The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health
Open accessAbstract
SUMMARY Dietary supplementation with fermentable fiber suppresses adiposity and the associated parameters of metabolic syndrome. Microbiota-generated fiber-derived short-chain fatty acids (SCFA) and free fatty acid receptors including GPR43 are thought to mediate these effects. We find that while fermentable (inulin), but not insoluble (cellulose) fiber, markedly protected mice against high-fat diet (HFD)-induced metabolic syndrome, the effect was not significantly impaired by either inhibiting SCFA production or genetic ablation of GPR43. Rather, HFD decimates gut microbiota resulting in loss of enterocyte proliferation, leading to microbiota encroachment, low-grade inflammation (LGI) and metabolic syndrome. Enriching HFD with inulin restored microbiota loads, IL-22 production, enterocyte proliferation, and anti-microbial gene expression in a microbiota dependent manner, as assessed by antibiotic and germ-free approaches. Inulin-induced IL-22 expression, which required innate lymphoid cells, prevented microbiota encroachment and protected against LGI and metabolic syndrome. Thus, fermentable fiber protects against metabolic syndrome by nourishing microbiota to restore IL-22-mediated enterocyte function.
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Cites
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Self-citationDiet-induced extinctions in the gut microbiota compound over generations
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“The staining of bacteria localization at the surface of the intestinal mucosa was conducted as previously described (Chassaing et al., 2014).”
BackgroundMethodInfluential
Cited by
The impact of dietary fiber on gut microbiota in host health and disease
Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.012 · Cited by 2,517
Role of the gut microbiota in nutrition and health
Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ · doi:10.1136/bmj.k2179 · Cited by 2,375
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792
Gut microbiota-derived metabolites as central regulators in metabolic disorders
Agus, A., Clément, K., & Sokol, H. (2021) · Gut · doi:10.1136/gutjnl-2020-323071 · Cited by 1,347
Human gut microbiota/microbiome in health and diseases: a review
Gomaa, E. Z. (2020) · Antonie van Leeuwenhoek · doi:10.1007/s10482-020-01474-7 · Cited by 1,294
Metadata
- Authors
- Zou, J., Chassaing, B., Singh, V., Pellizzon, M., Ricci, M., Fythe, M. D., Kumar, M. V., & Gewirtz, A. T.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 23
- Issue
- 1
- Pages
- 41-53.e4
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2776874704
- Cited by
- 563
- References
- 13
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zou, J., Chassaing, B., Singh, V., Pellizzon, M., Ricci, M., Fythe, M. D., Kumar, M. V., & Gewirtz, A. T. (2018). Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2017.11.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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