Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

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SUMO and the robustness of cancer

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Signalling mechanisms and cellular functions of SUMO

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Monocyclic Phenolic Acids; Hydroxy- and Polyhydroxybenzoic Acids: Occurrence and Recent Bioactivity Studies

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Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

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The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment

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SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

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Biological activity of phenolic lipids

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Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

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SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

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SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs

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SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation

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SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

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Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

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Therapeutic strategies within the ubiquitin proteasome system

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Targeting SUMO Signaling to Wrestle Cancer

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Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

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c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

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DNA-Encoded Dynamic Chemical Library and Its Applications in Ligand Discovery

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ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment

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E1 Enzymes as Therapeutic Targets in Cancer

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Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2

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Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

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Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

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The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs

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Mammalian Su(var) Genes in Chromatin Control

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hnRNP K Coordinates Transcriptional Silencing by SETDB1 in Embryonic Stem Cells

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Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

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SUMOylation modification-mediated cell death

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GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism

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An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation

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Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype

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The main active constituents and detoxification process of Ginkgo biloba seeds and their potential use in functional health foods

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Sumoylation in Physiology, Pathology and Therapy

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Therapeutic Potential of Targeting the SUMO Pathway in Cancer

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CPEB3 inhibits translation of mRNA targets by localizing them to P bodies

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Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

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Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

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Anacardic Acid (6-Pentadecylsalicylic Acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway

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SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy

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Synthesis of 2′,3′,4′-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation

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Kerriamycin B inhibits protein SUMOylation

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Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

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Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas

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Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

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Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9

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Ginkgolic acid inhibits fusion of enveloped viruses

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Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways

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Ehrlichia chaffeensis Exploits Host SUMOylation Pathways To Mediate Effector-Host Interactions and Promote Intracellular Survival

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Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein–ligand recognition process

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SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

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SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses

Yao, Q., Li, H., Liu, B., Huang, X., & Guo, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220848 · Cited by 67

Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart Diseases

Hwang, J., Lee, A., & Kho, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095053 · Cited by 63

Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation

He, X., Riceberg, J., Pulukuri, S. M. K., Grossman, S., Shinde, V., Shah, P., Brownell, J. E., Dick, L. R., Newcomb, J. R., & Bence, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123882 · Cited by 65

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Takemoto, M., Kawamura, Y., Hirohama, M., Yamaguchi, Y., Handa, H., Saitoh, H., Nakao, Y., Kawada, M., Khalid, K., Koshino, H., et al. (2014) · The Journal of Antibiotics · doi:10.1038/ja.2013.142 · Cited by 62

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents

Cai, S., Moutal, A., Yu, J., Chew, L. A., Isensee, J., Chawla, R., Gómez, K., Luo, S., Zhou, Y., Chefdeville, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abh1314 · Cited by 61

The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death

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The antibacterial activity and mechanism of ginkgolic acid C15:1

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PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx

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Small-Molecule Inhibitors Targeting Protein SUMOylation as Novel Anticancer Compounds

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Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development

Usui, N., Co, M., Harper, M. J., Rieger, M. A., Dougherty, J. D., & Konopka, G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.008 · Cited by 59

SUMOylation in brain ischemia: Patterns, targets, and translational implications

Bernstock, J. D., Yang, W., Ye, D. G., Shen, Y., Pluchino, S., Lee, Y.-J., Hallenbeck, J. M., & Paschen, W. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17742260 · Cited by 58

Targeting the SUMO Pathway Primes All- trans Retinoic Acid–Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias

Baik, H., Boulanger, M., Hosseini, M., Kowalczyk, J., Zaghdoudi, S., Salem, T., Sarry, J., Hicheri, Y., Cartron, G., Piechaczyk, M., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3361 · Cited by 58

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme–CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

François‐Moutal, L., Dustrude, E. T., Wang, Y., Brustovetsky, T., Dorame, A., Ju, W., Moutal, A., Perez‐Miller, S., Brustovetsky, N., Gokhale, V. M., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001294 · Cited by 57

The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer

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Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes

Kung, C.-P., Khaku, S., Jennis, M., Zhou, Y., & Murphy, M. E. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0385 · Cited by 58

SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

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Viral manipulation of the cellular sumoylation machinery

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Foxp1 regulation of neonatal vocalizations via cortical developmentPreprint

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Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity

Hamdoun, S., & Efferth, T. (2017) · Oncotarget · doi:10.18632/oncotarget.16626 · Cited by 55

Posttranslational Modifications of α-Synuclein, Their Therapeutic Potential, and Crosstalk in Health and Neurodegenerative Diseases

Hassanzadeh, K., Liu, J., Maddila, S. C., & Mouradian, M. M. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.001111 · Cited by 56

IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation

Xia, P., Wang, S., Xiong, Z., Ye, B., Huang, L., Han, Z., & Fan, Z. (2015) · Nature Communications · doi:10.1038/ncomms9132 · Cited by 53

Melatonin disturbs SUMO ylation‐mediated crosstalk between c‐Myc and nestin via MT 1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells

Lee, H., Lee, H., Jung, J. H., Shin, E. A., & Kim, S. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12496 · Cited by 53

Natural Salicylates and Their Roles in Human Health

Yeasmin, F., & Choi, H. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239049 · Cited by 56

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

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SUMO targets the APC/C to regulate transition from metaphase to anaphase

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