The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Autophagy-Dependent Ferroptosis: Machinery and Regulation
Open accessAbstract
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular process capable of degrading various biological molecules (e.g., protein, glycogen, lipids, DNA, and RNA) and organelles (e.g., mitochondria, endoplasmic reticulum, ribosomes, lysosomes, and micronuclei) via the lysosomal pathway. Ferroptosis is a type of oxidative stress-dependent regulated cell death associated with iron accumulation and lipid peroxidation. The recently discovered role of autophagy, especially selective types of autophagy (e.g., ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy), in driving cells towards ferroptotic death motivated us to explore the functional interactions between metabolism, immunity, and cell death. Here, we describe types of selective autophagy and discuss the regulatory mechanisms and signaling pathways of autophagy-dependent ferroptosis. We also summarize chemical modulators that are currently available for triggering or blocking autophagy-dependent ferroptosis and that may be developed for therapeutic interventions in human diseases.
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1 retracted
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
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RetractedRegulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Self-citationAMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Self-citationLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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“At the same time, MAP1LC3-II can be degraded in a lysosome-dependent manner (Mizushima and Yoshimori, 2007; Pankiv et al., 2007).”
BackgroundACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Autophagy regulates lipid metabolism
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Cited by
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Self-citationAutophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Gao, W., Wang, X., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,042
Iron Metabolism in Ferroptosis
Chen, X., Yu, C., Kang, R., & Tang, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590226 · Cited by 959
Self-citationThe mechanism of HMGB1 secretion and release
Chen, R., Kang, R., & Tang, D. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00736-w · Cited by 849
Self-citationSignaling pathways and defense mechanisms of ferroptosis
Liu, J., Kang, R., & Tang, D. (2022) · The FEBS Journal · doi:10.1111/febs.16059 · Cited by 787
Self-citation
Metadata
- Authors
- Liu, J., Kuang, F., Kroemer, G., Klionsky, D. J., Kang, R., & Tang, D.
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 27
- Issue
- 4
- Pages
- 420-435
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W3012507702
- Cited by
- 812
- References
- 64
- FWCI
- 57.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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