The Dichotomous Role of Extracellular Vesicles in the Central Nervous System

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Shedding light on the cell biology of extracellular vesicles

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Parkinson disease

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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Neuropathological alterations in Alzheimer disease

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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

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Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

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Routes and mechanisms of extracellular vesicle uptake

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The blood-brain barrier: Bottleneck in brain drug development

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Rab27a and Rab27b control different steps of the exosome secretion pathway

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Membrane Fusion

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Amyotrophic lateral sclerosis

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Exosomes as drug delivery vehicles for Parkinson’s disease therapy

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Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development

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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

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Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

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Alzheimer's disease

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Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

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Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

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Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

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Alzheimer’s disease β-amyloid peptides are released in association with exosomes

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Membrane Fusion

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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

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Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

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Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

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Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

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Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

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Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

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Active Wnt proteins are secreted on exosomes

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Cells release prions in association with exosomes

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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Cellular Internalization of Exosomes Occurs Through Phagocytosis

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Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

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Exosomal cell-to-cell transmission of alpha synuclein oligomers

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Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

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Membrane budding and scission by the ESCRT machinery: it's all in the neck

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Multivesicular Endosome Biogenesis in the Absence of ESCRTs

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Extracellular vesicles round off communication in the nervous system

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Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

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Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol

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Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

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The release and trans-synaptic transmission of Tau via exosomes

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The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

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Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

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Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

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Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

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Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

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Exosomes: Novel Biomarkers for Clinical Diagnosis

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Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

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Virus budding and the ESCRT pathway

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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

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Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

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Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

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Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

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Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

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Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA

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The ESCRT machinery

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Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

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Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells

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Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

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Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

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The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

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Exosome secretion is a key pathway for clearance of pathological TDP-43

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Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

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Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification

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Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

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Exosomes as mediators of neuroinflammation

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TDP-43 is intercellularly transmitted across axon terminals

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Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

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Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

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Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

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Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

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Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

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