The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
Open accessAbstract
Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin. These neutrophil extracellular traps (NETs) degrade virulence factors and kill Gram positive and negative bacteria. Here we show for the first time that Candida albicans, a eukaryotic pathogen, induces NET-formation and is susceptible to NET-mediated killing. C. albicans is the predominant aetiologic agent of fungal infections in humans, particularly in immunocompromised hosts. One major virulence trait of C. albicans is its ability to reversibly switch from singular budding cells to filamentous hyphae. We demonstrate that NETs kill both yeast-form and hyphal cells, and that granule components mediate fungal killing. Taken together our data indicate that neutrophils trap and kill ascomycetous yeasts by forming NETs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Self-citationJaneway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
Interaction of Candida albicans with Human Leukocytes and Serum
Lehrer, R. I., & Cline, M. J. (1969) · Journal of Bacteriology · doi:10.1128/jb.98.3.996-1004.1969 · Cited by 531
Interactions of fungi with phagocytes
Mansour, M. K., & Levitz, S. M. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00342-9 · Cited by 132
Molecular organization of the cell wall of Candida albicans
Klis, F. M., De Groot, P., & Hellingwerf, K. (2001) · Medical Mycology · doi:10.1080/744118876 · Cited by 111
Research works printed but not linked: 28
- Borregaard N., 1997, Blood, 89, 3503, 10.1182/blood.V89.10.3503 · DOI · Paper page
- Christin L., 1997, J Infect Dis, 176, 1567, 10.1086/514156 · DOI
- Cockayne A., 1984, J Gen Microbiol, 130, 465
- 10.1016/j.fgb.2005.04.002 · DOI · Paper page
- Diamond R.D., 1978, J Clin Invest, 61, 349, 10.1172/JCI108945 · DOI · Paper page
- 10.1128/IAI.73.2.865-871.2005 · DOI
- Edwards J.E., 1987, Blood, 69, 1450, 10.1182/blood.V69.5.1450.1450 · DOI
- 10.1016/S1369-5274(02)00338-7 · DOI · Paper page
- Hampton M.B., 1998, Blood, 92, 3007, 10.1182/blood.V92.9.3007 · DOI · Paper page
- Hiemstra P.S., 1993, Infect Immun, 61, 3038, 10.1128/IAI.61.7.3038-3046.1993 · DOI
- Hii C.S., 1999, Infect Immun, 67, 1297, 10.1128/IAI.67.3.1297-1302.1999 · DOI
- 10.1084/jem.108.6.925 · DOI · Paper page
- Kim H.S., 2002, J Immunol, 168, 2356, 10.4049/jimmunol.168.5.2356 · DOI
- Lehrer R.I., 1969, J Clin Invest, 48, 1478, 10.1172/JCI106114 · DOI · Paper page
- 10.1128/AAC.44.12.3257-3263.2000 · DOI
- 10.1111/j.1462-5822.2004.00439.x · DOI · Paper page
- 10.1086/340511 · DOI · Paper page
- 10.1128/IAI.73.2.770-777.2005 · DOI
- 10.1089/152308602753625889 · doi:10.1089/152308602753625889
- 10.1038/nri1255 · DOI · Paper page
- 10.1146/annurev.immunol.23.021704.115653 · DOI · Paper page
- Takei H., 1996, J Leukoc Biol, 59, 229, 10.1002/jlb.59.2.229 · DOI · Paper page
- Thompson H.L., 1992, Clin Exp Immunol, 87, 316, 10.1111/j.1365-2249.1992.tb02994.x · DOI
- Weiss J., 1978, J Biol Chem, 253, 2664, 10.1016/S0021-9258(17)40872-6 · DOI · Paper page
- Weiss J., 1985, J Clin Invest, 76, 206, 10.1172/JCI111947 · DOI
- 10.1016/j.mib.2004.06.005 · DOI · Paper page
- Wright C.D., 1985, Infect Immun, 47, 363, 10.1128/IAI.47.2.363-365.1985 · doi:10.1128/iai.47.2.363-365.1985
- Wysong D.R., 1989, Infect Immun, 57, 1499, 10.1128/IAI.57.5.1499-1505.1989 · DOI
Cited by
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.105 · Cited by 3,397
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Self-citationNeutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103
Self-citationSurface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Neutrophil extracellular traps: Is immunity the second function of chromatin?
Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021
Self-citation
Metadata
- Authors
- Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2006-04
- Volume
- 8
- Issue
- 4
- Pages
- 668-676
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2016385216
- Cited by
- 1,012
- References
- 8
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3440 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. https://app.cochat.ai/papers/10.1111/j.1462-5822.2005.00659.x
- The paper
- Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A. (2006). Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. Cellular Microbiology. https://doi.org/10.1111/j.1462-5822.2005.00659.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
