The DOI matches its Crossref record; 244 of the 244 references it cites were found in a registry or an index.
The mechanism of HMGB1 secretion and release
Open accessAbstract
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 protein. After its active secretion or passive release, extracellular HMGB1 usually acts as a damage-associated molecular pattern (DAMP) molecule, regulating inflammation and immune responses through different receptors or direct uptake. The secretion and release of HMGB1 is fine-tuned by a variety of factors, including its posttranslational modification (e.g., acetylation, ADP-ribosylation, phosphorylation, and methylation) and the molecular machinery of cell death (e.g., apoptosis, pyroptosis, necroptosis, alkaliptosis, and ferroptosis). In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop new HMGB1-targeted drugs for various conditions, especially inflammatory diseases and tissue damage.
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1 retracted
Sitapara, R. A., Antoine, D. J., Sharma, L., Patel, V., Ashby, C. R., Gorasiya, S., Yang, H., Zur, M., & Mantell, L. L. (2014) · Molecular Medicine · doi:10.2119/molmed.2013.00086 · Cited by 50
RetractedOxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Intracellular Aspects of the Process of Protein Synthesis
Palade, G. (1975) · Science · doi:10.1126/science.1096303 · Cited by 3,564
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,385
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,253
Broadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 2,897
Self-citationActivation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884
The molecular machinery of regulated cell death
Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P., & Kroemer, G. (2019) · Cell Research · doi:10.1038/s41422-019-0164-5 · Cited by 2,549
Self-citationCho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435
Cited by
Chelko, S. P., Penna, V. R., Engel, M., Shiel, E. A., Centner, A. M., Farra, W., Cannon, E. N., Landim-Vieira, M., Schaible, N., Lavine, K., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172014 · Cited by 32
Sinusoidal communication in chronic liver disease
Gibert-Ramos, A., Andrés-Rozas, M., Pastó, R., Alfaro-Retamero, P., Guixé-Muntet, S., & Gracia-Sancho, J. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0734 · Cited by 20
Oza, D., Ivich, F., Deprey, K., Bittner, K., Bailey, K., Goldman, S., Yu, M., Niedre, M., Tu, H.-C., & Amiji, M. M. (2025) · ACS Nano · doi:10.1021/acsnano.4c18345 · Cited by 9
Emerging Roles of High-mobility Group Box-1 in Liver Disease
Wang, L., Dong, Z., Zhang, Y., & Peng, L. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2024.00317 · Cited by 8
Metadata
- Authors
- Chen, R., Kang, R., & Tang, D.
- Venue
- Experimental & Molecular Medicine
- Published
- 2022-02
- Volume
- 54
- Issue
- 2
- Pages
- 91-102
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W4214511313
- Cited by
- 849
- References
- 244
- FWCI
- 83.94
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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