Decoding type I and III interferon signalling during viral infection
Open accessAbstract
Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.
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The ability to fine-tune an IFN response is critical because both overactivation and underactivation are deleterious to the host.
“The ability to fine-tune an IFN response is critical because both its overactivation and underactivation are deleterious to the host (Mesev et al., 2019).”
From COVID-19 and the human innate immune system (2021) · cites this paper as Mesev et al., 2019
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Interferon-Stimulated Genes: What Do They All Do?
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COVID-19 and the human innate immune system
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A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice
Leist, S. R., Dinnon, K. H., Schäfer, A., Tse, L. V., Okuda, K., Hou, Y. J., West, A., Edwards, C. E., Sanders, W., Fritch, E. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.050 · Cited by 613 · see citing works
New insight into the agonism of protease-activated receptors as an immunotherapeutic strategy
Jiang, Y., & Lu, L. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105614 · Cited by 7 · see citing works
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Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
“Host responses upon receptor activation include the expression of interferons 105–107 (Table 3), specific inflammatory cytokines 108 , chemokines 109,110 , and anti-microbial peptides such as the defensins 111 .”
Background
- Authors
- Mesev, E. V., LeDesma, R. A., & Ploss, A.
- Affiliations
- Princeton University (US)
- Corresponding author
- Ploss, Alexander
- Venue
- Nature Microbiology
- Published
- 2019-04-01
- Volume
- 4
- Issue
- 6
- Pages
- 914-924
- ISSN
- 2058-5276 (ISSN-L)
- PMC
- PMC6554024
- OpenAlex
- W2931678155
- Cited by
- 538
- References
- 167
- Citations by year
- 2026: 54 · 2025: 65 · 2024: 85 · 2023: 89 · 2022: 81 · 2021: 104 · 2020: 49 · 2019: 11
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- U.S. Department of Defense
- American Cancer Society (RSG-15-048-01-MPC)
- New Jersey Health Foundation
- Princeton University
- National Institutes of Health
- National Institute of General Medical Sciences (T32GM007388)
- National Institute of Allergy and Infectious Diseases (R01AI138797, R01AI107301)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- type I interferon, interferon lambda, interferon signaling, antiviral defense, viral evasion, host tropism, interferon receptor, viral infection
- MeSH terms
- Interferon Lambda, Animals, Antiviral Agents, Gene Expression Regulation, Humans, Immunity, Innate, Interferon Type I, Interferons, Virus Diseases, Viruses, Signal Transduction, Tropism, Host-Pathogen Interactions, Immune Evasion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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