The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics
Open accessAbstract
Summary Intracellular pathogens have devised mechanisms to exploit their host cells to ensure their survival and replication. The malaria parasite Plasmodium falciparum relies on an exchange of metabolites with the host for proliferation. We describe the first mass spectrometry-based metabolomic analysis of the parasite throughout its 48-hour intraerythrocytic developmental cycle. Our results reveal a general modulation of metabolite levels by the parasite, with numerous metabolites varying in phase with the developmental cycle. Others differed from uninfected cells irrespective of the developmental stage. Among these was extracellular arginine, which was specifically converted to ornithine by the parasite. To identify the biochemical basis for this effect, we disrupted the plasmodium arginase gene in the rodent malaria model P. berghei. These parasites were viable but did not convert arginine to ornithine. Our results suggest that systemic arginine depletion by the parasite may be a factor in human malarial hypoargininemia associated with cerebral malaria pathogenesis.
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Cites
Genome sequence of the human malaria parasite Plasmodium falciparum
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Metabolic maps and functions of the Plasmodium falciparum apicoplast
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Red blood cells express a functional endothelial nitric oxide synthase
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Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
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Cited by
Effect of Antibiotic Treatment on the Intestinal Metabolome
Antunes, L. C. M., Han, J., Ferreira, R. B. R., Lolić, P., Borchers, C. H., & Finlay, B. B. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01664-10 · Cited by 271
Metadata
- Authors
- Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., & Llinás, M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 5
- Issue
- 2
- Pages
- 191-199
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1977041255
- Cited by
- 289
- References
- 40
- FWCI
- 22.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., & Llinás, M. (2009). Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2009.01.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
