use of peripheral blood mononuclear cells in celiac disease diagnosis and treatment
Kurki, A., Kemppainen, E., Laurikka, P., Kaukinen, K., & Lindfors, K. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1850262 · Cited by 18 · see citing works
Advances in the pathophysiology, diagnosis, and management of celiac disease
Doyle, J. B., Silvester, J. A., Ludvigsson, J. F., & Lebwohl, B. (2025) · BMJ · doi:10.1136/bmj-2024-081353 · Cited by 19 · see citing works
Self-citationHepatobiliary phenotype of individuals with chronic intestinal disorders
Voss, J., Schneider, C. V., Kleinjans, M., Bruns, T., Trautwein, C., & Strnad, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-98843-7 · Cited by 17 · see citing works
Kamal, S. M., Aldossari, K. K., Ghoraba, D., Abdelhakam, S. M., Kamal, A. H., Bedewi, M. A., Nabegh, L., Bahnasy, K., & Hafez, T. A. (2018) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000150 · Cited by 16 · see citing works
MAFLD and Celiac Disease in Children
Scapaticci, S., Venanzi, A., Chiarelli, F., & Giannini, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021764 · Cited by 15 · see citing works
Metabolic-associated fatty liver disease and autoimmune hepatitis: an overlooked interaction
Gaber, Y., AbdAllah, M., Salama, A., Sayed, M. M., Alem, S. A., & Nafady, S. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1952867 · Cited by 12 · see citing works
Mortality and causes of death in different celiac disease phenotypes during long-term follow-up
Koskinen, I., Hervonen, K., Huhtala, H., Pasternack, C., Salmi, T. T., Reunala, T. L., Collin, P., & Kaukinen, K. (2022) · Digestive and Liver Disease · doi:10.1016/j.dld.2022.04.016 · Cited by 12 · see citing works
Extraintestinal complications of celiac disease: treatment considerations
Lazzano, P., Fracas, E., Nandi, N., Scaramella, L., & Elli, L. (2024) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2024.2443053 · Cited by 10 · see citing works
Influence of genetically predicted autoimmune diseases on NAFLD
Xu, M., Wu, T., Li, Z., & Xin, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1229570 · Cited by 10 · see citing works
Amrousy, D. M. E., El-Shehaby, W. A., Elsharaby, R. M., Badr, S., Hamza, M. B., & Elbarky, A. M. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-05343-z · Cited by 10 · see citing works
Nijhawan, S., & Goyal, G. (2015) · Journal of Gastrointestinal & Digestive System · doi:10.4172/2161-069x.1000350 · Cited by 9 · see citing works
Intestinal injury in the rat model of 17α‐ethynylestradiol‐induced intrahepatic cholestasis
Chang, M., Xu, Y., He, W., Zhang, C. L., Li, X. P., & Liu, D. (2016) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12407 · Cited by 8 · see citing works
Challenges to drug discovery for celiac disease and approaches to overcome them
Vaquero, L. M., Bernardo, D., León, F., Rodríguez‐Martín, L., Álvarez-Cuenllas, B., & Vivas, S. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1642321 · Cited by 8 · see citing works
Yuan, S., Leffler, D., Lebwohl, B., Green, P. H. R., Sun, J., Carlsson, S., Larsson, S. C., & Ludvigsson, J. F. (2024) · Diabetologia · doi:10.1007/s00125-024-06175-8 · Cited by 7 · see citing works
Self-citationFatty liver and celiac disease: Why worry?
Narciso-Schiavon, J. L., & Schiavon, L. D. L. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i5.666 · Cited by 7 · see citing works
Küçükseymen, S., Çekın, A. H., Bayar, N., Arslan, Ş., Uygur-Kucukseymen, E., Mercan, T., & Özdemir, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190382 · Cited by 7 · see citing works
Machado, M. V. (2020) · Hepatoma Research · doi:10.20517/2394-5079.2020.90 · Cited by 7 · see citing works
A Potential Role for Bile Acid Signaling in Celiac Disease-Associated Fatty Liver
Manka, P. P., Sydor, S., Schänzer, J., Brandenburg, M., Best, J., Vilchez‐Vargas, R., Link, A., Heider, D., Brodesser, S., Figge, A., et al. (2022) · Metabolites · doi:10.3390/metabo12020130 · Cited by 7 · see citing works
Prevalence of autoimmune, cholestatic and nonalcoholic fatty liver disease in celiac disease
Hitawala, A. A., Almomani, A., Onwuzo, S., Boustany, A., Kumar, P., & Asaad, I. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002599 · Cited by 7 · see citing works
Seidita, A., Latteri, F., Pistone, M., Giuliano, A., Bertoncello, L., Cavallo, G., Chiavetta, M., Faraci, F., Nigro, A., Termini, A., et al. (2024) · Nutrients · doi:10.3390/nu17010085 · Cited by 6 · see citing works
Yao, J., Sun, J., Ebrahimi, F., Bergman, D., Green, P. H. R., Hagström, H., Lebwohl, B., Leffler, D. A., & Ludvigsson, J. F. (2025) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2024.101201 · Cited by 6 · see citing works
Self-citationCardiovascular risk factors in coeliac disease (ARCTIC): a protocol of multicentre series of studies
Vereczkei, Z., Imrei, M., Szakács, Z., Kővári, B., Papp, V., Lénárt, Z., Berki, T., Szirmay, B., Farkas, N., Balaskó, M., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-068989 · Cited by 5 · see citing works
Mediterranean Diet Adherence in Celiac Patients: A Nested Cross-Sectional Study
Peresztegi, M. Z., Szakács, Z., Vereczkei, Z., Dakó, E., Dakó, S., Lada, S., Lemes, K., Holczer, M., Farkas, N., & Bajor, J. (2025) · Nutrients · doi:10.3390/nu17050788 · Cited by 6 · see citing works
Hastier, A., Patouraux, S., Canivet, C. M., Lebeaupin, C., Tran, A., & Anty, R. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.09.006 · Cited by 5 · see citing works
Body Mass Index during Gluten-Free Diet in Patients with Celiac Disease
Vereczkei, Z., Dergez, T., Fodor, Z., Szakács, Z., & Bajor, J. (2023) · Nutrients · doi:10.3390/nu15163517 · Cited by 5 · see citing works
Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease
Karlson, O., Arnell, H., Gudjónsdóttir, A. H., Agardh, D., & Naluai, Å. T. (2022) · BMC Medicine · doi:10.1186/s12916-022-02635-3 · Cited by 4 · see citing works
Renno, A. W., Abdel‐Aziz, Y., Alastal, Y., Khuder, S., Hasan, S., Assaly, R., & Nawras, A. T. (2021) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2021.104488 · Cited by 4 · see citing works
Pei, J., Wei, S., Pei, Y., Wu, H., & Wang, D. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190409120716 · Cited by 3 · see citing works
Dikker, O., & Dağ, H. (2019) · Medical Principles and Practice · doi:10.1159/000503633 · Cited by 3 · see citing works
Penny, H. A., Shiha, M. G., Raju, S. A., Nandi, N., Trott, N., Batlle, C. C., Whelan, J., Schiepatti, A., Andrews, C., Preest, G., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-337747 · Cited by 3 · see citing works
Self-citationNovel Insights to Celiac Disease: A review article
Pourtalebi-Firoozabadi, A., Mohamadian, M., Parsamanesh, N., Moossavi, M., & Naseri, M. (2016) · Research in Molecular Medicine · doi:10.18869/acadpub.rmm.4.2.1 · Cited by 2 · see citing works
Pitchumoni, C. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-30192-7_69 · Cited by 2 · see citing works
Risk of Drop-Out from Follow-Up Evaluations for Celiac Disease: Is It Similar for All Patients?
Tovoli, F., Faggiano, C., Raiteri, A., Giamperoli, A., Catenaro, T., Sansone, V., Pallotta, D. P., & Granito, A. (2022) · Nutrients · doi:10.3390/nu14061223 · Cited by 2 · see citing works
Schranz, M., Lucà, M. G., D’Antiga, L., & FAGIUOLI, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-96400-3_22 · Cited by 2 · see citing works
Cioni, G. (2018) · Polish Annals of Medicine · doi:10.29089/2017.17.00034 · Cited by 1 · see citing works
Cadenhead, J. W., Lee, A. R., Nguyen, T. T. T., Lebwohl, B., Green, P. H. R., & Wolf, R. L. (2024) · Nutrients · doi:10.3390/nu16183067 · Cited by 1 · see citing works
Self-citationTowards personalized microbial therapies for metabolic alterations in celiac disease
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Exploration of Digestive Diseases · doi:10.37349/edd.2025.100584 · Cited by 1 · see citing works
Forcina, G., Frattolillo, V., Cesare, M. D., Floriano, A., Palma, R., Casamassima, F., Bartiromo, M., Marzuillo, P., del Giudice, E. M., & Sessa, A. D. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2600386 · Cited by 1 · see citing works
Kaushalya, S. D. N., Wijesinghe, W. A. J. P., & Kim, E. (2025) · International Journal for Vitamin and Nutrition Research · doi:10.31083/ijvnr38564 · Cited by 1 · see citing works
Marxer, C. A., Ebrahimi, F., Bergman, D., Sun, J., Hagström, H., Thuresson, M., Stephansson, O., & Ludvigsson, J. F. (2026) · Scientific Reports · doi:10.1038/s41598-026-46246-x · Cited by 1 · see citing works
Self-citationÇÖLYAK HASTALIĞININ KARACİĞER TUTULUMLARI
Düzenli, T., & Tanoğlu, A. (2017) · Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi · doi:10.18017/iuitfd.363589 · Cited by 1 · see citing works
Celiac disease in Chilean adults
von Mühlenbrock, C., & Madrid-Silva, A. M. (2022) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2022.03.007 · Cited by 1 · see citing works
Assessment of Cardiac Functions in Children Suffering from Celiac Disease
Aslan, A. E., El-Shehaby, W. A., Eldein, A. M. B., Elsharaby, R. M., & Elbarky, A. M. (2023) · Asian Journal of Pediatric Research · doi:10.9734/ajpr/2023/v13i2260 · Cited by 1 · see citing works
Letter: Breaking new ground—Understanding the role of ATI‐free diet in managing MASLD
Spertino, M., Rossi, R. E., & Pugliese, N. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18064 · Cited by 1 · see citing works
Celiac Disease and Metabolic Diseases: A Review of Emerging Connections
Reidy, D., Cao, C., Rosenstock, A., Stoffels, M., Kumar, S. R., & Zylberberg, H. M. (2025) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-025-00471-x · Cited by 1 · see citing works
Non-dietary therapies for celiac disease
Yoosuf, S., Therrien, A., & Leffler, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821571-5.00011-8 · Cited by 1 · see citing works
Case 27-2023: A 53-Year-Old Woman with Celiac Disease and Upper Gastrointestinal Bleeding
Hashemi, N., Lopes, E. W., Dhami, R. S., Lin, A. E., & Moodley, J. (2023) · New England Journal of Medicine · doi:10.1056/nejmcpc2300903 · Cited by 1 · see citing works
Managing individuals with non-immune food hypersensitivity
Skypala, I. J., & Reese, I. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96018-2.00129-2 · Cited by 1 · see citing works
Fontanella, A., Nardi, R., Masina, M., & Uomo, G. (2017) · Italian Journal of Medicine · doi:10.4081/itjm.q.2017.7
Non alcoholic fatty liver disease in a young male with celiac disease
Majid, Z., Somoro, G. B., Haque, M. M. U., Yaseen, R. T., Khan, S. A., Achakzai, I. K., Khalid, M. A., & Luck, N. H. (2019) · Pan African Medical Journal · doi:10.11604/pamj.2019.32.25.16345
Bischoff, S. C., Bernal, W. E., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., Plauth, M., Скрипник, І. М., & Shvets, O. (2021) · Modern Gastroenterology · doi:10.30978/mg-2021-1-59
INTESTINAL GLUCONEOGENESIS IS DOWNREGULATED IN PAEDIATRIC PATIENTS WITH COELIAC DISEASEPreprint
Karlson, O., Arnell, H., Gudjónsdóttir, A. H., Agardh, D., & Naluai, Å. T. (2021) · medRxiv · doi:10.1101/2021.09.08.21262795
Holmes, G. K. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821846-4.00004-8
Pitchumoni, C. S. (2020) · Springer eBooks · doi:10.1007/978-3-319-90761-1_69-1
Enfermedad celiaca en adultos chilenos
von Mühlenbrock, C., & Madrid-Silva, A. M. (2022) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2021.04.009
Patel, P., & Micić, D. (2022) · Springer eBooks · doi:10.1007/978-3-030-94953-2_6
Research Progress on Inflammatory Bowel Disease Complicated with Non-Alcoholic Fatty Liver Disease
马, 有. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1361327
Nonalcoholic Fatty Liver Disease Within Other Causes of Chronic Liver Diseases
Gheorghe, L. S., & Iacob, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-33548-8_12
- Authors
- Reilly, N. R., Lebwohl, B., Hultcrantz, R., Green, P. H. R., & Ludvigsson, J. F.
- Affiliations
- Columbia University Irving Medical Center (US)
- Karolinska Institutet (SE)
- Örebro University (SE)
- Corresponding author
- Ludvigsson, Jonas F.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 62
- Issue
- 6
- Pages
- 1405-1411
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC4439270
- OpenAlex
- W2089313045
- Cited by
- 110
- References
- 44
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 4 · 2015: 5
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000040, KL2TR001874)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- non-alcoholic fatty liver disease, celiac disease, gluten-free diet, intestinal permeability, weight gain, chronic liver disease, children
- MeSH terms
- Adolescent, Adult, Aged, Celiac Disease, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Sweden, Time Factors, Cohort Studies, Young Adult, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
