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Cited by 547Cellular transport and secretionHIV Research and TreatmentVirology and Viral Diseases

Virus budding and the ESCRT pathway

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Votteler, Jörg, Sundquist, Wesley I.·2013·Cell Host & Microbe
DOI 10.1016/j.chom.2013.08.012PMC PMC3819203
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Abstract

Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cells, the ESCRT pathway catalyzes analogous membrane fission events required for the abscission stage of cytokinesis and for a series of "reverse topology" vesiculation events. Studies of enveloped virus budding are therefore providing insights into the complex cellular mechanisms of cell division and membrane protein trafficking (and vice versa). Here, we review how viruses mimic cellular recruiting signals to usurp the ESCRT pathway, discuss mechanistic models for ESCRT pathway functions, and highlight important research frontiers.

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  • To achieve efficient release, retroviruses hijack the host cell's ESCRT machinery, a cellular system typically involved in membrane remodeling and vesicle trafficking.

    “To achieve efficient release, retroviruses hijack the host cell’s endosomal sorting complexes required for transport (ESCRT) machinery, a cellular system typically involved in membrane remodeling and vesicle trafficking”

    From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Votteler and Sundquist 2013

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Cited by

Sorted by citations

Authors
Votteler, J., & Sundquist, W. I.
Affiliations
University of Utah (US)
Corresponding author
Sundquist, Wesley I.
ORCID
Sundquist, Wesley I.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2013-09
Volume
14
Issue
3
Pages
232-241
ISSN
1931-3128 (ISSN-L)
DOI
10.1016/j.chom.2013.08.012
PMC
PMC3819203
OpenAlex
W2074130602
Cited by
547
References
9
Citations by year
2026: 18 · 2025: 32 · 2024: 47 · 2023: 39 · 2022: 40 · 2021: 64 · 2020: 55 · 2019: 46 · 2018: 54 · 2017: 35 · 2016: 39 · 2015: 44 · 2014: 32 · 2013: 2
FWCI
4.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (GM 082545, P50GM082545, P01GM066521)
  • National Institute of Allergy and Infectious Diseases (AI-051174, R01AI051174, R37AI051174)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
viral budding, ESCRT pathway, enveloped viruses, HIV, membrane fission, membrane trafficking, host-virus interaction
MeSH terms
Animals, Humans, Models, Biological, Retroviridae, Host-Pathogen Interactions, Endosomal Sorting Complexes Required for Transport, Virus Release

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