The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut
Open accessAbstract
Summary Genomic and metagenomic sequencing efforts, including human microbiome projects, reveal that microbes often encode multiple systems that appear to accomplish the same task. Whether these predictions reflect actual functional redundancies is unclear. We report that the prominent human gut symbiont Bacteroides thetaiotaomicron employs three functional, homologous vitamin B12 transporters that in at least two cases confer a competitive advantage in the presence of distinct B12 analogs (corrinoids). In the mammalian gut, microbial fitness can be determined by the presence or absence of a single transporter. The total number of distinct corrinoid transporter families in the human gut microbiome likely exceeds those observed in B. thetaiotaomicron by an order of magnitude. These results demonstrate that human gut microbes use elaborate mechanisms to capture and differentiate corrinoids in vivo and that apparent redundancies observed in these genomes can instead reflect hidden specificities that determine whether a microbe will colonize its host.
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Cites
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Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Obesity alters gut microbial ecology
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A framework for human microbiome research
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Siderophore-Based Iron Acquisition and Pathogen Control
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Glycan foraging in vivo by an intestine-adapted bacterial symbiont
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Cited by
Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance
Moya, A., & Ferrer, M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.02.002 · Cited by 690
An insider's perspective: Bacteroides as a window into the microbiome
Wexler, A. G., & Goodman, A. L. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.26 · Cited by 641
Self-citationThe evolution of cooperation within the gut microbiota
Rakoff-Nahoum, S., Foster, K. R., & Comstock, L. E. (2016) · Nature · doi:10.1038/nature17626 · Cited by 616
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Green, C. R., Wallace, M., Divakaruni, A. S., Phillips, S. A., Murphy, A. N., Ciaraldi, T. P., & Metallo, C. M. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.1961 · Cited by 471
Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review
Yang, Q., Liang, Q., Balakrishnan, B., Belobrajdic, D. P., Feng, Q.-J., & Zhang, W. (2020) · Nutrients · doi:10.3390/nu12020381 · Cited by 466
Metadata
- Authors
- Degnan, P. H., Barry, N. A., Mok, K. C., Taga, M. E., & Goodman, A. L.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 15
- Issue
- 1
- Pages
- 47-57
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2086335460
- Cited by
- 283
- References
- 6
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Degnan, P. H., Barry, N. A., Mok, K. C., Taga, M. E., & Goodman, A. L. (2014). Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2013.12.007
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