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Infection Control by Antibody Disruption of Bacterial Quorum Sensing Signaling
Open accessAbstract
Quorum sensing (QS) is the process through which bacteria communicate utilizing small diffusible molecules termed autoinducers. It has been demonstrated that QS controls a plethora of microbial processes including the expression of virulence factors. Here we report an immunopharmacotherapeutic approach for the attenuation of QS in the Gram-positive human pathogen Staphylococcus aureus. An anti-autoinducer monoclonal antibody, AP4-24H11, was elicited against a rationally designed hapten, and efficiently inhibited QS in vitro through the sequestration of the autoinducing peptide (AIP)-4 produced by S. aureus RN4850. Importantly, AP4-24H11 suppressed S. aureus pathogenicity in an abscess formation mouse model in vivo and provided complete protection against a lethal S. aureus challenge. These findings provide a strong foundation for further investigations of immunopharmacotherapy for the treatment of bacterial infections in which QS controls the expression of virulence factors.
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Cites
Cellular Control of the Synthesis and Activity of the Bacterial Luminescent System
Nealson, K. H., Platt, T., & Hastings, J. W. (1970) · Journal of Bacteriology · doi:10.1128/jb.104.1.313-322.1970 · Cited by 1,301
Cited by
Regulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Microbiologically influenced corrosion and current mitigation strategies: A state of the art review
Jia, R., Unsal, T., Xu, D., Lekbach, Y., & Gu, T. (2019) · International Biodeterioration & Biodegradation · doi:10.1016/j.ibiod.2018.11.007 · Cited by 503
Quorum-sensing regulation in staphylococci—an overview
Le, K. Y., & Otto, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01174 · Cited by 490
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Metadata
- Authors
- Park, J., Jagasia, R., Kaufmann, G. F., Mathison, J. C., Ruiz, D. I., Moss, J. A., Meijler, M. M., Ulevitch, R. J., & Janda, K. D.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 14
- Issue
- 10
- Pages
- 1119-1127
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2023138780
- Cited by
- 248
- References
- 1
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Park, J., Jagasia, R., Kaufmann, G. F., Mathison, J. C., Ruiz, D. I., Moss, J. A., Meijler, M. M., Ulevitch, R. J., & Janda, K. D. (2007). Infection Control by Antibody Disruption of Bacterial Quorum Sensing Signaling. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2007.08.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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