The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Type VI secretion delivers bacteriolytic effectors to target cells
Open accessAbstract
Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane. Here we show that the type VI secretion system of Pseudomonas aeruginosa breaches this barrier to deliver two effector proteins, Tse1 and Tse3, to the periplasm of recipient cells. In this compartment, the effectors hydrolyse peptidoglycan, thereby providing a fitness advantage for P. aeruginosa cells in competition with other bacteria. To protect itself from lysis by Tse1 and Tse3, P. aeruginosa uses specific periplasmically localized immunity proteins. The requirement for these immunity proteins depends on intercellular self-intoxication through an active type VI secretion system, indicating a mechanism for export whereby effectors do not access donor cell periplasm in transit.
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Cites
The Pfam Protein Families Database
Bateman, A. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,000
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Bacterial biofilms: from the Natural environment to infectious diseases
Hall-Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,143
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Stover, C. K., Pham, X. Q., Erwin, A. L., Mizoguchi, S. D., Warrener, P., Hickey, M. J., Brinkman, F. S. L., Hufnagle, W. O., Kowalik, D. J., Lagrou, M., et al. (2000) · Nature · doi:10.1038/35023079 · Cited by 4,573
Protein structure prediction on the Web: a case study using the Phyre server
Kelley, L. A., & Sternberg, M. J. E. (2009) · Nature Protocols · doi:10.1038/nprot.2009.2 · Cited by 4,175
The Pfam protein families database
Finn, R. D., Mistry, J., Tate, J., Coggill, P., Heger, A., Pollington, J. E., Gavin, O. L., Gunasekaran, P., Ceric, G., Forslund, K., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp985 · Cited by 2,694
Bacterial competition: surviving and thriving in the microbial jungle
Hibbing, M. E., Fuqua, C., Parsek, M. R., & Peterson, S. B. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2259 · Cited by 2,689
Nelson, K. E., Weinel, C., Paulsen, I. T., Dodson, R. J., Hilbert, H., Martins dos Santos, V. A. P., Fouts, D. E., Gill, S. R., Pop, M., Holmes, M., et al. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00366.x · Cited by 1,340
Bacteriocins: Evolution, Ecology, and Application
Riley, M. A., & Wertz, J. E. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.161024 · Cited by 1,236
A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus
Mougous, J. D., Cuff, M. E., Raunser, S., Shen, A., Zhou, M., Gifford, C. A., Goodman, A. L., Joachimiak, G., Ordoñez, C. L., Lory, S., et al. (2006) · Science · doi:10.1126/science.1128393 · Cited by 1,103
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Cited by
Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
Kim, S., Covington, A., & Pamer, E. G. (2017) · Immunological Reviews · doi:10.1111/imr.12563 · Cited by 741
Si, M., Zhao, C., Burkinshaw, B., Zhang, B., Wei, D., Wang, Y., Dong, T. G., & Shen, X. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614902114 · Cited by 245
Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity
Wang, T., Si, M., Song, Y., Zhu, W., Gao, F., Wang, Y., Zhang, L., Zhang, W., Wei, G., Luo, Z.-Q., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005020 · Cited by 210
ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis
Wang, T., Chen, K., Gao, F., Kang, Y., Chaudhry, M. T., Wang, Z., Wang, Y., & Shen, X. (2017) · Journal of Microbiology · doi:10.1007/s12275-017-6540-2 · Cited by 29
Metadata
- Authors
- Russell, A. B., Hood, R. D., Bui, N. K., LeRoux, M., Vollmer, W., & Mougous, J. D.
- Venue
- Nature
- Published
- 2011-07
- Volume
- 475
- Issue
- 7356
- Pages
- 343-347
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2125832470
- Cited by
- 710
- References
- 44
- FWCI
- 34.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Russell, A. B., Hood, R. D., Bui, N. K., LeRoux, M., Vollmer, W., & Mougous, J. D. (2011). Type VI secretion delivers bacteriolytic effectors to target cells. Nature. https://doi.org/10.1038/nature10244
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