The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System
Open accessAbstract
Summary Humans and mice infected with different Plasmodium strains are known to produce microvesicles derived from the infected red blood cells (RBC), denoted RMVs. Studies in mice have shown that RMVs are elevated during infection and have pro-inflammatory activity. Here we present a detailed characterization of RMV composition and function in the human malaria parasite Plasmodium falciparum. Proteomics profiling revealed the enrichment of multiple host and parasite proteins, in particular of parasite antigens associated with host cell membranes and proteins involved in parasite invasion into RBCs. RMVs are quantitatively released during the asexual parasite cycle prior to parasite egress. RMVs demonstrate potent immunomodulatory properties on human primary macrophages and neutrophils. Additionally, RMVs are internalized by infected red blood cells and stimulate production of transmission stage parasites in a dose-dependent manner. Thus, RMVs mediate cellular communication within the parasite population and with the host innate immune system.
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Citations
Cites
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Cited by
Efficient RNA drug delivery using red blood cell extracellular vesicles
Usman, W. M., Pham, T. C., Kwok, Y. Y., Vu, L. T., Ma, V., Peng, B., Chan, Y. S., Wei, L., Chin, S. M., Azad, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04791-8 · Cited by 663
The function and clinical application of extracellular vesicles in innate immune regulation
Zhou, X., Xie, F., Wang, L., Zhang, L., Zhang, S., Fang, M., & Zhou, F. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0391-1 · Cited by 294
Biology of Malaria Transmission
Meibalan, E., & Marti, M. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025452 · Cited by 251
Self-citationNew insights into malaria pathogenesis
Moxon, C. A., Gibbins, M. P., McGuinness, D., Milner, D. A., & Marti, M. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032640 · Cited by 207
Self-citationPregnancy-associated Malaria, Challenges and Prospects in Sub-Saharan Africa
Aguzie, I. O. N. (2018) · Clinics in Mother and Child Health · doi:10.4172/2090-7214.1000282 · Cited by 13
Metadata
- Authors
- Mantel, P.-Y., Hoang, A. N., Goldowitz, I., Potashnikova, D., Hamza, B., Vorobjev, I., Ghiran, I., Toner, M., Irimia, D., Ivanov, A. R., Barteneva, N., & Marti, M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 13
- Issue
- 5
- Pages
- 521-534
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2018122290
- Cited by
- 414
- References
- 1
- FWCI
- 33.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
