Revisiting Caspase-11 Function in Host Defense
Open accessAbstract
Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens. Using the new tools available, researchers are further elucidating the mechanisms by which caspase-11 contributes to host defense. Here, we review the emerging understanding of caspase-11 functions and the mechanisms of activation and discuss the implications for human disease.
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Cytosolic LPS from invading Gram-negative bacteria is a major trigger of pyroptosis.
“A large body of evidence indicates that cytosolic LPS from invading Gram-negative bacteria is a major trigger of pyroptosis.”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [618]
CASP11 is responsible for the CASP1-independent death of macrophages responding to Gram-negative bacterial infection.
“it has been shown that CASP11 is responsible for the CASP1-independent death of macrophages responding to Gram-negative bacterial infection [616–619].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [618]
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Adan, A. (2015) · İYTE (İZMİR YÜKSEK TEKNOLOJİ ENSTİTÜSÜ)
- Authors
- Ng, T. M., & Monack, D. M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Monack, Denise M.
- ORCID
- Monack, Denise M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 14
- Issue
- 1
- Pages
- 9-14
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC3785303
- OpenAlex
- W2074376389
- Cited by
- 32
- References
- 44
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI007328-25, F32AI008972, AI095396, R01AI089722, AI08972, R01AI095396, T32AI007328)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- caspase-11, innate immunity, host defense, caspase activation, host-pathogen interaction, human disease
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammation, Caspases, Caspases, Initiator, Host-Pathogen Interactions
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