NETosis: Molecular Mechanisms, Role in Physiology and Pathology

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

COVID-19: consider cytokine storm syndromes and immunosuppression

Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30628-0 · Cited by 9,664 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Novel cell death program leads to neutrophil extracellular traps

Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197 · see citing works

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309 · see citing works

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

Kroemer, G., Dallaporta, B., & Resche-Rigon, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.619 · Cited by 1,971 · see citing works

Neutrophil extracellular traps in COVID-19

Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J. A., Blair, C., Weber, A. G., Barnes, B. J., Egeblad, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138999 · Cited by 1,602 · see citing works

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570 · see citing works

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Rogers, C., Fernandes-Alnemri, T., Mayes, L., Alnemri, D., Cingolani, G., & Alnemri, E. S. (2017) · Nature Communications · doi:10.1038/ncomms14128 · Cited by 1,510 · see citing works

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495 · see citing works

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200652 · Cited by 1,486 · see citing works

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

Khandpur, R., Carmona‐Rivera, C., Vivekanandan‐Giri, A., Gizinski, A. M., Yalavarthi, S., Knight, J. S., Friday, S. C., Li, S., Patel, R. M., Subramanian, V., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005580 · Cited by 1,342 · see citing works

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

Yipp, B. G., Petri, B., Salina, D., Jenne, C. N., Scott, B. N. V., Zbytnuik, L. D., Pittman, K., Asaduzzaman, M., Wu, K., Meijndert, H. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2847 · Cited by 1,169 · see citing works

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0669-6 · Cited by 1,145 · see citing works

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

Scorrano, L., Ashiya, M., Buttle, K., Weiler, S., Oakes, S. A., Mannella, C. A., & Korsmeyer, S. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00116-2 · Cited by 1,072 · see citing works

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

Yousefi, S., Mihalache, C., Kozlowski, E., Schmid, I., & Simon, H. U. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.96 · Cited by 1,036 · see citing works

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

Schauer, C., Janko, C., Munoz, L. E., Zhao, Y., Kienhöfer, D., Frey, B., Lell, M., Manger, B., Rech, J., Naschberger, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3547 · Cited by 998 · see citing works

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Yousefi, S., Gold, J. A., Andina, N., Lee, J. J., Kelly, A. M., Kozlowski, E., Schmid, I., Straumann, A., Reichenbach, J., Gleich, G. J., et al. (2008) · Nature Medicine · doi:10.1038/nm.1855 · Cited by 967 · see citing works

Thrombosis: tangled up in NETs

Martinod, K., & Wagner, D. D. (2013) · Blood · doi:10.1182/blood-2013-10-463646 · Cited by 875 · see citing works

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

Griffiths, E. J., & Halestrap, A. P. (1995) · Biochemical Journal · doi:10.1042/bj3070093 · Cited by 838 · see citing works

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Rogers, C., Erkes, D. A., Nardone, A., Aplin, A. E., Fernandes‐Alnemri, T., & Alnemri, E. S. (2019) · Nature Communications · doi:10.1038/s41467-019-09397-2 · Cited by 834 · see citing works

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Remijsen, Q., Berghe, T. V., Wirawan, E., Asselbergh, B., Parthoens, E., De Rycke, R., Noppen, S., Delforge, M., Willems, J., & Vandenabeele, P. (2011) · Cell Research · doi:10.1038/cr.2010.150 · Cited by 818 · see citing works

Diverse stimuli engage different neutrophil extracellular trap pathways

Kenny, E. F., Herzig, A., Krüger, R., Muth, A., Mondal, S., Thompson, P. R., Brinkmann, V., von Bernuth, H., & Zychlinsky, A. (2017) · eLife · doi:10.7554/elife.24437 · Cited by 804 · see citing works

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

Hakkim, A., Fuchs, T. A., Martinez, N. E., Hess, S., Prinz, H., Zychlinsky, A., & Waldmann, H. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.496 · Cited by 793 · see citing works

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

Metzler, K. D., Fuchs, T. A., Nauseef, W. M., Reumaux, D., Roesler, J., Schulze, I., Wahn, V., Papayannopoulos, V., & Zychlinsky, A. (2010) · Blood · doi:10.1182/blood-2010-06-290171 · Cited by 775 · see citing works

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

Sollberger, G., Choidas, A., Burn, G. L., Habenberger, P., Lucrezia, R. D., Kordes, S., Menninger, S., Eickhoff, J., Nußbaumer, P., Klebl, B., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6689 · Cited by 761 · see citing works

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

Metzler, K. D., Goosmann, C., Lubojemska, A., Zychlinsky, A., & Papayannopoulos, V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.044 · Cited by 741 · see citing works

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

Saitoh, T., Komano, J. A., Saitoh, Y., Misawa, T., Takahama, M., Kozaki, T., Uehata, T., Iwasaki, H., Omori, H., Yamaoka, S., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.05.015 · Cited by 731 · see citing works

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

Douda, D. N., Khan, M. A., Grasemann, H., & Palaniyar, N. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414055112 · Cited by 696 · see citing works

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Chen, K. W., Monteleone, M. M., Boucher, D., Sollberger, G., Ramnath, D., Condon, N. D., von Pein, J. B., Brož, P., Sweet, M. J., & Schroder, K. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6676 · Cited by 640 · see citing works

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

Bernardi, P., Rasola, A., Forte, M. A., & Lippe, G. (2015) · Physiological Reviews · doi:10.1152/physrev.00001.2015 · Cited by 586 · see citing works

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

von Köckritz‐Blickwede, M., Goldmann, O., Thulin, P., Heinemann, K., Norrby‐Teglund, A., Rohde, M., & Medina, E. (2008) · Blood · doi:10.1182/blood-2007-07-104018 · Cited by 553 · see citing works

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

Martinod, K., Demers, M., Fuchs, T. A., Wong, S. L., Brill, A. G., Gallant, M., Hu, J., Wang, Y., & Wagner, D. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301059110 · Cited by 532 · see citing works

The role of neutrophils and NETosis in autoimmune and renal diseases

Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 433 · see citing works

Statins Enhance Formation of Phagocyte Extracellular Traps

Chow, O. A., von Köckritz‐Blickwede, M., Bright, A. T., Hensler, M. E., Zinkernagel, A. S., Cogen, A. L., Gallo, R. L., Monestier, M., Wang, Y., Glass, C. K., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.10.005 · Cited by 431 · see citing works

Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis

Takei, H., Araki, A., Watanabe, H. K., Ichinose, A., & Sendo, F. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.2.229 · Cited by 429 · see citing works

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Kambara, H., Liu, F., Zhang, X., Liu, P., Bajrami, B., Teng, Y., Zhao, L., Zhou, S., Yu, H., Zhou, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.067 · Cited by 418 · see citing works

Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology

Ravindran, M., Khan, M. A., & Palaniyar, N. (2019) · Biomolecules · doi:10.3390/biom9080365 · Cited by 328 · see citing works

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

Toussaint, M., Jackson, D. J., Swieboda, D. P., Guedán, A., Tsourouktsoglou, T.-D., Ching, Y. M., Radermecker, C., Makrinioti, H., Aniscenko, J., Bartlett, N. W., et al. (2017) · Nature Medicine · doi:10.1038/nm.4332 · Cited by 323 · see citing works

Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death

Steinberg, B. E., & Grinstein, S. (2007) · Science s STKE · doi:10.1126/stke.3792007pe11 · Cited by 319 · see citing works

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis

Carmona‐Rivera, C., Carlucci, P. M., Moore, E., Lingampalli, N., Uchtenhagen, H., James, E. A., Liu, Y., Bicker, K. L., Wähämaa, H., Hoffmann, V. J., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aag3358 · Cited by 311 · see citing works

Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses

Fousert, E., Toes, R. E. M., & Desai, J. (2020) · Cells · doi:10.3390/cells9040915 · Cited by 286 · see citing works

Regulation of Extracellular Chromatin Release from Neutrophils

Neeli, I., Dwivedi, N., Khan, S. N., & Radic, M. Z. (2009) · Journal of Innate Immunity · doi:10.1159/000206974 · Cited by 279 · see citing works

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps

Amulic, B., Knackstedt, S. L., Abed, U. A., Deigendesch, N., Harbort, C. J., Caffrey, B. E., Brinkmann, V., Heppner, F. L., Hinds, P. W., & Zychlinsky, A. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.10.013 · Cited by 269 · see citing works

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

Schreiber, A., Rousselle, A., Becker, J. U., von Mäßenhausen, A., Linkermann, A., & Kettritz, R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708247114 · Cited by 257 · see citing works

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

Papayannopoulos, V., Staab, D., & Zychlinsky, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028526 · Cited by 252 · see citing works

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

Kröller‐Schön, S., Steven, S., Kossmann, S., Scholz, A., Daub, S., Oelze, M. W., Xia, N., Hausding, M., Mikhed, Y., Zinßius, E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4953 · Cited by 246 · see citing works

Lysosomal membrane permeabilization in cell death: Concepts and challenges

Repnik, U., Česen, M. H., & Turk, B. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.06.006 · Cited by 235 · see citing works

PMA and crystal‐induced neutrophil extracellular trap formation involves RIPK1‐RIPK3‐MLKL signaling

Desai, J., Kumar, S. V. R., Mulay, S. R., Konrad, L., Romoli, S., Schauer, C., i, M. H., Bilyy, R. O., Müller, S., Popper, B., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545605 · Cited by 233 · see citing works

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Leppkes, M., Maueröder, C., Hirth, S., Nowecki, S., Günther, C., Billmeier, U., Paulus, S., Biermann, M. H. C., Munoz, L. E., Hoffmann, M. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10973 · Cited by 227 · see citing works

Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

Tsourouktsoglou, T.-D., Warnatsch, A., Ιωάννου, Μ., Hoving, D., Wang, Q., & Papayannopoulos, V. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107602 · Cited by 227 · see citing works

Platelet-Neutrophil Interplay: Insights Into Neutrophil Extracellular Trap (NET)-Driven Coagulation in Infection

Zucoloto, A. Z., & Jenne, C. N. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00085 · Cited by 208 · see citing works

Targeting Tumor Vasculature With an Oncolytic Virus

Breitbach, C. J., Silva, N. S. D., Falls, T. J., Aladl, U. E., Evgin, L., Paterson, J. M., Sun, Y., Roy, D. G., Rintoul, J. L., Daneshmand, M., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.26 · Cited by 204 · see citing works

Neutrophil Extracellular Traps Initiate Gallstone Formation

Muñoz, L. E., Boeltz, S., Bilyy, R., Schauer, C., Mahajan, A., Widulin, N., Grüneboom, A., Herrmann, I., Boada, E., Rauh, M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.07.002 · Cited by 192 · see citing works

Neutrophil extracellular traps in breast cancer and beyond: current perspectives on NET stimuli, thrombosis and metastasis, and clinical utility for diagnosis and treatment

Snoderly, H. T., Boone, B. A., & Bennewitz, M. F. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1237-6 · Cited by 192 · see citing works

Neutrophil extracellular traps and their role in the development of chronic inflammation and autoimmunity

Pinegin, B. V., Vorobjeva, N. V., & Pinegin, V. B. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.03.002 · Cited by 178 · see citing works

The pathway of neutrophil extracellular traps towards atherosclerosis and thrombosis

Moschonas, I. C., & Tselepis, A. D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.06.919 · Cited by 165 · see citing works

The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease

Twaddell, S. H., Baines, K. J., Grainge, C., & Gibson, P. G. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.06.012 · Cited by 163 · see citing works

NADPH Oxidase–Independent Formation of Extracellular DNA Traps by Basophils

Morshed, M., Hlushchuk, R., Simon, D., Walls, A. F., Obata-Ninomiya, K., Karasuyama, H., Djonov, V., Eggel, A., Kaufmann, T., Simon, H.-U., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303418 · Cited by 161 · see citing works

Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation

Yost, C. C., Schwertz, H., Cody, M. J., Wallace, J. A., Campbell, R. A., Vieira‐de‐Abreu, A., de Araujo, C. V., Schubert, S., Harris, E. S., Rowley, J. W., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83873 · Cited by 151 · see citing works

Human blood monocytes are able to form extracellular traps

Granger, V., Faille, D., Marani, V., Noël, B., Gallais, Y., Szely, N., Flament, H., Pallardy, M. J., Chollet‐Martin, S., & de Chaisemartin, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ma0916-411r · Cited by 150 · see citing works

Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction

Novotny, J., Oberdieck, P., Titova, A., Pelisek, J., Chandraratne, S., Nicol, P., Hapfelmeier, A., Joner, M., Mäegdefessel, L., Poppert, H., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009532 · Cited by 142 · see citing works

Mitochondrial reactive oxygen species are involved in chemoattractant-induced oxidative burst and degranulation of human neutrophils in vitro

Vorobjeva, N., Prikhodko, A., Galkin, I., Pletjushkina, O., Zinovkin, R., Sud’ina, G., Chernyak, B., & Pinegin, B. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.03.003 · Cited by 138 · see citing works

Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils

Vorobjeva, N., Galkin, I., Pletjushkina, O., Golyshev, S., Zinovkin, R., Prikhodko, A., Pinegin, V., Kondratenko, I., Pinegin, B., & Chernyak, B. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165664 · Cited by 136 · see citing works

Neutrophil Extracellular Traps: Mechanisms of formation and role in health and disease

Vorobjeva, N. V., & Pinegin, B. V. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914120025 · Cited by 132 · see citing works

Ocular Surface Extracellular DNA and Nuclease Activity Imbalance: A New Paradigm for Inflammation in Dry Eye Disease

Sonawane, S. S., Khanolkar, V., Namavari, A., Chaudhary, S., Gandhi, S., Tibrewal, S., Jassim, S. H., Shaheen, B., Hallak, J., Horner, J. H., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10430 · Cited by 128 · see citing works

Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C

Ingelsson, B., Appelgren, D., Strid, T., Söderberg, A., Bergh, A.-C., Loitto, V. M., Lotfi, K., Segelmark, M., Spyrou, G., & Rosén, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711950115 · Cited by 127 · see citing works

Social amoebae trap and kill bacteria by casting DNA nets

Zhang, X., Zhuchenko, O., Kuspa, A., & Soldati, T. (2016) · Nature Communications · doi:10.1038/ncomms10938 · Cited by 124 · see citing works

Root Border Cells and Their Role in Plant Defense

Hawes, M. C., Allen, C., Turgeon, B. G., Curlango‐Rivera, G., Tran, T. M., Huskey, D. A., & Xiong, Z. (2016) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080615-100140 · Cited by 120 · see citing works

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Healy, L. D., Puy, C., Fernández, J. A., Mitrugno, A., Keshari, R. S., Taku, N. A., Chu, T. T., Xu, X., Gruber, A., Lupu, F., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.768309 · Cited by 117 · see citing works

Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone

de Souza, C. N., Breda, L. C. D., Khan, M. A., de Almeida, S. R., Câmara, N. O. S., Sweezey, N., & Palaniyar, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01849 · Cited by 116 · see citing works

Markers of neutrophil extracellular traps predict adverse outcome in community-acquired pneumonia: secondary analysis of a randomised controlled trial

Ebrahimi, F., Giaglis, S., Hahn, S., Blum, C. A., Baumgartner, C., Kutz, A., van Breda, S. V., Müeller, B., Schüetz, P., Christ‐Crain, M., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01389-2017 · Cited by 113 · see citing works

NETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma

Uddin, M., Watz, H., Malmgren, A., & Pedersen, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00047 · Cited by 113 · see citing works

Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology

Hahn, S., Giaglis, S., Chowdhury, C. S., Hösli, I., & Hasler, P. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0380-x · Cited by 111 · see citing works

In vivo evidence for extracellular DNA trap formation

Yousefi, S., Simon, D., Stojkov, D., Васильевна, К. А., Karaulov, A. V., & Simon, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2497-x · Cited by 111 · see citing works

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

D’Cruz, A. A., Speir, M., Bliss‐Moreau, M., Dietrich, S., Wang, S., Chen, A. A., Gavillet, M., Al‐Obeidi, A., Lawlor, K. E., Vince, J. E., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aao1716 · Cited by 109 · see citing works

Mechanisms for redox-regulation of protein kinase C

Steinberg, S. F. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00128 · Cited by 105 · see citing works

The role of mitochondrial ROS in antibacterial immunity

Pinegin, B. V., Vorobjeva, N. V., Pashenkov, M. V., & Chernyak, B. V. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26117 · Cited by 105 · see citing works

Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study

Tagami, T., Tosa, R., Omura, M., Fukushima, H., Kaneko, T., Endo, T., Rinka, H., Murai, A., Yamaguchi, J., Yoshikawa, K., et al. (2014) · Journal of Intensive Care · doi:10.1186/s40560-014-0067-y · Cited by 104 · see citing works

Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies

An, S., Raju, I., Surenkhuu, B., Kwon, J.-E., Gulati, S., Karaman, M., Pradeep, A., Sinha, S., Mun, C., & Jain, S. K. (2019) · The Ocular Surface · doi:10.1016/j.jtos.2019.03.010 · Cited by 102 · see citing works

Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP

Shishikura, K., Horiuchi, T., Sakata, N., Trinh, D., Shirakawa, R., Kimura, T., Asada, Y., & Horiuchi, H. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13373 · Cited by 101 · see citing works

Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome

Brzheskiy, V. V., Efimova, E. L., Vorontsova, T. N., Алексеев, В. Н., Гусаревич, О. Г., Shaidurova, K. N., Ryabtseva, A. A., Andryukhina, O. M., Kamenskikh, T. G., Сумарокова, Е. С., et al. (2015) · Advances in Therapy · doi:10.1007/s12325-015-0273-6 · Cited by 101 · see citing works

Formation of Neutrophil Extracellular Traps under Low Oxygen Level

Branitzki‐Heinemann, K., Möllerherm, H., Völlger, L., Husein, D. M., de Buhr, N., Blodkamp, S., Reuner, F., Brogden, G., Naim, H. Y., & von Köckritz‐Blickwede, M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00518 · Cited by 99 · see citing works

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

Nazarewicz, R. R., Dikalova, A., Bikineyeva, A. T., & Dikalov, S. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00063.2013 · Cited by 98 · see citing works

Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps

Behnen, M., Möller, S., Brozek, A., Klinger, M. H. F., & Laskay, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00184 · Cited by 97 · see citing works

Biological function of eosinophil extracellular traps in patients with severe eosinophilic asthma

Choi, Y., Pham, D. L., Lee, D., Lee, S. H., Kim, S., & Park, H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0136-8 · Cited by 95 · see citing works

The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host

Lodge, K. M., Cowburn, A. S., Li, W., & Condliffe, A. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041183 · Cited by 95 · see citing works

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

Fortner, K. A., Blanco, L. P., Buskiewicz, I. A., Huang, N., Gibson, P. C., Cook, D. L., Pedersen, H. L., Yuen, P. S. T., Murphy, M. P., Perl, A., et al. (2020) · Lupus Science & Medicine · doi:10.1136/lupus-2020-000387 · Cited by 94 · see citing works

Neither eosinophils nor neutrophils require ATG 5‐dependent autophagy for extracellular DNA trap formation

Germič, N., Stojkov, D., Oberson, K., Yousefi, S., & Simon, H. (2017) · Immunology · doi:10.1111/imm.12790 · Cited by 93 · see citing works

Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation

Fonseca, Z., Díaz-Godínez, C., Mora, N., Alemán, O. R., Uribe‐Querol, E., Carrero, J. C., & Rosales, C. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00226 · Cited by 87 · see citing works

Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2

Domingo-Gonzalez, R., Martínez-Colón, G. J., Smith, A. J., Smith, C. K., Ballinger, M. N., Xia, M., Murray, S., Kaplan, M. J., Yanik, G. A., & Moore, B. B. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201501-0161oc · Cited by 82 · see citing works

Hyperosmolar Stress Induces Neutrophil Extracellular Trap Formation: Implications for Dry Eye Disease

Tibrewal, S., Ivanir, Y., Sarkar, J., Nayeb-Hashemi, N., Bouchard, C. S., Kim, J. E., & Jain, S. K. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15332 · Cited by 81 · see citing works

Increased levels of neutrophil extracellular trap remnants in the serum of patients with rheumatoid arthritis

Wang, W., Peng, W., & Ning, X.-W. (2017) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13226 · Cited by 81 · see citing works

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs

Maueröder, C., Mahajan, A., Paulus, S., Gößwein, S., Hahn, J., Kienhöfer, D., Biermann, M. H. C., Tripal, P., Friedrich, R. P., Munoz, L. E., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00583 · Cited by 79 · see citing works

Hepatitis B Virus Inhibits Neutrophil Extracellular Trap Release by Modulating Reactive Oxygen Species Production and Autophagy

Hu, S., Liu, X., Gao, Y., Zhou, R., Wei, M., Dong, J., Yan, H., & Zhao, Y. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800871 · Cited by 69 · see citing works

Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis

de Bont, C. M., Stokman, M. E. M., Faas, P. P. M., Thurlings, R. M., Boelens, W. C., Wright, H. L., & Pruijn, G. J. M. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102484 · Cited by 64 · see citing works

Enhanced formation of neutrophil extracellular traps in Kawasaki disease

Yoshida, Y., Takeshita, S., Kawamura, Y., Kanai, T., Tsujita, Y., & Nonoyama, S. (2020) · Pediatric Research · doi:10.1038/s41390-019-0710-3 · Cited by 61 · see citing works

Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis

Nadesalingam, A., Chen, J. H. K., Farahvash, A., & Khan, M. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00359 · Cited by 59 · see citing works

The counter-intuitive role of the neutrophil in the acute respiratory distress syndrome

Vassallo, A. M., Wood, A. J. T., Subburayalu, J., Summers, C., & Chilvers, E. R. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz024 · Cited by 59 · see citing works

Neutrophil Extracellular Traps and Microcrystals

Rada, B. (2017) · Journal of Immunology Research · doi:10.1155/2017/2896380 · Cited by 58 · see citing works

Effect of Transient and Permanent Permeability Transition Pore Opening on NAD(P)H Localization in Intact Cells

Dumas, J., Argaud, L., Cottet‐Rousselle, C., Vial, G., Dahout-Gonzalez, C., Détaille, D., Leverve, X. M., & Fontaine, E. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900926200 · Cited by 57 · see citing works

Distinct Susceptibilities of Corneal Pseudomonas aeruginosa Clinical Isolates to Neutrophil Extracellular Trap-Mediated Immunity

Shan, Q., Dwyer, M., Rahman, S., & Gadjeva, M. G. (2014) · Infection and Immunity · doi:10.1128/iai.02169-14 · Cited by 48 · see citing works

Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease

Tintinger, G. R., Theron, A. J., Steel, H. C., & Anderson, R. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01447.x · Cited by 47 · see citing works

Low concentration of uncouplers of oxidative phosphorylation decreases the TNF-induced endothelial permeability and lethality in mice

Zakharova, V., Pletjushkina, O. Y., Galkin, I. I., Zinovkin, R. A., Chernyak, B. V., Krysko, D. V., Bachert, C., Krysko, O., Skulachev, V. P., & Popova, E. N. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.024 · Cited by 42 · see citing works

Protein disulfide isomerase and Nox: new partners in redox signaling

Trevelin, S. C., & Lopes, L. R. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666151029112523 · Cited by 37 · see citing works

Neutrophil extracellular traps involvement in corneal fungal infection.

Jin, X., Zhao, Y., Zhang, F., Wan, T., Fan, F., Xie, X., & Lin, Z. (2016) · Europe PMC (PubMed Central) · Cited by 34 · see citing works

Involvement of multiple kinases in neutrophil activation.

Dj, L., Furuya, W., & Grinstein, S. (1993) · PubMed · Cited by 29 · see citing works

NADPH Oxidase Modulates Ca2+-Dependent Formation of Neutrophil Extracellular Traps

Vorobjeva, N. V., & Chernyak, B. V. (2020) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392520030104 · Cited by 9 · see citing works

Macrophages in immunoregulation and therapeutics

Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,348 · see citing works

Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances

Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 939 · see citing works

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603 · see citing works

Neutrophil extracellular traps in homeostasis and disease

Wang, H., Kim, S. J., Yu, L., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 579 · see citing works

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 435 · see citing works

Diversity and complexity of cell death: a historical review

Park, W., Wei, S., Kim, B., Kim, B., Bae, S., Chae, Y. C., Ryu, D., & Ha, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01078-x · Cited by 364 · see citing works

T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

Hirschhorn, D., Budhu, S., Kraehenbuehl, L., Gigoux, M., Schröder, D., Chow, A. T., Ricca, J. M., Gasmi, B., Henau, O. D., Mangarin, L. M. B., et al. (2023) · Cell · doi:10.1016/j.cell.2023.03.007 · Cited by 306 · see citing works

The Immune and Regenerative Response to Burn Injury

Burgess, M., Valdera, F. A., Varon, D. E., Kankuri, E. M., & Nuutila, K. (2022) · Cells · doi:10.3390/cells11193073 · Cited by 241 · see citing works

Neutrophil Extracellular Traps Activate Proinflammatory Functions of Human Neutrophils

Dömer, D., Walther, T., Möller, S., Behnen, M., & Laskay, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636954 · Cited by 223 · see citing works

The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

Vo, T. T. T., Peng, T., Nguyen, T. H., Bui, T. N. H., Wang, C., Lee, W.-J., Chen, Y., Wu, Y.-C., & Lee, I. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01726-3 · Cited by 199 · see citing works

The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

Taifour, T., Attalla, S. S., Zuo, D., Gu, Y., Sanguin‐Gendreau, V., Proud, H., Solymoss, E., Bui, T., Kuasne, H., Papavasiliou, V., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.11.002 · Cited by 178 · see citing works

Selective activation of PFKL suppresses the phagocytic oxidative burst

Amara, N., Cooper, M. P., Voronkova, M. A., Webb, B. A., Lynch, E. M., Kollman, J. M., Ma, T., Yu, K., Lai, Z., Sangaraju, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.004 · Cited by 158 · see citing works

The Role of Reactive Species on Innate Immunity

Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works

Role of Neutrophil Extracellular Traps in Health and Disease Pathophysiology: Recent Insights and Advances

Islam, M. M., & Takeyama, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115805 · Cited by 130 · see citing works

Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

Hu, X., Li, Z., Lin, R., Shan, J.-Q., Yu, Q., Wang, R., Liao, L., Yan, W., Zhen, W., Shang, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634690 · Cited by 127 · see citing works

Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis

Chen, Z., Zhang, H., Qu, M., Nan, K., Cao, H., Cata, J. P., Chen, W., & Miao, C. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.653228 · Cited by 126 · see citing works

Toll-like receptor 4: A potential therapeutic target for multiple human diseases

Wei, J., Zhang, Y., Li, H., Wang, F., & Yao, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115338 · Cited by 120 · see citing works

Mitochondria Related Cell Death Modalities and Disease

Tian, C., Liu, Y., Li, Z., Zhu, P., & Zhao, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.832356 · Cited by 113 · see citing works

Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy

Loftus, L. V., Amend, S. R., & Pienta, K. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094723 · Cited by 112 · see citing works

Piezo1 expression in neutrophils regulates shear-induced NETosis

Baratchi, S., Danish, H., Chheang, C., Zhou, Y., Huang, A., Lai, A., Khanmohammadi, M., Quinn, K. M., Khoshmanesh, K., & Peter, K. (2024) · Nature Communications · doi:10.1038/s41467-024-51211-1 · Cited by 109 · see citing works

Significance of NETs Formation in COVID-19

Janiuk, K., Jabłońska, E., & Garley, M. (2021) · Cells · doi:10.3390/cells10010151 · Cited by 100 · see citing works

Neutrophil extracellular traps in wound healing

Zhu, Z., Zhou, S., Li, S., Gong, S., & Zhang, Q. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.09.007 · Cited by 99 · see citing works

Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers

Pangeni, R., Meng, T., Poudel, S., Sharma, D., Hutsell, H., Ma, J., Rubin, B. K., Longest, P. W., Hindle, M., & Xu, Q. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122661 · Cited by 98 · see citing works

Pathogenic cellular and molecular mediators in lupus nephritis

Mohan, C., Zhang, T., & Putterman, C. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00722-z · Cited by 92 · see citing works

ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions

Chen, Y.-S., Tian, H., Rong, D., Wang, L., Chen, S., Zeng, J., Xu, H., Mei, J., Wang, L.-Y., Liou, Y., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00338-8 · Cited by 87 · see citing works

Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Wan, Y., Shen, J., Ouyang, J., Dong, P., Hong, Y., Liang, L., & Liu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1025861 · Cited by 80 · see citing works

Inflammation: a matter of immune cell life and death

Bender, E. C., Tareq, H. S., & Suggs, L. J. (2025) · npj Biomedical Innovations. · doi:10.1038/s44385-025-00010-4 · Cited by 80 · see citing works

Methods for the Assessment of NET Formation: From Neutrophil Biology to Translational Research

Stoimenou, M., Tzoros, G., Skendros, P., & Chrysanthopoulou, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415823 · Cited by 79 · see citing works

Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus

Valencia, I., Lumpuy‐Castillo, J., Magalhães, G. S., Sánchez‐Ferrer, C. F., Lorenzo, Ó., & Peiró, C. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02097-8 · Cited by 78 · see citing works

Neutrophil Extracellular Traps in Cerebral Ischemia/Reperfusion Injury: Friend and Foe

Luo, H., Guo, H., Zhou, Y., Fang, R., Zhang, W., & Mei, Z. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230308090351 · Cited by 76 · see citing works

Neutrophil autophagy and NETosis in COVID-19: perspectives

Zhang, R., Sun, C., Han, Y., Huang, L., Sheng, H., Wang, J., Zhang, Y., Lai, J., Yuan, J., Chen, X., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2099206 · Cited by 75 · see citing works

Host-Directed Therapies for Tuberculosis

Jeong, E.-K., Lee, H.-J., & Jung, Y. (2022) · Pathogens · doi:10.3390/pathogens11111291 · Cited by 74 · see citing works

Multitasking functions of bacterial extracellular DNA in biofilms

Sharma, D. K., & Rajpurohit, Y. S. (2024) · Journal of Bacteriology · doi:10.1128/jb.00006-24 · Cited by 73 · see citing works

Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases

Manoj, H., Gomes, S. M., Thimmappa, P. Y., Nagareddy, P. R., Jamora, C., & Joshi, M. B. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.12.001 · Cited by 72 · see citing works

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

Paget, C., Doz, E., Winter, N., & Briard, B. (2022) · Cells · doi:10.3390/cells11071188 · Cited by 67 · see citing works

NETosis: an emerging therapeutic target in renal diseases

Juha, M., Molnár, A., Jakus, Z., & Ledó, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253667 · Cited by 65 · see citing works

The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection

Conceição‐Silva, F., Reis, C. S. M., Luca, P. M. D., Leite-Silva, J., Santiago, M. A., Morrot, A., & Morgado, F. N. (2021) · Cells · doi:10.3390/cells10081891 · Cited by 63 · see citing works

Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

Zhai, M., Gong, S., Luan, P., Shi, Y., Kou, W., Zeng, Y., Shi, J., Yu, G., Hou, J., Yu, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35330-1 · Cited by 63 · see citing works

Enterococcus faecalis in secondary apical periodontitis: Mechanisms of bacterial survival and disease persistence

Elashiry, M. M., Bergeron, B. E., & Tay, F. R. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106337 · Cited by 63 · see citing works

Neutrophil extracellular traps in cancer

Ma, Y., Wei, J., He, W., & Ren, J. (2024) · MedComm · doi:10.1002/mco2.647 · Cited by 62 · see citing works

Neutrophil Extracellular Traps Promote Metastases of Colorectal Cancers through Activation of ERK Signaling by Releasing Neutrophil Elastase

OKAMOTO, M. T., Mizuno, R., Kawada, K., Itatani, Y., Kiyasu, Y., Hanada, K., Hirata, W., Nishikawa, Y., Masui, H., Sugimoto, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021118 · Cited by 61 · see citing works

NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension

Krishnan, J., Hennen, E. M., Ao, M., Kirabo, A., Ahmad, T., de la Visitación, N., & Patrick, D. M. (2024) · Circulation Research · doi:10.1161/circresaha.123.323897 · Cited by 61 · see citing works

NETosis as an oncologic therapeutic target: a mini review

Jaboury, S., Wang, K., O’Sullivan, K. M., Ooi, J. D., & Ho, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1170603 · Cited by 59 · see citing works

Particulate matter (PM10) induces in vitro activation of human neutrophils, and lung histopathological alterations in a mouse model

Valderrama, A., Ortiz-Hernández, P., Agraz‐Cibrián, J. M., Tabares-Guevara, J. H., Gómez-Gallego, D. M., Zambrano‐Zaragoza, J. F., Taborda, N. A., & Hernández, J. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-11553-6 · Cited by 58 · see citing works

DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma

Song, M., Zhang, C., Cheng, S., Ouyang, D., Ping, Y., Yang, J., Zhang, Y., Tang, Y., Chen, H., Wang, Q.-J., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2986 · Cited by 57 · see citing works

Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury

Saisorn, W., Saithong, S., Phuengmaung, P., Udompornpitak, K., Bhunyakarnjanarat, T., Visitchanakun, P., Charoensappakit, A., Pisitkun, P., Chiewchengchol, D., & Leelahavanichkul, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669162 · Cited by 57 · see citing works

A targetable pathway in neutrophils mitigates both arterial and venous thrombosis

Nayak, L. V., Sweet, D. R., Thomas, A., Lapping, S. D., Kalikasingh, K. A., Madera, A., Vinayachandran, V., Padmanabhan, R., Vasudevan, N. T., Myers, J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7465 · Cited by 56 · see citing works

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation

Kwon, E.-J., & Ju, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910576 · Cited by 55 · see citing works

A Specific Calprotectin Neo-epitope [CPa9-HNE] in Serum from Inflammatory Bowel Disease Patients Is Associated with Neutrophil Activity and Endoscopic Severity

Mortensen, J. H., Sinkevičiūtė, D., Manon‐Jensen, T., Domislović, V., McCall, K., Thudium, C. S., Brinar, M., Önnerfjord, P., Goodyear, C. S., Krznarić, Ž., et al. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac047 · Cited by 54 · see citing works

Tissue factor in COVID-19-associated coagulopathy

Subramaniam, S., Kothari, H., & Bosmann, M. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.09.025 · Cited by 53 · see citing works

Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

Sounbuli, K., Mironova, N. L., & Alekseeva, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415827 · Cited by 53 · see citing works

Neutrophil extracellular traps mediate cardiomyocyte ferroptosis via the Hippo–Yap pathway to exacerbate doxorubicin-induced cardiotoxicity

Zhao, P., Li, Y., Xu, X., Yang, H., Li, X., Fu, S., Guo, Z., Zhang, J., Li, H., & Tian, J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05169-4 · Cited by 53 · see citing works

Polysialic Acid in the Immune System

Villanueva-Cabello, T. M., Gutiérrez-Valenzuela, L. D., Salinas-Marín, R., López-Guerrero, D. V., & Martínez-Duncker, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.823637 · Cited by 50 · see citing works

Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis

Zhou, X., Jin, S., Pan, J., Lin, Q., Yang, S., Ambe, P. C., Basharat, Z., Zimmer, V., Wang, W., & Hong, W. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.927193 · Cited by 51 · see citing works

Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses

Richards, C. M., McRae, S. A., Ranger, A. L., & Klegeris, A. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0091 · Cited by 50 · see citing works

Dihydrotanshinone I Inhibits the Lung Metastasis of Breast Cancer by Suppressing Neutrophil Extracellular Traps Formation

Zhao, H., Liang, Y., Sun, C., Zhai, Y., Li, X., Jiang, M., Yang, R., Li, X., Shu, Q., Kai, G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315180 · Cited by 50 · see citing works

Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice

Zeineddine, H. A., Hong, S., Peesh, P., Dienel, A., Torres, K., Pandit, P. T., Matsumura, K., Huang, S., Li, W., Chauhan, A., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320224 · Cited by 50 · see citing works

Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion

Tuz, A. A., Ghosh, S., Karsch, L., Ttoouli, D., Sata, S. P., Ulusoy, Ö., Kraus, A., Hoerenbaum, N., Wolf, J.-N., Lohmann, S., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00462-8 · Cited by 50 · see citing works

Neutrophils and Influenza: A Thin Line between Helpful and Harmful

George, S. T., Lai, J., Ma, J., Stacey, H. D., Miller, M. S., & Mullarkey, C. E. (2021) · Vaccines · doi:10.3390/vaccines9060597 · Cited by 50 · see citing works

Inflammatory myopathies and beyond: The dual role of neutrophils in muscle damage and regeneration

Torres-Ruiz, J. J., Alcalá‐Carmona, B., Alejandre‐Aguilar, R., & Gómez‐Martín, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1113214 · Cited by 48 · see citing works

Different Ways to Die: Cell Death Pathways and Their Association With Spinal Cord Injury

Guha, L., Singh, N., & Kumar, H. (2023) · Neurospine · doi:10.14245/ns.2244976.488 · Cited by 47 · see citing works

Neutrophils at the crossroads of acute viral infections and severity

Rawat, S., Vrati, S., & Banerjee, A. K. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100996 · Cited by 47 · see citing works

Molecular Prerequisites for Neutrophil Extracellular Trap Formation and Evasion Mechanisms of Staphylococcus aureus

von Köckritz‐Blickwede, M., & Winstel, V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.836278 · Cited by 46 · see citing works

The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis of Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak, T. M., & Nurbaeva, K. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713581 · Cited by 46 · see citing works

Regulating Neutrophil PAD4/NOX-Dependent Cerebrovasular Thromboinflammation

Ansari, J., Vital, S. A., Yadav, S., & Gavins, F. N. E. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.77434 · Cited by 44 · see citing works

Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy

Farhan, A., Hassan, G., Ali, S. H. L., Yousaf, Z., Shafique, K., Faisal, A., Younis, B. B., & Mirza, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1076690 · Cited by 43 · see citing works

Neutrophil biology in injuries and diseases of the central and peripheral nervous systems

Balog, B. M., Sonti, A., & Zigmond, R. E. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102488 · Cited by 43 · see citing works

Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps

Bautista-Becerril, B., Campi-Caballero, R., Sevilla-Fuentes, S., Hernández-Regino, L. M., Hanono, A., Flores-Bustamante, A., González-Flores, J., García-Ávila, C. A., Aquino‐Gálvez, A., Castillejos-López, M. D. J., et al. (2021) · Biomolecules · doi:10.3390/biom11050694 · Cited by 43 · see citing works

NETosis and SARS-COV-2 infection related thrombosis: a narrative review

Behzadifard, M., & Soleimani, M. (2022) · Thrombosis Journal · doi:10.1186/s12959-022-00375-1 · Cited by 43 · see citing works

Protein Kinase C Isoforms Mediate the Formation of Neutrophil Extracellular Traps

Vorobjeva, N. V., Dagil, Y. A., Pashenkov, M. V., Pinegin, B. V., & Chernyak, B. V. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109448 · Cited by 43 · see citing works

The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis

Czerwińśka, J., & Owczarczyk-Saczonek, A. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031840 · Cited by 41 · see citing works

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Accipe, L., Abadie, A., Nevière, R., & Bercion, S. (2023) · Antioxidants · doi:10.3390/antiox12051079 · Cited by 40 · see citing works

Assessing Humoral Immuno-Inflammatory Pathways Associated with Respiratory Failure in COVID-19 Patients

Regolo, M., Sorce, A., Vaccaro, M., Colaci, M., Stancanelli, B., Natoli, G., Motta, M., Isaia, I., Castelletti, F., Giangreco, F., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12124057 · Cited by 40 · see citing works

Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics

Li, H., Li, C., Fu, C., Wang, Y., Liang, T., Wu, H., Wu, C., Wang, C., Sun, T., & Liu, S. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03195-3 · Cited by 39 · see citing works

SARS-CoV-2 Infection Dysregulates Host Iron (Fe)-Redox Homeostasis (Fe-R-H): Role of Fe-Redox Regulators, Ferroptosis Inhibitors, Anticoagulants, and Iron-Chelators in COVID-19 Control

Naidu, S. A. G., Clemens, R., & Naidu, A. S. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2022.2075072 · Cited by 38 · see citing works

Therapeutic and diagnostic applications of nanoparticles in the management of COVID-19: a comprehensive overview

Gholizadeh, O., Yasamineh, S., Amini, P., Afkhami, H., Delarampour, A., Akbarzadeh, S., Matloub, R. K., Zahedi, M., Hosseini, P., Hajiesmaeili, M., et al. (2022) · Virology Journal · doi:10.1186/s12985-022-01935-7 · Cited by 38 · see citing works

Comprehensive landscape of cell death mechanisms: from molecular cross-talk to therapeutic innovation in oncology

Ke, Q., Mu, Y., Hu, Y., Li, J., & Liu, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1611055 · Cited by 37 · see citing works

Cytokine Storm of COVID-19 and its Impact on Patients with and without Chronic Liver Disease

Premkumar, M., & Kedarisetty, C. K. (2021) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00055 · Cited by 37 · see citing works

Role of NETosis in Central Nervous System Injury

Chen, Y., Zhang, H., Hu, X., Cai, W., Ni, W., & Zhou, K. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3235524 · Cited by 37 · see citing works

Modern concept of autoimmunity in rheumatology

Nasonov, E. L. (2023) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2023-397-420 · Cited by 37 · see citing works

Apoptotic signaling: Beyond cell death

Nano, M., & Montell, D. J. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.11.002 · Cited by 37 · see citing works

Mechanisms of neutrophil extracellular trap in chronic inflammation of endothelium in atherosclerosis

Yang, X., Ma, Y., Chen, X., Zhu, J., Xue, W., & Ning, K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121867 · Cited by 36 · see citing works

Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

Cavalcante, J. S., de Almeida, D. E. G., Santos‐Filho, N. A., Sartim, M. A., Baldo, A. D. A., Brasileiro, L., Albuquerque, P. L. M. M., de Oliveira, S. S., Sachett, J. D. A. G., Monteiro, W. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411508 · Cited by 35 · see citing works

DNase based therapeutic approaches for the treatment of NETosis related inflammatory diseases

Yadav, R., Momin, A., & Godugu, C. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110846 · Cited by 35 · see citing works

The Impact of Pathogens on Sepsis Prevalence and Outcome

Dyck, B., Unterberg, M., Adamzik, M., & Koos, B. (2024) · Pathogens · doi:10.3390/pathogens13010089 · Cited by 35 · see citing works

Neutrophils in glioma microenvironment: from immune function to immunotherapy

Sun, C., Wang, S., Ma, Z., Zhou, J., Ding, Z., Yuan, G., & Pan, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1393173 · Cited by 35 · see citing works

Exploring the Role of Immune System and Inflammatory Cytokines in SARS-CoV-2 Induced Lung Disease: A Narrative Review

Tirelli, C., AMICI, M. D., Albrici, C., Mira, S., Nalesso, G., Re, B., Corsico, A. G., Mondoni, M., & Centanni, S. (2023) · Biology · doi:10.3390/biology12020177 · Cited by 34 · see citing works

Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos

Zhou, R., Guo, J., & Jin, Z. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02713-z · Cited by 35 · see citing works

The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death

Xie, J., Yuan, C., Yang, S., Ma, Z., Li, W., Mao, L., Jiao, P., & Liu, W. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00659-6 · Cited by 34 · see citing works

Exploring the involvement of serine proteases in neutrophil extracellular traps: a review of mechanisms and implications

Korba-Mikołajczyk, A., Służalska, K. D., & Kasperkiewicz, P. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07857-w · Cited by 34 · see citing works

Extrusion of mitochondria: Garbage clearance or cell–cell communication signals?

Lyamzaev, K. G., Zinovkin, R. A., & Chernyak, B. V. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30711 · Cited by 34 · see citing works

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Li, C., Wu, C., Li, F., Xu, W., Zhang, X., Huang, Y., & Xia, D. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s460333 · Cited by 33 · see citing works

The disruptive role of LRG1 on the vasculature and perivascular microenvironment

Dritsoula, A., Camilli, C., Moss, S. E., & Greenwood, J. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1386177 · Cited by 30 · see citing works

Crosstalk between oxidative stress, mitochondrial dysfunction, chromosome instability, and the activation of the cGAS-STING/IFN pathway in systemic sclerosis

Waseem, M., Imtiaz, A., Alexander, A., Graham, L. V. D., & Contreras-Galindo, R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102812 · Cited by 33 · see citing works

Role of Neutrophils on the Ocular Surface

Mun, Y., Hwang, J. S., & Shin, Y. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910386 · Cited by 33 · see citing works

Novel perception of neutrophil extracellular traps in gouty inflammation

Tan, H., Li, Z., Zhang, S., Zhang, J., & Jia, E. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109642 · Cited by 32 · see citing works

Bacterial redox response factors in the management of environmental oxidative stress

Sudharsan, M., Prasad, N. R., & Rajendrasozhan, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03456-5 · Cited by 31 · see citing works

Stages of NETosis Development upon Stimulation of Neutrophils with Activators of Different Types

Inozemtsev, V. A., Sergunova, V. A., Vorobjeva, N. V., Kozlova, E. K., Sherstyukova, E. A., Kandrashina, S., & Черныш, А. М. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512355 · Cited by 30 · see citing works

The Mechanisms of Regulated Cell Death: Structural and Functional Proteomic Pathways Induced or Inhibited by a Specific Protein—A Narrative Review

Fernández‐Lázaro, D., Sanz, B., & Seco‐Calvo, J. (2024) · Proteomes · doi:10.3390/proteomes12010003 · Cited by 30 · see citing works

NETosis in ischemic/reperfusion injuries: An organ-based review

Hashemi, P., Nouri‐Vaskeh, M., Alizadeh, L., Baghbanzadeh, A., Badalzadeh, R., Askari, E., & Baradaran, B. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120158 · Cited by 29 · see citing works

Neutrophil extracellular traps: new aspects

Воробьева, Н. В. (2020) · Bulletin of Moscow University, Series 16. Biology (Moscow University) · Cited by 25 · see citing works

Нейтрофильные внеклеточные ловушки: новые аспекты

Воробьева, Н. В. (2020) · Вестник Московского университета. Серия 16. Биология

Could Neutrophil Extracellular Traps Elucidate the Mysteries of Pathogenesis?

hafez, A. A. E. (2014) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.1000174 · Cited by 3 · see citing works

Multi-facets of neutrophil extracellular trap in infectious diseases: Moving beyond immunity

Tabrizi, Z. A., Khosrojerdi, A., Aslani, S., Hemmatzadeh, M., Babaie, F., Bairami, A., Shomali, N., Hosseinzadeh, R., Safari, R., & Mohammadi, H. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105066 · Cited by 39 · see citing works

Molecular mechanisms and therapeutic target of NETosis in diseases

Huang, J., Hong, W., Wan, M., & Zheng, L. (2022) · MedComm · doi:10.1002/mco2.162 · Cited by 234 · see citing works