The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection
Open accessAbstract
Summary The commensal microbiota impacts specific immune cell populations and their functions at peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut microbiota control immunity through regulation of hematopoiesis at primary immune sites. We reveal that germ-free mice display reduced proportions and differentiation potential ofspecific myeloid cellprogenitors of both yolk sac and bone marrow origin. Homeostaticinnate immune defects may lead to impaired early responses to pathogens. Indeed, following systemic infection with Listeria monocytogenes, germ-free and oral antibiotic treated mice display increased pathogen burden and acute death. Re-colonization of germ-free mice with a complex microbiota restores defects inmyelopoiesis and resistance to Listeria. Thesefindingsreveal that gut bacteriadirect innate immune cell development via promoting hematopoiesis, contributing to our appreciation of the deep evolutionary connection between mammals and their microbiota.
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Cited by
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
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Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
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The central nervous system and the gut microbiome
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Metadata
- Authors
- Khosravi, A., Yáñez, A., Price, J. G., Chow, A., Merad, M., Goodridge, H. S., & Mazmanian, S. K.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 15
- Issue
- 3
- Pages
- 374-381
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2066382988
- Cited by
- 644
- References
- 30
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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