Cellular Control of the Synthesis and Activity of the Bacterial Luminescent System
Open accessAbstract
In bioluminescent bacteria growing in shake flasks, the enzyme luciferase has been shown to be synthesized in a relatively short burst during the period of exponential growth. The luciferase gene appears to be completely inactive in a freshly inoculated culture; the pulse of preferential luciferase synthesis which occurs later is the consequence of its activation at the level of deoxyribonucleic acid transcription which is attributed to an effect of a “conditioning” of the medium by the growing of cells. Although cells grown in a minimal medium also exhibit a similar burst of synthesis of the luminescent system, the amount of synthesis is quantitatively less, relative to cell mass. Under such conditions, added arginine results in a striking stimulation of bioluminescence. This is attributed to a stimulation of existing patterns of synthesis and not to induction or derepression per se.
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Prokaryotes communicate with each other through hormones and hormone-like compounds, a pattern called quorum sensing.
“Similarly to eukaryotes, prokaryotes communicate with each other through hormones and hormone-like compounds. This pattern of mutual bacterial inter action is called quorum sensing.41”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [41]
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- Authors
- Nealson, K. H., Platt, T., & Hastings, J. W.
- Affiliations
- Marine Biological Laboratory (US)
- ORCID
- Nealson, Kenneth H.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1970-10
- Volume
- 104
- Issue
- 1
- Pages
- 313-322
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC248216
- OpenAlex
- W1895584462
- Cited by
- 1,301
- References
- 8
- Citations by year
- 2026: 27 · 2025: 45 · 2024: 47 · 2023: 49 · 2022: 41 · 2021: 61 · 2020: 70 · 2019: 48 · 2018: 67 · 2017: 63 · 2016: 43 · 2015: 52 · 2014: 60 · 2013: 55 · 2012: 59
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › bioluminescence and chemiluminescence research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- bioluminescence, luciferase, gene expression regulation, transcriptional activation, exponential growth, minimal medium, arginine stimulation, derepression
- MeSH terms
- Aldehydes, Animals, Arginine, Chloramphenicol, Culture Media, Cyanides, Enzyme Induction, Light, Luciferases, Luminescent Measurements, Mutagens, Mutation, Photobacterium, Rabbits, Rifampin
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