The impact of dietary fiber on gut microbiota in host health and disease
Open accessAbstract
Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract-the gut microbiota. Type, quality, and origin of our food shape our gut microbes and affect their composition and function, impacting host-microbe interactions. In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health. Hippocrates' notion "Let food be thy medicine and medicine be thy food" remains highly relevant millennia later, but requires consideration of how diet can be used for modulation of gut microbial ecology to promote health.
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- Authors
- Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F.
- Affiliations
- Sahlgrenska University Hospital (SE)
- University of Alberta (CA)
- University of Copenhagen (DK)
- Corresponding author
- Bäckhed, Fredrik
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 23
- Issue
- 6
- Pages
- 705-715
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2808386728
- Semantic Scholar
- 51fb1e372be71d2db7e78059921dbed50d69bc88
- Cited by
- 2,517
- References
- 97
- Citations by year
- 2026: 326 · 2025: 376 · 2024: 357 · 2023: 334 · 2022: 385 · 2021: 345 · 2020: 255 · 2019: 118 · 2018: 18 · 2017: 1
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- European Research Council (615362 - METABASE)
- Diabetesförbundet
- Fondation Leducq
- Novo Nordisk Fonden
- Hjärt-Lungfonden
- Knut och Alice Wallenbergs Stiftelse
- Canadian Institutes of Health Research
- Sahlgrenska Universitetssjukhuset
- Västra Götalandsregionen
- Göran Gustafssons Stiftelser
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- dietary fiber, gut microbiota, short-chain fatty acids, host-microbe interactions, diet and health, gut microbiota metabolites
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Diabetes Mellitus, Type 2, Diet, Dietary Fiber, Ecology, Fatty Acids, Volatile, Humans, Obesity, Food Chain, Gastrointestinal Tract, Microbiota
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