Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance
Abstract
The microbiota should be considered as just another component of the human epigenetic landscape. Thus, health is also a reflection of the diversity and composition of gut microbiota and its metabolic status. In defining host health, it remains unclear whether diversity is paramount, or whether greater weight is held by gut microbiota composition or mono- or multiple-functional capacity of the different taxa and the mechanisms involved. A network-biology approach may shed light on the key gut players acting to protect against, or promote, disorders or diseases. This could be achieved by integrating data on total and active species, proteins and molecules, and their association with host response. In this review, we discuss the utilization of top-down and bottom-up approaches, following a functional hierarchy perspective.
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Functional redundancy allows the host to maintain a healthy gut microbiota to preserve stability and resilience in response to perturbations.
“Functional redundancy allows the host to maintain a healthy gut microbiota to preserve stability and resilience in response to perturbations [13, 14].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [13]
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Rouanet, A., Bolca, S., Bru, A., Claes, I., Cvejic, H., Girgis, H., Harper, A., Lavergne, S. N., Mathys, S., Pane, M., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00237 · Cited by 120 · see citing works
Maternal modifiers of the infant gut microbiota: Metabolic consequences
Mulligan, C. M., & Friedman, J. E. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0303 · Cited by 101 · see citing works
Horrocks, V., King, O. G., Yip, A. Y. G., Marques, I. M., & McDonald, J. A. K. (2023) · Microbiology · doi:10.1099/mic.0.001377 · Cited by 104 · see citing works
Of microbes and minds: A narrative review on the second brain aging
Calvani, R., Picca, A., Lo Monaco, M. R., Landi, F., Bernabei, R., & Marzetti, E. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00053 · Cited by 92 · see citing works
Oral and Gut Dysbiosis Leads to Functional Alterations in Parkinson’s Disease
Jo, S., Kang, W., Hwang, Y. S., Lee, S. H., Park, K. W., Kim, M. S., Lee, H., Yoon, H. J., Park, Y. K., Chalita, M., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00351-6 · Cited by 85 · see citing works
Taxa-function robustness in microbial communities
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- Authors
- Moya, A., & Ferrer, M.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- ORCID
- Ferrer, Manuel
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 24
- Issue
- 5
- Pages
- 402-413
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2297247152
- Cited by
- 690
- References
- 73
- Citations by year
- 2026: 84 · 2025: 76 · 2024: 70 · 2023: 72 · 2022: 86 · 2021: 111 · 2020: 68 · 2019: 43 · 2018: 31 · 2017: 34 · 2016: 14
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, functional redundancy, microbial community stability, microbial diversity, microbial community composition, functional hierarchy, network biology, host-microbe interactions, epigenetic landscape, host health, top-down and bottom-up approaches
- MeSH terms
- Gastrointestinal Microbiome, Animals, Gastrointestinal Diseases, Humans, Gastrointestinal Tract, Biodiversity, Biota
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