Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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The Inflammasome

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Inflammasomes: mechanism of assembly, regulation and signalling

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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Pyroptosis: host cell death and inflammation

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Pore-forming activity and structural autoinhibition of the gasdermin family

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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

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Non-canonical inflammasome activation targets caspase-11

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Inflammatory caspases are innate immune receptors for intracellular LPS

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A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

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Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

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Pro-inflammatory programmed cell death

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

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Shigella flexneri induces apoptosis in infected macrophages

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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Molecular Cloning of the Interleukin-1β Converting Enzyme

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Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

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Pyroptotic cell death defends against intracellular pathogens

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

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MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

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Salmonella induces macrophage death by caspase‐1‐dependent necrosis

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Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

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Programmed necrosis in inflammation: Toward identification of the effector molecules

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Caspase-11 Protects Against Bacteria That Escape the Vacuole

Aachoui, Y., Leaf, I. A., Hagar, J. A., Fontana, M. F., Campos, C. G., Zak, D. E., Tan, M. H., Cotter, P. A., Vance, R. E., Aderem, A. A., et al. (2013) · Science · doi:10.1126/science.1230751 · Cited by 544 · see citing works

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

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Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

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Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

Sellin, M. E., Müller‐Hauser, A. A., Felmy, B., Dolowschiak, T., Diard, M., Tardivel, A., Maslowski, K. M., & Hardt, W. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.07.001 · Cited by 404 · see citing works

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

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Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

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Nonsyndromic hearing impairment is associated with a mutation in DFNA5

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Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

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Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy

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Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions

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Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner

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Distinctive expression and function of four GSDM family genes (GSDMA‐D) in normal and malignant upper gastrointestinal epithelium

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Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

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Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

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Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer

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Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE

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Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells

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Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

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Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

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Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells

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Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

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A Forward Genetics Screen in Mice Identifies Recessive Deafness Traits and Reveals That Pejvakin Is Essential for Outer Hair Cell Function

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GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-β-dependent apoptotic signalling

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The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage

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Loss of conserved Gsdma3 self-regulation causes autophagy and cell death

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The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3

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Truncating mutation of theDFNB59gene causes cochlear hearing impairment and central vestibular dysfunction

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Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis

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Anthrax Lethal Toxin Rapidly Activates Caspase-1/ICE and Induces Extracellular Release of Interleukin (IL)-1β and IL-18

Cordoba-Rodriguez, R., Fang, H., Lankford, C. S. R., & Frucht, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300539200 · Cited by 79 · see citing works

Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence

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A new mutation Rim3 resembling Re den is mapped close to retinoic acid receptor alpha (Rara) gene on mouse Chromosome 11

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Involvement ofDFNB59 mutations in autosomal recessive nonsyndromic hearing impairment

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Functional Conservation of Gsdma Cluster Genes Specifically Duplicated in the Mouse Genome

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Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

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Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells

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The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis

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Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles

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GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness

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Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development

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A yeast model for the study of human DFNA5, a gene mutated in nonsyndromic hearing impairment

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Delineating Immune-Mediated Mechanisms Underlying Hair Follicle Destruction in the Mouse Mutant Defolliculated

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Revisiting Caspase-11 Function in Host Defense

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A p.C343S missense mutation in PJVK causes progressive hearing loss

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199 · see citing works

NLRP3 inflammasome activation and cell death

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Lysosomes as dynamic regulators of cell and organismal homeostasis

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Inflammasomes in neuroinflammatory and neurodegenerative diseases

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Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

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