Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

Mechanisms Underlying Ubiquitination

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Protein Modification by SUMO

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Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

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SUMO‐1 modification activates the transcriptional response of p53

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p300/CBP‐mediated p53 acetylation is commonly induced by p53‐activating agents and inhibited by MDM2

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Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1

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Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics

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Regulation of SUMOylation by Reversible Oxidation of SUMO Conjugating Enzymes

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The emerging field of dynamic lysine methylation of non-histone proteins

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Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor

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Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

Chhunchha, B., Singh, P., Singh, D. P., & Kubo, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113520 · Cited by 15

Pharmacological Activities of Ginkgolic Acids in Relation to Autophagy

Ding, Y. F., Ding, Z., Xu, J., Li, Y., & Chen, M. (2022) · Pharmaceuticals · doi:10.3390/ph15121469 · Cited by 15

The GTP-bound and Sumoylated Form of the rab17 Small Molecular Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic WIF-B Cells

Striz, A., & Tuma, P. L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.723353 · Cited by 15

Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis

Wang, X., Liu, T., Huang, Y., Dai, Y., & Lin, H. (2021) · Open Biology · doi:10.1098/rsob.210043 · Cited by 14

A Heck-Based Strategy To Generate Anacardic Acids and Related Phenolic Lipids for Isoform-Specific Bioactivity Profiling

Weigel, W. K., Dennis, T. N., Kang, A. S., Perry, J. J. P., & Martin, D. B. C. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b02705 · Cited by 14

p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells

Chowdhury, D., Singh, A. B., Gupta, A., Tulsawani, R., Meena, R. C., & Chakrabarti, A. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00974-4 · Cited by 13

Protective Effect of Curcuma Extract in an Ex Vivo Model of Retinal Degeneration via Antioxidant Activity and Targeting the SUMOylation

Hassanzadeh, K., Vahabzadeh, Z., Buccarello, L., Dragotto, J., Corbo, M., Maccarone, R., & Feligioni, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8923615 · Cited by 13

Identification of Sumoylation Inhibitors Targeting a Predicted Pocket in Ubc9

Kumar, A., Ito, A., Hirohama, M., Yoshida, M., & Zhang, K. Y. J. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci5004015 · Cited by 13

Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide

Zhou, L., Huang, X., Niesvizky, R., Pu, Z., & Xu, G. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000818 · Cited by 12

An In Vitro Förster Resonance Energy Transfer-Based High-Throughput Screening Assay for Inhibitors of Protein–Protein Interactions in SUMOylation Pathway

Song, Y., & Liao, J. (2011) · Assay and Drug Development Technologies · doi:10.1089/adt.2011.0394 · Cited by 13

A Novel Animal Model for Locally Advanced Breast Cancer

Bogachek, M. V., Park, J. M., Andrade, J. P. D., Kulak, M. V., White, J. R., Wu, T., Spanheimer, P. M., Bair, T., Olivier, A. K., & Weigel, R. J. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-4174-8 · Cited by 15

SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts

Martínez‐López, A., Infante, G., Mendiburu‐Eliçabe, M., Machuca, A., Antón, O. M., González‐Fernández, M., Luque-Garcia, J. L., Clarke, R. B., & Castillo‐Lluva, S. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01005-w · Cited by 12

Ginkgolic acid inhibits the expression of SAE1 and induces ferroptosis to exert an anti-hepatic fibrosis effect

Zhang, S., Liu, Z., Xia, T., Hao, W., Yang, R., Li, J., Du, G., Xu, Q., Jiang, Z., Liu, M., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155148 · Cited by 12

Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis

Parker, A. R., Forster, L. A., & Baro, D. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1379-18.2018 · Cited by 13

A novel cell-permeable peptide prevents protein SUMOylation and supports the mislocalization and aggregation of TDP-43

Marino, R., Buccarello, L., Hassanzadeh, K., Akhtari, K., Palaniappan, S., Corbo, M., & Feligioni, M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106342 · Cited by 11

The crosstalk between SUMOylation and immune system in host-pathogen interactions

Zhu, G., Tong, N., Zhu, Y., Wang, L., & Wang, Q. (2024) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2024.2339259 · Cited by 11

Novel insights into the impact of the SUMOylation pathway in hematological malignancies (Review)

Wang, L., Qian, J., Yang, Y., & Gu, C. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5253 · Cited by 11

Ginkgolic acid promotes inflammation and macrophage apoptosis via SUMOylation and NF-κB pathways in sepsis

Liu, X., Chen, L., Zhang, C., Dong, W., Liu, H., Xiao, Z., Wang, K., Zhang, Y., Tang, Y., Hong, G., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1108882 · Cited by 11

SUMOylation and related post-translational modifications in natural killer cell anti-cancer responses

Molfetta, R., Petillo, S., Cippitelli, M., & Paolini, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1213114 · Cited by 12

Four new ginkgolic acids from Ginkgo biloba

Deguchi, J., Hasegawa, Y., Takagi, A., Kutsukake, S., Kono, M., Hirasawa, Y., Wong, C. P., Kaneda, T., & Morita, H. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.05.076 · Cited by 11

Arsenic trioxide and angiotensin II have inhibitory effects on HERG protein expression: Evidence for the role of PML SUMOylation

Li, D., Nie, D., Nie, D., Liu, S.-K., Liu, M.-T., Li, Y., Li, Y.-Y., Wang, J., Liu, Y., Dong, C.-J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17563 · Cited by 11

Simultaneous quantification and semi-quantification of ginkgolic acids and their metabolites in rat plasma by UHPLC–LTQ–Orbitrap–MS and its application to pharmacokinetics study

Qian, Y., Zhu, Z., Duan, J., Guo, S., Shang, E., Tao, J., Su, S., & Guo, J. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.11.038 · Cited by 10

EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO

Barbeito, P., Martin-Morales, R., Palencia‐Campos, A., Cerrolaza, J., Rivas-Santos, C., Gallego-Colastra, L., Caparros-Martin, J. A., Martin-Bravo, C., Martín-Hurtado, A., Sánchez-Bellver, L., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1190258 · Cited by 10

Pharmacological treats for SUMO addicts

Licciardello, M. P., & Kubicek, S. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.004 · Cited by 12

Cross-talk between sumoylation and phosphorylation in mouse spermatocytes

Xiao, Y., Lucas, B., Molcho, E., & Vigodner, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.107 · Cited by 10

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation‐Inhibitory Activity

Nomura, Y., Thuaud, F., Sekine, D., Ito, A., Maeda, S., Koshino, H., Hashizume, D., Muranaka, A., Cruchter, T., Uchiyama, M., et al. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201901093 · Cited by 10

Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity

Chhunchha, B., Kubo, E., Kompella, U. B., & Singh, D. P. (2021) · Antioxidants · doi:10.3390/antiox10081245 · Cited by 10

Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases

Hua, D., & Wu, X. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114227 · Cited by 10

Sumoylation regulates functional properties of the oocyte transcription factors SOHLH1 and NOBOX

Patton, B. K., Madadi, S. R., Briley, S. M., Ahmed, A. A., & Pangas, S. A. (2023) · The FASEB Journal · doi:10.1096/fj.202201481r · Cited by 10

Exploring potential targets for natural product therapy of DN: the role of SUMOylation

Wang, J., Zhang, R., Wu, C., Wang, L., Liu, P., & Li, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1432724 · Cited by 10

Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells

Li, Z., Koch, K. E., Thompson, D. T., van der Heide, D. M., Chang, J., Franke, C. M., Suraju, M. O., Beck, A. C., Lorenzen, A. W., White, J. R., et al. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.04.005 · Cited by 9

SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma

Meng, F., Yuan, Y., Ren, H., Yue, H., Xu, B., & Qian, J. (2021) · Cancer Science · doi:10.1111/cas.15223 · Cited by 9

Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation

Huang, D., Zhao, D., Li, M., Chang, S.-Y., Xue, Y.-D., Xu, N., Li, S., Tang, N.-N., Gong, L.-L., Liu, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.76214 · Cited by 9

Novel mechanisms for the synthesis of important secondary metabolites in Ginkgo biloba seed revealed by multi-omics data

He, B., Qian, K., Han, X. H., Li, J., Zhou, Q. X., Xu, L., Liu, H., & Cui, P. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1196609 · Cited by 9

Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

Luck, M. I., Subillaga, E. J., Borenstein, R., & Sabo, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-58032-8 · Cited by 9

Protein sumoylation in normal and cancer stem cells

Zhu, Q., Liang, P., Chu, C., Zhang, A., & Zhou, W. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1095142 · Cited by 9

Identification of dihydroorotate dehydrogenase as a protein target of ginkgolic acid by molecular docking and dynamics

Yu, P., Li, D., Wang, L., Zhang, L., Cao, F., Fang, X., & Zhao, L. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.128692 · Cited by 9

In Vitro, In Vivo, and In Silico Activities of Ginkgolic Acid C15:1 against Streptococcus agalactiae Clinical Isolates

Wen, Z., Wang, C., Bai, B., Cao, X., Fan, K., Hu, C., Li, P., Deng, Q., & Yu, Z. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00188 · Cited by 8

A Simplein SituCell-Based SUMOylation Assay with Potential Application to Drug Screening

Muramatsu, M., Uwada, J., MATSUMOTO, N., & Saitoh, H. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100081 · Cited by 8

Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication

Wu, X., Hu, Y., Sui, C., Pan, L., Yoo, D., Miller, L. C., Lee, C., Cong, X., Li, J., Du, Y., et al. (2022) · Journal of Virology · doi:10.1128/jvi.00612-22 · Cited by 8

Inhibition of angiotensin I converting enzyme by anacardic acids isolated from Cashew nut ( Anacardium occidentale Linn.) shell liquid

Trevisan, M. T. S., Maia, I. R. D. O., dos Santos, S. J. M., Almeida, W. P., Ulrich, C. M., & Owen, R. W. (2018) · International Journal of Food Properties · doi:10.1080/10942912.2018.1460756 · Cited by 8

SUMO wrestling with Ras

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Unravelling the molecular interplay: SUMOylation, PML nuclear bodies and vascular cell activity in health and disease

Berkholz, J., & Karle, W. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111156 · Cited by 7

SARS-CoV-2 Nucleocapsid Protein Induces Tau Pathological Changes That Can Be Counteracted by SUMO2

Orsini, F., Bosica, M., Martucci, A., Paola, M. D., Comolli, D., Pascente, R., Forloni, G., Fraser, P. E., Arancio, O., & Fioriti, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137169 · Cited by 7

Natural Product Inhibitors of Ubiquitin Conjugation and Deconjugation

Hess, W., Mackeen, M. M., & Kramer, H. (2016) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63601-0.00006-5 · Cited by 7

Preparative Separation of Ginkgolic Acids from the Sarcotesta of Ginkgo biloba L. by β-Cyclodextrin Clathration Coupled with pH-Zone-Refining and Recycling Countercurrent Chromatography

Yan, H., Chen, L., Bai, A., Zhao, H., Kong, M., & Cui, L. (2018) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.8b04167 · Cited by 7

Ginkgolic Acid Inhibits Proliferation and Migration of Glioblastoma Cells by Inducing Cell Cycle Arrest and Apoptosis

Li, X., Liu, T., Chen, J., Alkhanjaf, A. A. M., & Zhang, D. (2021) · Science of Advanced Materials · doi:10.1166/sam.2021.4159 · Cited by 7

An in vitro Forster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9

Wang, Y., Liu, X., Way, G., Madarha, V., Zhou, Q., Yang, D., Liao, J., & Wang, M. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0405-7 · Cited by 7

PPAR Modulation Through Posttranslational Modification Control

Videira, N. B., Dias, M. M. G., Terra, M. F., de Oliveira, V. M., García‐Arévalo, M., Avelino, T. M., Torres, F. R., Batista, F. A. H., & Figueira, A. C. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-78315-0_21 · Cited by 7

A genetic screen to discover SUMOylated proteins in living mammalian cells

Komiya, M., Ito, A., Endo, M., Daisuke, H., Hattori, M., Saitoh, H., Yoshida, M., & Ozawa, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-17450-7 · Cited by 7

The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy

Jiaerken, B., Liu, W., Zheng, J., Qu, W., Wu, Q. Y., & Ai, Z. (2024) · Biomedicines · doi:10.3390/biomedicines12102408 · Cited by 6

UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis

Cai, J., Wei, J., Zeng, Y., Yi, M., Zhou, Y., Ai, K., Chen, W., Liu, Y., Chen, G., Chen, A., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.07.005 · Cited by 6

SUMOylation of the Cardiac Sodium Channel Na V 1.5 Modifies Inward Current and Cardiac Excitability

Yoon, J., Greiner, A. M., Jacobs, J. S., Kim, Y., Rasmussen, T. P., Kutschke, W. J., Matasic, D. S., Vikram, A., Gaddam, R. R., Mehdi, H., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2023.07.067 · Cited by 6

Epigenética nutricional: una pieza clave en el rompecabezas de la obesidad

Cordero, P., Milagro-Yoldi, F. I., Campión-Zabalza, J., & Martínez, J. A. (2010) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 6

Guanosine increases global SUMO1 ‐ylation in the hippocampus of young and aged mice and improves the short‐term memory of young mice

Zanella, C. A., Marques, N., Junqueira, S. C., Prediger, R. D., Tasca, C. I., & Cimarosti, H. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15920 · Cited by 6

Phytocompounds as modulators of HSF1 in neurodegenerative disease: Special emphasis on Alzheimer's disease

Nelson, V. K., Begum, M. Y., Dera, A. A., Ali, S. P., & Suryadevara, P. R. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178034 · Cited by 6

Develop quantitative FRET (qFRET) technology as a high-throughput universal assay platform for basic quantitative biomedical and translational research and development

Liao, J. (2023) · Med-X · doi:10.1007/s44258-023-00014-y · Cited by 5

Recent pharmacological insights on abating toxic protein species burden in neurological disorders: Emphasis on 26S proteasome activation

Desouky, M. A., Michel, H. E., Elsherbiny, D. A., & George, M. Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123206 · Cited by 5

SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy

Yan, S., Yuan, A., Shao, G.-C., Zhou, W., Xu, X., Dong, M., Liu, X., & Li, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110314 · Cited by 5

Mimicking/Extracting Structure and Functions of Natural Products: Synthetic Approaches that Address Unexplored Needs in Chemical Biology

Hirai, G. (2014) · The Chemical Record · doi:10.1002/tcr.201402074 · Cited by 5

Ginkgolic acid inhibits the replication of pseudorabies virus in vitro and in vivo by suppressing the transcription of viral late genes

Bo, Z., Wang, S., Li, X., Guo, M., Zhang, C., Cao, Y., Zhang, X., & Wu, Y. (2023) · Research in Veterinary Science · doi:10.1016/j.rvsc.2023.105033 · Cited by 5

Inhibition of protein SUMOylation by natural quinones

Fukuda, I., Hirohama, M., Ito, A., Tariq, M., Igarashi, Y., Saitoh, H., & Yoshida, M. (2016) · The Journal of Antibiotics · doi:10.1038/ja.2016.23 · Cited by 5

SUMOylation Modulates CFTR Biogenesis: Is the Pathway Druggable?

Ahner, A., & Frizzell, R. A. (2015) · Current Drug Targets · doi:10.2174/1389450116666150531152236 · Cited by 5

Dietary and Metabolic Compounds Affecting Covalent Histone Modifications

Milagro, F. I., & Martínez, J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805388-1.00020-1 · Cited by 4

The significance of SUMOylation of angiogenic factors in cancer progression

Wang, M., & Jiang, X. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1523854 · Cited by 5

Development of online-storage inner-recycling counter-current chromatography for the preparative separation of complex components of alkylphenols from sarcotesta of Ginkgo biloba L.

Wang, D., Song, X., Yan, H., Guo, M., Fu, R., Jiang, H., Zhu, H., & Wang, X. D. (2018) · RSC Advances · doi:10.1039/c8ra05618h · Cited by 5

Ginkgolic Acid (GA) Inhibits the Growth of OCa by Inhibiting lncRNA MALAT1/JAK2 Axis

Fei, Z., Yu, Y., Xiang, M., & Luo, F. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5481271 · Cited by 5

Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition

Leyva, M. J., Kim, Y. S., Peach, M. L., & Schneekloth, J. S. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.03.069 · Cited by 5

Identification of cell-biologic mechanisms of coronary artery spasm and its ex vivo diagnosis using peripheral blood-derived iPSCs

Yang, H., Lee, J., Kim, J., You, J., Kim, J., Lee, H. S., Yoo, H. M., Kong, M. G., Han, J., Cho, H., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00345-2 · Cited by 4

The role of SUMOylation in epithelial-mesenchymal transition

Li, S., Yu, X.-M., Liang, L., & Zheng, Y. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02568-3 · Cited by 4

Targeted inhibition of SUMOylation: treatment of tumors

Zhao, H., Zhao, P., & Huang, C. (2024) · Human Cell · doi:10.1007/s13577-024-01092-9 · Cited by 4

Expedient Synthesis of Anacardic Acid and Analogues by Suzuki–Miyaura Cross [C(sp2)‐C(sp3)] Coupling and Their Antidiabetic Action

Deevi, S. K., Anilkumar, B., Anilkumar, A., Kouser, S., Rajendran, S., Ramani, P., Vishnuprasad, C. N., Suma Mohan, S., & Nanjan, P. (2025) · ChemistrySelect · doi:10.1002/slct.202501742 · Cited by 4

Ginkgo biloba, DNA Damage and DNA Repair: Overview

de Oliveira, D. B., Johansson, B., & de Oliveira, R. P. S. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_11 · Cited by 4

SUMOylation balance: a key determinant in synapse physiology

Bertozzi, A., Toscanelli, W., Castellitto, G., Grassi, C., & Colussi, C. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1675598 · Cited by 3

Molecular Imaging Biosensor Monitors p53 Sumoylation in Cells and Living Mice

Sekar, T. V., Foygel, K., Devulapally, R., Kumar, V., Malhotra, S. V., Massoud, T. F., & Paulmurugan, R. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02048 · Cited by 3

SUMO Regulation of Ion Channels in Health and Disease

Connolly, J. G., & Plant, L. D. (2024) · Physiology · doi:10.1152/physiol.00034.2024 · Cited by 3

In Situ SUMOylation and DeSUMOylation Assays: Fluorescent Methods to Visualize SUMOylation and DeSUMOylation in Permeabilized Cells

Yuasa, E., & Saitoh, H. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6358-4_11 · Cited by 3

Leukemogenic kinase FIP 1L1‐ PDGFRA and a small ubiquitin‐like modifier E3 ligase, PIAS 1, form a positive cross‐talk through their enzymatic activities

Ibata, M., Iwasaki, J., Fujioka, Y., Nakagawa, K., Darmanin, S., Onozawa, M., Hashimoto, D., Ohba, Y., Hatakeyama, S., Teshima, T., et al. (2016) · Cancer Science · doi:10.1111/cas.13129 · Cited by 3

Application of targeted 2D planar chromatography in the control of ginkgolic acids in some herbal drugs and dietary supplements

Migas, P., Romańczuk, A., Szumacher, M., & Krauze‐Baranowska, M. (2020) · Acta Pharmaceutica · doi:10.2478/acph-2020-0004 · Cited by 3

The intricate relationship between SUMOylation and gliomas: a review with a perspective on natural compounds

Togni, A., Piermartiri, T., Tasca, C. I., & Nedel, C. B. (2025) · Natural Product Research · doi:10.1080/14786419.2025.2456093 · Cited by 2

Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell lines

Codenotti, S., Lauschke, V. M., Casella, E. V., Andersson, D. C., Fanzani, A., & Gastaldello, S. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05336-6 · Cited by 2

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL

Xiong, X., Zhi, Y., Yang, N., Zhao, W., Wang, S., Zhu, H., Tang, J. T., Yi, J., Sun, X., & Yang, J. (2025) · iScience · doi:10.1016/j.isci.2025.113067 · Cited by 2

Aging, oxidative stress, and cataracts: Therapeutic prospects and translational insights into peroxiredoxin 6

Kubo, E., Chhunchha, B., & Singh, D. P. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101444 · Cited by 3

SUMOylation Regulates BmNPV Replication by Moderating PKIP Intracellular Localization

Shen, R. D., Lü, D., Chen, G., Liu, M., Pu, S., Zhang, Y., Wang, Q., Qian, P., & Tang, X. (2022) · Processes · doi:10.3390/pr10020261 · Cited by 2

Topotecan and Ginkgolic Acid Inhibit the Expression and Transport Activity of Human Organic Anion Transporter 3 by Suppressing SUMOylation of the Transporter

Yu, Z., & You, G. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050638 · Cited by 2

Exploring the Role of Unconventional Post-Translational Modifications in Cancer Diagnostics and Therapy

Sharma, S., Sarkar, O., & Ghosh, R. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037274615240528113148 · Cited by 3

Ginkgo biloba, friend or foe of thyroid follicular cells of adult male albino rats

Solaiman, A. A., & Gazaerly, H. M. E. (2015) · The Egyptian Journal of Histology · doi:10.1097/01.ehx.0000473580.77475.b3 · Cited by 2

SUMO E1 covalent allosteric inhibitors modulate polyamine synthesis via the MAT2A-AdoMetDC axisPreprint

Zhang, S., Wang, Z., Jiao, Y., Shi, X., Ai, Y., Wang, J., & Liu, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.12.627095 · Cited by 2

Targeted DeSUMOylation as a therapeutic strategy for multiple sclerosis

Sriram, S., Kim, K. W., & Ljunggren‐Rose, A. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578371 · Cited by 1

Targeting SUMOylation with Anacardic Acid Derivatives: Novel Insights into EGF Pathway Dysregulation in Cancer Using an In Silico Approach

Padmakumar, S., Gopichand, B., Melge, A. R., Madhavan, A., Babu, P., Nair, B. G., Perry, J. J. P., & Kumar, G. B. (2025) · ACS Omega · doi:10.1021/acsomega.5c06377 · Cited by 1

Ginkgolic acid ameliorates pressure overload-induced cardiac remodeling by inhibiting SAE1 and activating the NRF2/HMOX1 pathway

Dang, X., Ji, Q., Huang, Z., Yang, N., Chi, C., Zhao, Y., Xu, Y., Wang, M., Liu, Y., Jiang, Z., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.034 · Cited by 1

Nervous necrosis virus capsid protein functions as a SUMO E3 ligase to activate MAVS-dependent NF-κB signaling

Zhang, W., Chen, X., Sun, B., Yao, L., Xiong, X., Yi, M., & Jia, K. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06155-8 · Cited by 1

Dietary Phytochemicals and Herbal Medicines Re‐Program Cellular Networks by Targeting Key Transcription Factors

Lindenmaier, M., & Stevens, J. F. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70457 · Cited by 1

Ginkgo biloba, DNA Damage and DNA Repair: Overview

de Oliveira, D. B., Johansson, B., & de Oliveira, R. P. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_11-1 · Cited by 1

Identification of SUMO activating enzyme 1 inhibitors utilizing virtual screening approach

Kumar, A., Ito, A., Hirohama, M., Yoshida, M., & Zhang, K. Y. J. (2014) · Journal of Cheminformatics · doi:10.1186/1758-2946-6-s1-p37 · Cited by 1

Polymorphism and Expression of HSD17β13 Gene and Its Association with Lamb Quality of Indonesian Sheep

Harahap, R. S., Noor, R. R., & Gunawan, A. (2021) · ANIMAL PRODUCTION · doi:10.20884/1.jap.2021.23.1.88 · Cited by 1

SUMOylation regulates protein cargo in Astrocyte-derived small extracellular vesiclesPreprint

Fernández, A., Méndez, M., Santis, O., Corvalán, K., Gomez, M.-T., Landgraf, P., Kähne, T., Rojas-Fernandez, A., & Wyneken, Ú. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.15.298554 · Cited by 1

Deletion of Small Ubiquitin-like Modifier-1 Attenuates Behavioral and Anatomical Deficits by Enhancing Functional Autophagic Activities in Huntington DiseasePreprint

Ramírez-Jarquín, U. N., Sharma, M., Shahani, N., & Subramaniam, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.15.431277 · Cited by 1

Pharmacologic Inhibition of Ubiquitin Activation as a Novel Therapeutic Strategy in Acute Myeloid Leukemia

Barghout, S. H. (2020) · TSpace (University of Toronto) · doi:10.13140/rg.2.2.10284.90246 · Cited by 1

Synthesis and Evaluation of Ginkgolic Acid Derivatives as SUMOylation Inhibitors

Brackett, C. M., García‐Casas, A., Castillo‐Lluva, S., & Blagg, B. S. J. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.0c00353 · Cited by 20

Inhibition of protein SUMOylation by natural quinones

Fukuda, I., Hirohama, M., Ito, A., Tariq, M., Igarashi, Y., Saitoh, H., & Yoshida, M. (2016) · The Journal of Antibiotics · doi:10.1038/ja.2016.23 · Cited by 5

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Takemoto, M., Kawamura, Y., Hirohama, M., Yamaguchi, Y., Handa, H., Saitoh, H., Nakao, Y., Kawada, M., Khalid, K., Koshino, H., et al. (2014) · The Journal of Antibiotics · doi:10.1038/ja.2013.142 · Cited by 62

Targeting SUMOylation with Anacardic Acid Derivatives: Novel Insights into EGF Pathway Dysregulation in Cancer Using an In Silico Approach

Padmakumar, S., Gopichand, B., Melge, A. R., Madhavan, A., Babu, P., Nair, B. G., Perry, J. J. P., & Kumar, G. B. (2025) · ACS Omega · doi:10.1021/acsomega.5c06377 · Cited by 1

Controlling protein SUMOylation

Schneekloth, J. S. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2496 · Cited by 7