The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
The cGAS-STING Defense Pathway and Its Counteraction by Viruses
Open accessAbstract
Summary Upon viral infection, host cells mount a concerted innate immune response involving type I interferon and pro-inflammatory cytokines to enable elimination of the pathogen. Recently cGAS and STING have been identified as intracellular sensors that activate the interferon pathway in response to virus infection and thus mediate host defense against a range of DNA and RNA viruses. Here we review how viruses are sensed by the cGAS-STING signaling pathway as well as how viruses modulate this pathway. Mechanisms utilized by viral proteins to inhibit cGAS and/or STING are also discussed. On the flip side, host cells have also evolved strategies to thwart viral immune escape. The balance between host immune control and viral immune evasion is pivotal to viral pathogenesis and we discuss this virus-host stand-off in the context of the cGAS-STING innate immune pathway.
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Cites
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
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“Of note, STING-deficient mice also show greater susceptibility to RNA virus (e.g., vesicular stomatitis virus [VSV]) infection and STING-deficient cells fail to mount a strong innate immune response against RNA viruses such as VSV and SeV (Ishikawa et al., 2009).”
InfluentialSelf-citationPhosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
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CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.
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Cited by
Molecular mechanisms and cellular functions of cGAS–STING signalling
Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052
The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
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Decoding type I and III interferon signalling during viral infection
Mesev, E. V., LeDesma, R. A., & Ploss, A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0421-x · Cited by 538
Optimizing oncolytic virotherapy in cancer treatment
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Metadata
- Authors
- Ma, Z., & Damania, B.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 19
- Issue
- 2
- Pages
- 150-158
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2260285999
- Cited by
- 445
- References
- 70
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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