Impact of Sludge Treatments on the Extractability and Fate of Acetyl Sulfamethoxazole Residues in Amended Soils
Open accessAbstract
Sludge recycled in agriculture may bring antibiotics into cropped soils. The nature, total amount, and availability of the antibiotics in soil partly depend on the sludge treatments. Our paper compares the fate of N-acetyl sulfamethoxazole (AC-SMX) residues between soils incubated with the same sludge but submitted to different processes before being added in soil. The fate of 14 C-AC-SMX residues was studied in mixtures of soil and sludges at different treatment levels: 1) activated and 2) centrifuged sludges, both enriched with 14 C-AC-SMX, and 3) limed and 4) heat-dried sludges obtained by treating the previously contaminated centrifuged sludge. The evolution of the extractability of 14 C residues (CaCl 2, methanol) and their mineralization were followed during 119 days. More than 80% of the initial 14 C-activity was no longer extractable after 14 days, except in soil with limed sludge. Liming and drying the centrifuged sludge decreased the mineralized 14 C fraction from 5.7-6.4% to 1.2-1.8% and consequently, the corresponding soils contained more 14 C residues after 119 days. Although 14 C residues were more CaCl 2-extractable in soil with limed sludge, they seemed to be poorly bioavailable for biodegradation. For all solid sludges, the mineralization rate of 14 C-AC-SMX residues was strongly correlated to that of sludge organic carbon, with a coefficient three times lower for the limed and dried sludges than for the centrifuged sludge after 14 days.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data
Boeckel, T. P. V., Gandra, S., Ashok, A., Caudron, Q., Grenfell, B. T., Levin, S. A., & Laxminarayan, R. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70780-7 · Cited by 2,285 · see citing works
Hu, X., Zhou, Q., & Luo, Y. (2010) · Environmental Pollution · doi:10.1016/j.envpol.2010.05.023 · Cited by 928 · see citing works
Chen, Q., An, X., Li, H., Su, J., Ma, Y., & Zhu, Y. (2016) · Environment International · doi:10.1016/j.envint.2016.03.026 · Cited by 830 · see citing works
Self-citationGöbel, A., Thomsen, A., McArdell, C. S., Joss, A., & Giger, W. (2005) · Environmental Science & Technology · doi:10.1021/es048550a · Cited by 760 · see citing works
Boreen, A. L., Arnold, W. A., & McNeill, K. (2004) · Environmental Science & Technology · doi:10.1021/es0353053 · Cited by 738 · see citing works
Excretion and ecotoxicity of pharmaceutical and personal care products in the environment
Jjemba, P. K. (2005) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2004.11.011 · Cited by 526 · see citing works
Verlicchi, P., & Zambello, E. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.08.108 · Cited by 500 · see citing works
Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review
Du, L., & Liu, W. (2011) · Agronomy for Sustainable Development · doi:10.1007/s13593-011-0062-9 · Cited by 465 · see citing works
Alvarenga, P., Mourinha, C., Farto, M., Santos, M. T., Palma, P., Sengo, J., Morais, M.-C., & Cunha‐Queda, C. (2015) · Waste Management · doi:10.1016/j.wasman.2015.01.027 · Cited by 457 · see citing works
Sorption of Sulfonamide Pharmaceutical Antibiotics on Whole Soils and Particle‐Size Fractions
Thiele‐Bruhn, S., Seibicke, T., Schulten, H. ‐., & Leinweber, P. (2004) · Journal of Environmental Quality · doi:10.2134/jeq2004.1331 · Cited by 413 · see citing works
Walters, E., McClellan, K., & Halden, R. U. (2010) · Water Research · doi:10.1016/j.watres.2010.07.051 · Cited by 369 · see citing works
Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks
Celiz, M. D., Tso, J., & Aga, D. S. (2009) · Environmental Toxicology and Chemistry · doi:10.1897/09-173.1 · Cited by 340 · see citing works
Uptake of human pharmaceuticals by plants grown under hydroponic conditions
Herklotz, P. A., Gurung, P., Heuvel, B. V., & Kinney, C. A. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2009.12.048 · Cited by 330 · see citing works
Müller, E., Schüssler, W., Horn, H., & Lemmer, H. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.02.070 · Cited by 294 · see citing works
Houba, V. J. G., Novozamsky, I., Lexmond, T. M., et al. (1990) · Communications in Soil Science and Plant Analysis · doi:10.1080/00103629009368380 · Cited by 272 · see citing works
Bondarczuk, K., Markowicz, A., & Piotrowska‐Seget, Z. (2015) · Environment International · doi:10.1016/j.envint.2015.11.011 · Cited by 261 · see citing works
Kästner, M., Nowak, K. M., Miltner, A., Trapp, S., & Schäffer, A. (2013) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2013.828270 · Cited by 258 · see citing works
Biological and chemical interactions of pesticides with soil organic matter
Bollag, J., Myers, C. J., & Minard, R. D. (1992) · The Science of The Total Environment · doi:10.1016/0048-9697(92)90146-j · Cited by 238 · see citing works
Biodegradation of pharmaceuticals by Rhodococcus rhodochrous and Aspergillus niger by co-metabolism
Gauthier, H., Yargeau, V., & Cooper, D. G. (2010) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2009.12.012 · Cited by 218 · see citing works
Monitoring of bacterial and parasitological contamination during various treatment of sludge
Gantzer, C., Gaspard, P., Gálvez, L. R. T., Huyard, A., Dumouthier, N., & Schwartzbrod, J. (2001) · Water Research · doi:10.1016/s0043-1354(01)00105-1 · Cited by 192 · see citing works
Cross-Coupling of Sulfonamide Antimicrobial Agents with Model Humic Constituents
Bialk, H. M., Simpson, A. J., & Pedersen, J. A. (2005) · Environmental Science & Technology · doi:10.1021/es0500916 · Cited by 190 · see citing works
Thorn, K. A., Pettigrew, P. J., Goldenberg, W. S., et al. (1996) · Environmental Science & Technology · doi:10.1021/es9509339 · Cited by 190 · see citing works
Fate of antibiotics from hospital and domestic sources in a sewage network
Dinh, Q. T., Moreau-Guigon, E., Labadie, P., Alliot, F., Teil, M., Blanchard, M., Eurin, J., & Chevreuil, M. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.09.118 · Cited by 185 · see citing works
Biodegradation of sulfamethoxazole by individual and mixed bacteria
Larcher, S., & Yargeau, V. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3257-8 · Cited by 173 · see citing works
Environmental Fate of Two Sulfonamide Antimicrobial Agents in Soil
Accinelli, C., Koskinen, W. C., Becker, J. M., et al. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf063709j · Cited by 170 · see citing works
Indicator of potential residual carbon in soils after exogenous organic matter application
Lashermes, G., Nicolardot, B., Parnaudeau, V., Thuriès, L., Chaussod, R., Guillotin, M. L., Linères, M., Mary, B., Metzger, L., Morvan, T., et al. (2009) · European Journal of Soil Science · doi:10.1111/j.1365-2389.2008.01110.x · Cited by 168 · see citing works
Sequestration of Manure-Applied Sulfadiazine Residues in Soils
Förster, M., Laabs, V., Lamshöft, M., et al. (2009) · Environmental Science & Technology · doi:10.1021/es8026538 · Cited by 163 · see citing works
The Regulation by Phenolic Compounds of Soil Organic Matter Dynamics under a Changing Environment
Min, K., Freeman, C., Kang, H., et al. (2015) · BioMed Research International · doi:10.1155/2015/825098 · Cited by 163 · see citing works
Zhang, Y., Hu, S., Zhang, H., Shen, G., Yuan, Z., & Zhang, W. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.083 · Cited by 152 · see citing works
Sorption of the Veterinary Antimicrobial Sulfathiazole to Organic Materials of Different Origin
Kahle, M., & Stamm, C. (2006) · Environmental Science & Technology · doi:10.1021/es061198b · Cited by 146 · see citing works
Biodegradation of sulfamethoxazole: current knowledge and perspectives
Larcher, S., & Yargeau, V. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4326-3 · Cited by 145 · see citing works
Kahle, M., & Stamm, C. (2007) · Chemosphere · doi:10.1016/j.chemosphere.2007.01.061 · Cited by 133 · see citing works
Liu, F., Wu, J., Ying, G., et al. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3831-0 · Cited by 116 · see citing works
Sorption and Desorption of Atrazine by Sludge‐Amended Soil: Dissolved Organic Matter Effects
Celis, R., Barriuso, E., & Houot, S. (1998) · Journal of Environmental Quality · doi:10.2134/jeq1998.00472425002700060011x · Cited by 113 · see citing works
Jimenez, J., Gonidec, E., Rivero, J. A. C., et al. (2013) · Water Research · doi:10.1016/j.watres.2013.10.048 · Cited by 106 · see citing works
Colloids as a sink for certain pharmaceuticals in the aquatic environment
Maskaoui, K., & Zhou, J. L. (2009) · Environmental Science and Pollution Research · doi:10.1007/s11356-009-0279-1 · Cited by 101 · see citing works
Occurrence of pharmaceuticals and hormones in sewage sludge
Nieto, A., Borrull, F., Pocurull, E., & Marcé, R. M. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.188 · Cited by 97 · see citing works
Islas-Espinoza, M., Reid, B. J., Wexler, M., & Bond, P. L. (2012) · Microbial Ecology · doi:10.1007/s00248-012-0010-5 · Cited by 97 · see citing works
Long-term monitoring of sulfonamide leaching from manure amended soil into groundwater
Spielmeyer, A., Höper, H., & Hamscher, G. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.03.020 · Cited by 96 · see citing works
Chemical and biological characterization of non-extractable sulfonamide residues in soil
Heise, J., Höltge, S., Schrader, S., et al. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.04.084 · Cited by 86 · see citing works
Jimenez, J., Aemig, Q., Doussiet, N., et al. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.07.037 · Cited by 82 · see citing works
NMR Investigation of Enzymatic Coupling of Sulfonamide Antimicrobials with Humic Substances
Bialk, H. M., & Pedersen, J. A. (2007) · Environmental Science & Technology · doi:10.1021/es070779d · Cited by 81 · see citing works
Liu, F., Ying, G., Yang, J., Zhou, L., Tao, R., Wang, L., Zhang, L., & Peng, P. (2010) · Environmental Chemistry · doi:10.1071/en09160 · Cited by 80 · see citing works
Le-Minh, N., Stuetz, R. M., & Khan, S. J. (2011) · Talanta · doi:10.1016/j.talanta.2011.12.053 · Cited by 78 · see citing works
Schmidt, B. C., Ebert, J., Lamshöft, M., et al. (2007) · Journal of Environmental Science and Health Part B · doi:10.1080/03601230701734824 · Cited by 68 · see citing works
Cleary, D., Bishop, A. H., Zhang, L., et al. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw159 · Cited by 68 · see citing works
Uptake of oxytetracycline, sulfamethoxazole and ketoconazole from fertilised soils by plants
Chițescu, C. L., Nicolau, A. I., & Stolker, A. A. M. (2012) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2012.725479 · Cited by 65 · see citing works
Laboratory Testing of Sulfamethoxazole and its Metabolite Acetyl‐Sulfamethoxazole in Soil
Höltge, S., & Kreuzig, R. (2007) · CLEAN - Soil Air Water · doi:10.1002/clen.200600019 · Cited by 59 · see citing works
Ferhi, S., Bourdat-Deschamps, M., Daudin, J., et al. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9725-3 · Cited by 47 · see citing works
Impact of manure-related DOM on sulfonamide transport in arable soils
Zhou, D., Thiele‐Bruhn, S., Arenz-Leufen, M., et al. (2016) · Journal of Contaminant Hydrology · doi:10.1016/j.jconhyd.2016.07.005 · Cited by 42 · see citing works
Dissipation pathways of organic pollutants during the composting of organic wastes
Lashermes, G., Barriuso, E., & Houot, S. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.12.004 · Cited by 40 · see citing works
Schwarz, J., Thiele‐Bruhn, S., Eckhardt, K., et al. (2012) · ISRN Soil Science · doi:10.5402/2012/159189 · Cited by 39 · see citing works
Ibekwe, A. M., Murinda, S. E., DebRoy, C., et al. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw006 · Cited by 37 · see citing works
Influence of organic amendment on fate of acetaminophen and sulfamethoxazole in soil
Li, J., Ye, Q., & Gan, J. J. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.08.019 · Cited by 29 · see citing works
Isoproturon movement and dissipation in undisturbed soil cores from a grassed buffer strip
Benoît, P., Barriuso, E., Vidon, P. G. F., et al. (2000) · Agronomie · doi:10.1051/agro:2000128 · Cited by 24 · see citing works
Mineralization of 4-aminobenzenesulfonate (4-ABS) by Agrobacterium sp. strain PNS-1
Singh, P. C., Birkeland, N.-K., Iyengar, L. R., et al. (2006) · Biodegradation · doi:10.1007/s10532-005-9017-7 · Cited by 22 · see citing works
Goulas, A., Bourdat-Deschamps, M., Nélieu, S., et al. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.06.192 · Cited by 22 · see citing works
Lachassagne, D., Soubrand, M., Casellas, M., et al. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4918-4 · Cited by 18 · see citing works
Fate of 14C-organic pollutant residues in composted sludge after application to soil
Haudin, C.-S., Zhang, Y., Dumeny, V., Lashermes, G., Bergheaud, V., Barriuso, E., & Houot, S. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.02.041 · Cited by 15 · see citing works
Self-citationGeng, C., Bergheaud, V., Garnier, P., et al. (2015) · Water Research · doi:10.1016/j.watres.2015.09.053 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Hof, M. A. J., de Haan, H., Stepanovic, S., Bakker, S. J. L., Hak, E., Hopfgartner, G., Klont, F., & Investigators, T. (2025) · Metabolites · doi:10.3390/metabo15070473 · Cited by 1 · see citing works
“Admittedly, acetylsulfamethoxazole’s reduced biological activity/toxicity compared to sulfamethoxazole may limit the relevance of measuring it [12,42,43].”
- Authors
- Geng, C., Bergheaud, V., Garnier, P., Zhu, Y.-G., & Haudin, C.-S.
- Affiliations
- Chinese Academy of Sciences (CN)
- AgroParisTech (FR)
- Corresponding author
- Haudin, Claire-Sophie
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 194
- Pages
- 828-836
- ISSN
- 0045-6535 (ISSN-L)
- OpenAlex
- W2771315838
- Cited by
- 18
- References
- 60
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 2
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Chemosphere (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-sa)
- Funders
- INRA
- French National Institute for Agricultural Research
- Natural Science Foundation of China (21210008)
- Smoking Research Foundation (10120K156001-YJ2015-1)
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Pollution › Pesticide and Herbicide Environmental Studies
- Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
- Keywords
- sludge treatment, antibiotic residues in soil, activated sludge, mineralization, soil amendment, biodegradation
- MeSH terms
- Agriculture, Anti-Infective Agents, Carbon Radioisotopes, Desiccation, Minerals, Oxides, Sewage, Soil, Soil Pollutants, Sulfamethoxazole, Calcium Compounds, Environmental Restoration and Remediation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
