The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice
Open accessAbstract
SUMMARY “Triple-defective” (3d) mice carrying a mutation in UNC93B1, a chaperone for the endosomal nucleic-acid sensing (NAS) Toll-Like Receptors TLR3, TLR7 and TLR9, are highly susceptible to Toxoplasma gondii infection. However, none of the single or even the triple NAS-TLR deficient animals recapitulated the 3d susceptible phenotype to Toxoplasma infection. Investigating this further, we find that while parasite RNA and DNA activate innate immune responses via the NAS-TLRs 7 and 9, TLR11 and TLR12 working as heterodimers are required for sensing and responding to Toxoplasma profilin. Consequently, the triple TLR7/TLR9/TLR11 deficient mice are highly susceptible to T. gondii infection, recapitulating the phenotype of 3d mice. Humans lack functional TLR11 and TLR12 genes. Consistently, human cells produce high levels of pro-inflammatory cytokines in response to parasite derived RNA and DNA, but not to Toxoplasma profilin supporting a more critical role for NAS-TLRs in human toxoplasmosis.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 2×
“NAS-TLRs are important cognate receptors for viruses, bacteria, and different protozoan parasites (Alexopoulou et al., 2001; Bartholomeu et al., 2008; Benson et al., 2009; Caetano et al., 2011; Heil et al., 2004; Hemmi et al., 2000; Parroche et al., 2007).”
BackgroundRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Cited by
Toll-Like Receptor Signaling Pathways
Kawasaki, T., & Kawai, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00461 · Cited by 3,233
The history of toll-like receptors - redefining innate immunity
O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3446 · Cited by 1,765
Self-citationInnate immunity to Toxoplasma gondii infection
Yarovinsky, F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3598 · Cited by 462
Toll-like receptors: Activation, signalling and transcriptional modulation
De Nardo, D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.025 · Cited by 457
Dalod, M., Chelbi, R., Malissen, B., & Lawrence, T. (2014) · The EMBO Journal · doi:10.1002/embj.201488027 · Cited by 437
Metadata
- Authors
- Andrade, W. A., Souza, M. D. C., Ramos-Martinez, E., Nagpal, K., Dutra, M. S., Melo, M. B., Bartholomeu, D. C., Ghosh, S., Golenbock, D. T., & Gazzinelli, R. T.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 13
- Issue
- 1
- Pages
- 42-53
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1970279912
- Cited by
- 216
- References
- 2
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Andrade, W. A., Souza, M. D. C., Ramos-Martinez, E., Nagpal, K., Dutra, M. S., Melo, M. B., Bartholomeu, D. C., Ghosh, S., Golenbock, D. T., & Gazzinelli, R. T. (2013). Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2012.12.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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