The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Serologic Profiles Aiding the Diagnosis of Autoimmune Gastrointestinal Dysmotility
Open accessAbstract
Background & aims Autoimmune gastrointestinal dysmotility is a limited autoimmune dysautonomia occurring idiopathically or in the context of an anatomically remote neoplasm, previously documented or unsuspected. Here we report 24 Mayo Clinic patients in whom the profile of serum autoantibodies aided this diagnosis. Methods All patients were ascertained serologically in the course of service evaluation for autoantibodies consistent with neurologic autoimmunity. Review of their histories, motility studies, and laboratory findings revealed that all had presented with subacute gastrointestinal dysmotility. Results Recorded motility abnormalities included esophageal dysmotility 8 (6 had achalasia), delayed gastric emptying 12, slow small intestinal transit 7, slow colonic transit 4, and pelvic floor dyssynergia 4. Four patients underwent abdominal surgery; 2 commenced total parenteral nutrition. Plasma membrane cation channel autoantibodies were detected in 23 patients: neuronal voltage-gated calcium channel (5 N-type and 1 P/Q-type), acetylcholine receptor (11 ganglionic-type and 4 muscle-type), and neuronal voltage-gated potassium channel autoantibodies (4). Two patients had antineuronal nuclear autoantibodies, type 1. Approximately half of the patients had neural autoantibodies (including skeletal muscle striational and glutamic acid decarboxylase, 65kd isoform) or other antibody markers of organ-specific autoimmunity (thyroid or gastric parietal cell specificities). Neoplasia was diagnosed in 11 patients (9 recent, 2 remote): lung, breast and endometrial, gastrointestinal and thymoma. Moderate to dramatic improvement in gastrointestinal symptoms was reported after immunotherapy in 4 of 4 patients treated and after pyridostigmine treatment in 2 of 2 patients treated. Conclusions Autoimmune serology aids the diagnosis of autoimmune gastrointestinal dysmotility, both paraneoplastic and idiopathic, and might guide management.
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“In cohorts of patients with idiopathic, paraneoplastic, or diabetic autonomic neuropathy and in idiopathic GI dysmotility, ganglionic receptor-binding antibody titers have correlated with more severe autonomic dysfunction (Dhamija et al., 2008; Pittock et al., 2011).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Dhamija et al., 2008
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“Autoantibodies directed against specific neural antigens (including ion channels and ganglionic acetylcholine receptors) have been associated with esophageal dysmotility, slow-transit constipation, and chronic intestinal pseudo-obstruction.”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Dhamija et al., 2008
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Cites
Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431204 · Cited by 674
Self-citationCalcium-Channel Antibodies in the Lambert–Eaton Syndrome and Other Paraneoplastic Syndromes
Lennon, V. A., Kryzer, T. J., Griesmann, G. E., O’Suilleabhain, P. E., Windebank, A. J., Woppmann, A., Miljanich, G. P., & Lambert, E. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506013322203 · Cited by 595
Self-citationMyasthenia Gravis: A New Hypothesis
Simpson, J. A. (1960) · Scottish Medical Journal · doi:10.1177/003693306000501001 · Cited by 584
Lucchinetti, C. F., Kimmel, D. W., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.3.652 · Cited by 499
Self-citationParaneoplastic antibodies coexist and predict cancer, not neurological syndrome
Pittock, S. J., Kryzer, T. J., & Lennon, V. A. (2004) · Annals of Neurology · doi:10.1002/ana.20269 · Cited by 318
Self-citationInflammatory neuropathies of the enteric nervous system☆
GIORGIO, R. D., Guerrini, S., Barbara, G., Stanghellini, V., Ponti, F. D., Corinaldesi, R., Moses, P. L., Sharkey, K. A., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.024 · Cited by 303
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma
Lennon, V. A., Sas, D. F., Busk, M. F., Scheithauer, B., Malagelada, J.-R., Camilleri, M., & Miller, L. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90593-a · Cited by 250
Self-citationGlutamic Acid Decarboxylase Autoimmunity With Brainstem, Extrapyramidal, and Spinal Cord Dysfunction
Pittock, S. J., Yoshikawa, H., Ahlskog, J. E., Tisch, S. H., Benarroch, E. E., Kryzer, T. J., & Lennon, V. A. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.9.1207 · Cited by 231
Self-citationVernino, S. A., Adamski, J., Kryzer, T. J., Fealey, R. D., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.6.1806 · Cited by 226
Self-citationAutoantibody Profiles and Neurological Correlations of Thymoma
Vernino, S. A., & Lennon, V. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0735 · Cited by 200
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Research works printed but not linked: 2
- Kraicheley, 2007, Autoantibodies in primary achalasia, Neurogastroenterol Motil, 19, 425
- Kennelly, 1997, Neuronal autoantibodies and paraneoplastic neurological syndromes associated with extrapulmonary small cell carcinoma, Neurology, 48, A31
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Advances in the diagnosis and classification of gastric and intestinal motility disorders
on behalf of the International Working Group for Disorders of Gastrointestinal Motility and Function, Keller, J., Bassotti, G., Clarke, J. O., Dinning, P. G., Fox, M. R., Grover, M., Hellström, P. M., Ke, M., Layer, P., et al. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2018.7 · Cited by 273
Thymoma and paraneoplastic myasthenia gravis
Marx, A., Willcox, N., Leite, M. I., Chuang, W., Schalke, B. C. G., Nix, W. A., & Ströbel, P. (2010) · Autoimmunity · doi:10.3109/08916930903555935 · Cited by 223
Gastrointestinal motility disorders in neurologic disease
Camilleri, M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143771 · Cited by 211
Autoimmune Dementia: Clinical Course and Predictors of Immunotherapy Response
Flanagan, E. P., McKeon, A. B., Lennon, V. A., Boeve, B. F., Trenerry, M. R., Tan, K. M., Drubach, D. A., Josephs, K. A., Britton, J. W., Mandrekar, J. N., et al. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0326 · Cited by 182
Self-citationParaneoplastic encephalomyelopathies: pathology and mechanisms
McKeon, A. B., & Pittock, S. J. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0876-1 · Cited by 164
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Metadata
- Authors
- Dhamija, R., Tan, K. M., Pittock, S. J., Foxx–Orenstein, A., Benarroch, E., & Lennon, V. A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Lennon, Vanda A.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 6
- Issue
- 9
- Pages
- 988-992
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC2741093
- OpenAlex
- W2096265245
- Cited by
- 114
- References
- 24
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-68055, P01DK068055)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- autoantibodies, acetylcholine receptor antibodies, glutamic acid decarboxylase antibodies, achalasia, delayed gastric emptying, small intestinal transit, colonic transit, pelvic floor dyssynergia, paraneoplastic syndrome, esophageal motility, immunotherapy, pyridostigmine, thymoma
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Autoantibodies, Autoimmune Diseases, Autonomic Nervous System Diseases, Diagnosis, Differential, Female, Gastric Emptying, Gastrointestinal Motility, Gastrointestinal Transit, Humans, Immunotherapy, Intestinal Diseases, Male, Middle Aged, Neoplasms, Serologic Tests, Esophageal Motility Disorders
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