Cited by 538interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

Decoding type I and III interferon signalling during viral infection

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Mesev, Emily V., LeDesma, Robert A., Ploss, Alexander·2019·Nature Microbiology

Abstract

Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species.

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  • The ability to fine-tune an IFN response is critical because both overactivation and underactivation are deleterious to the host.

    “The ability to fine-tune an IFN response is critical because both its overactivation and underactivation are deleterious to the host (Mesev et al., 2019).”

    From COVID-19 and the human innate immune system (2021) · cites this paper as Mesev et al., 2019

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Authors
Mesev, E. V., LeDesma, R. A., & Ploss, A.
Affiliations
Princeton University (US)
Corresponding author
Ploss, Alexander
Venue
Nature Microbiology
Published
2019-04-01
Volume
4
Issue
6
Pages
914-924
ISSN
2058-5276 (ISSN-L)
OpenAlex
W2931678155
Cited by
538
References
167
Citations by year
2026: 54 · 2025: 65 · 2024: 85 · 2023: 89 · 2022: 81 · 2021: 104 · 2020: 49 · 2019: 11
FWCI
5.28
Type
journal article
Language
en
Open access
Locations
  • Nature Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • U.S. Department of Defense
  • American Cancer Society (RSG-15-048-01-MPC)
  • New Jersey Health Foundation
  • Princeton University
  • National Institutes of Health
  • National Institute of General Medical Sciences (T32GM007388)
  • National Institute of Allergy and Infectious Diseases (R01AI138797, R01AI107301)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
type I interferon, interferon lambda, interferon signaling, antiviral defense, viral evasion, host tropism, interferon receptor, viral infection
MeSH terms
Interferon Lambda, Animals, Antiviral Agents, Gene Expression Regulation, Humans, Immunity, Innate, Interferon Type I, Interferons, Virus Diseases, Viruses, Signal Transduction, Tropism, Host-Pathogen Interactions, Immune Evasion

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