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Cited by 331

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Filamentous Bacteriophage Promote Biofilm Assembly and Function

Open access
Secor, Patrick R., Sweere, Johanna M., Michaels, Lia A., Malkovskiy, Andrey V., Lazzareschi, Daniel, Katznelson, Ethan, Rajadas, Jayakumar, Birnbaum, Michael E., Arrigoni, Allison, Braun, Kathleen R., Evanko, Stephen P., Stevens, David A., Kaminsky, Werner, Singh, Pradeep K., Parks, William C., Bollyky, Paul L.·2015·Cell Host & Microbe
DOI 10.1016/j.chom.2015.10.013
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Abstract

Summary Biofilms - communities of bacteria encased in a polymer-rich matrix- confer bacteria with the ability to persist in pathologic host contexts, such as the cystic fibrosis (CF) airways. How bacteria assemble polymers into biofilms is largely unknown. We find that the extracellular matrix produced by Pseudomonas aeruginosa self-assembles into a liquid crystal through entropic interactions between polymers and filamentous Pf bacteriophages, which are long, negatively charged filaments. This liquid crystalline structure enhances biofilm function by increasing adhesion and tolerance to desiccation and antibiotics. Pf bacteriophages are prevalent amongst P. aeruginosa clinical isolates and were detected in CF sputum. The addition of Pf bacteriophage to sputum polymers or serum was sufficient to drive their rapid assembly into viscous liquid crystals. Fd, a related bacteriophage of Escherichia coli, has similar biofilm-building capabilities. Targeting filamentous bacteriophage or the liquid crystalline organization of the biofilm matrix may represent antibacterial strategies.

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Metadata

Authors
Secor, P. R., Sweere, J. M., Michaels, L. A., Malkovskiy, A. V., Lazzareschi, D., Katznelson, E., Rajadas, J., Birnbaum, M. E., Arrigoni, A., Braun, K. R., Evanko, S. P., Stevens, D. A., Kaminsky, W., Singh, P. K., Parks, W. C., & Bollyky, P. L.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2015-11
Volume
18
Issue
5
Pages
549-559
ISSN
1931-3128 (ISSN-L)
DOI
10.1016/j.chom.2015.10.013
OpenAlex
W2120137321
Cited by
331
References
40
FWCI
5.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Filamentous Bacteriophage Promote Biofilm Assembly and Function. https://app.cochat.ai/papers/10.1016/j.chom.2015.10.013
The paper
Secor, P. R., Sweere, J. M., Michaels, L. A., Malkovskiy, A. V., Lazzareschi, D., Katznelson, E., Rajadas, J., Birnbaum, M. E., Arrigoni, A., Braun, K. R., Evanko, S. P., Stevens, D. A., Kaminsky, W., Singh, P. K., Parks, W. C., & Bollyky, P. L. (2015). Filamentous Bacteriophage Promote Biofilm Assembly and Function. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2015.10.013

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.