CoChat
Sign Up
Cited by 745Antioxidant Activity and Oxidative StressRedox biology and oxidative stressFatty Acid Research and Health

The DOI matches its Crossref record; 116 of the 118 references it cites were found in a registry or an index.

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

Catalá, Angel·2009·Chemistry and Physics of Lipids
DOI 10.1016/j.chemphyslip.2008.09.004
Open this paper in CoChat — free account

Abstract

Polyunsaturated fatty acids (PUFAs) and their metabolites have a variety of physiological roles including: energy provision, membrane structure, cell signaling and regulation of gene expression. Lipids containing polyunsaturated fatty acids are susceptible to free radical-initiated oxidation and can participate in chain reactions that increase damage to biomolecules. Lipid peroxidation, which leads to lipid hydroperoxide formation often, occurs in response to oxidative stress. Hydroperoxides are usually reduced to their corresponding alcohols by glutathione peroxidases. However, these enzymes are decreased in certain diseases resulting in a temporary increase of lipid hydroperoxides that favors their degradation into several compounds, including hydroxy-alkenals. The best known of these are: 4-hydroxy-2-nonenal (4-HNE) and 4-hydroxy-2-hexenal (4-HHE), which derive from lipid peroxidation of n-6 and n-3 fatty acids, respectively. Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive molecules in physiological and/or pathological conditions. In addition this review is intended to provide an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling, from their intracellular production, to their action as intracellular messenger, up to their influence on transcription factors and gene expression.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.chemphyslip.2008.09.004

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 118 references

Research works printed but not linked: 1

  1. Spiteller, 2000, Oxidation of linoleic acid in low-density lipoprote: an important event in atherogenesis, Angew Chem. Int. Ed. Engl., 39, 585, 10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G · DOI

Cited by

Sorted by citations

Items 601–700 of 744

Related

See all

Metadata

Authors
Catalá, A.
Venue
Chemistry and Physics of Lipids
Publisher
Elsevier BV
Published
2009-01
Volume
157
Issue
1
Pages
1-11
ISSN
0009-3084 (ISSN-L)
DOI
10.1016/j.chemphyslip.2008.09.004
OpenAlex
W2076519801
Cited by
745
References
118
Citations by year
2026: 19 · 2025: 26 · 2024: 36 · 2023: 40 · 2022: 34 · 2021: 50 · 2020: 44 · 2019: 53 · 2018: 39 · 2017: 35 · 2016: 54 · 2015: 55 · 2014: 36 · 2013: 49 · 2012: 47
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Chemistry and Physics of Lipids (publishedVersion)
  • PubMed (publishedVersion)
Funders
Consejo Nacional de Investigaciones Científicas y Técnicas
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
lipid peroxidation, membrane phospholipids, 4-hydroxynonenal, 4-hydroxy-2-hexenal, oxidized phospholipids, polyunsaturated fatty acids, oxidative stress, glutathione peroxidase, lipid hydroperoxides, protein aldehyde adducts, signal transduction, intracellular messengers, transcription factors, gene expression regulation, omega-6 fatty acids, omega-3 fatty acids
MeSH terms
Aldehydes, Animals, Cells, Fatty Acids, Unsaturated, Humans, Oxidation-Reduction, Phospholipids, Lipid Peroxidation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review