The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria
Open accessAbstract
The functional spectrum of a secretion system is defined by its substrates. Here we analyzed the secretomes of Pseudomonas aeruginosa mutants altered in regulation of the Hcp Secretion Island-I-encoded type VI secretion system (H1-T6SS). We identified three substrates of this system, proteins Tse1-3 (type six exported 1-3), which are coregulated with the secretory apparatus and secreted under tight posttranslational control. The Tse2 protein was found to be the toxin component of a toxin-immunity system and to arrest the growth of prokaryotic and eukaryotic cells when expressed intracellularly. In contrast, secreted Tse2 had no effect on eukaryotic cells; however, it provided a major growth advantage for P. aeruginosa strains, relative to those lacking immunity, in a manner dependent on cell contact and the H1-T6SS. This demonstration that the T6SS targets a toxin to bacteria helps reconcile the structural and evolutionary relationship between the T6SS and the bacteriophage tail and spike.
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Cites
Type VII secretion — mycobacteria show the way
Abdallah, A. M., Gey van Pittius, N. C., DiGiuseppe Champion, P. A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., & Bitter, W. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1773 · Cited by 763
Cited by
Type VI secretion delivers bacteriolytic effectors to target cells
Russell, A. B., Hood, R. D., Bui, N. K., LeRoux, M., Vollmer, W., & Mougous, J. D. (2011) · Nature · doi:10.1038/nature10244 · Cited by 710
Self-citationMicrobiota-mediated colonization resistance: mechanisms and regulation
Caballero-Flores, G., Pickard, J. M., & Núñez, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00833-7 · Cited by 474
Rhs proteins from diverse bacteria mediate intercellular competition
Koskiniemi, S., Lamoureux, J. G., Nikolakakis, K. C., t'Kint de Roodenbeke, C., Kaplan, M. D., Low, D. A., & Hayes, C. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300627110 · Cited by 414
Bacterial Contact-Dependent Delivery Systems
Hayes, C. S., Aoki, S. K., & Low, D. A. (2010) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091449 · Cited by 257
Si, M., Zhao, C., Burkinshaw, B., Zhang, B., Wei, D., Wang, Y., Dong, T. G., & Shen, X. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614902114 · Cited by 245
Metadata
- Authors
- Hood, R. D., Singh, P., Hsu, F., Güvener, T., Carl, M. A., Trinidad, R. R. S., Silverman, J. M., Ohlson, B. B., Hicks, K. G., Plemel, R. L., Li, M., Schwarz, S., Wang, W. Y., Merz, A. J., Goodlett, D. R., & Mougous, J. D.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 7
- Issue
- 1
- Pages
- 25-37
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2136910774
- Cited by
- 932
- References
- 1
- FWCI
- 30.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hood, R. D., Singh, P., Hsu, F., Güvener, T., Carl, M. A., Trinidad, R. R. S., Silverman, J. M., Ohlson, B. B., Hicks, K. G., Plemel, R. L., Li, M., Schwarz, S., Wang, W. Y., Merz, A. J., Goodlett, D. R., & Mougous, J. D. (2010). A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2009.12.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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