The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Statins Enhance Formation of Phagocyte Extracellular Traps
Open accessAbstract
SUMMARY Statins are inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis. Several recent clinico-epidemiologic studies have revealed that patients receiving statin therapy have reduced mortality associated with severe bacterial infection. Here we study pharmacological effect of statins on the innate immune capacity of phagocytic cells, focusing on the leading human bacterial pathogen Staphylococcus aureus. These studies revealed a beneficial effect of statins on S. aureus clearance using in vivo, ex vivo and in vitro models of phagocyte function, although paradoxically both phagocytosis and oxidative burst were inhibited. Probing instead for an extracellular mechanism of killing, we found statins boosted the production of anti-bacterial DNA-based extracellular traps (ETs) by human and murine neutrophils and also monocyte/macrophages. The effect of statins to induce phagocyte ETs was linked to sterol pathway inhibition by RNA interference and specific pharmacologic inhibitors. We conclude that a drug therapy taken chronically by tens of millions of individuals alters the functional behavior of phagocytic cells, which could have ramifications for susceptibility and response to bacterial infections in these patients.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Netting neutrophils in autoimmune small-vessel vasculitis
Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W., Gross, W. L., Werb, Z., Gröne, H.-J., Brinkmann, V., & Jenne, D. E. (2009) · Nature Medicine · doi:10.1038/nm.1959 · Cited by 1,648
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Self-citationImpairment of neutrophil extracellular trap degradation is associated with lupus nephritis
Hakkim, A., Fürnrohr, B. G., Amann, K., Laube, B., Abed, U. A., Brinkmann, V., Herrmann, M., Voll, R. E., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909927107 · Cited by 1,469
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00659.x · Cited by 1,012
Beneficial suicide: why neutrophils die to make NETs
Brinkmann, V., & Zychlinsky, A. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1710 · Cited by 937
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Self-citationAn Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps
Beiter, K., Wartha, F., Albiger, B., Normark, S., Zychlinsky, A., & Henriques-Normark, B. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.056 · Cited by 587
Cited by
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Yipp, B. G., & Kubes, P. (2013) · Blood · doi:10.1182/blood-2013-04-457671 · Cited by 989
Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis
Fuchs, T. A., Brill, A., & Wagner, D. D. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.242859 · Cited by 586
NETosis: Molecular Mechanisms, Role in Physiology and Pathology
Vorobjeva, N. V., & Chernyak, B. V. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920100065 · Cited by 559
Neutrophil extracellular traps — the dark side of neutrophils
Sørensen, O. E., & Borregaard, N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84538 · Cited by 528
Metadata
- Authors
- Chow, O. A., von Köckritz-Blickwede, M., Bright, A. T., Hensler, M. E., Zinkernagel, A. S., Cogen, A. L., Gallo, R. L., Monestier, M., Wang, Y., Glass, C. K., & Nizet, V.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 8
- Issue
- 5
- Pages
- 445-454
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1970156474
- Cited by
- 431
- References
- 43
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chow, O. A., von Köckritz-Blickwede, M., Bright, A. T., Hensler, M. E., Zinkernagel, A. S., Cogen, A. L., Gallo, R. L., Monestier, M., Wang, Y., Glass, C. K., & Nizet, V. (2010). Statins Enhance Formation of Phagocyte Extracellular Traps. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2010.10.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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