Cited by 2,517Gut microbiota and healthFood composition and propertiesMicrobial Metabolites in Food Biotechnology

The impact of dietary fiber on gut microbiota in host health and disease

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Makki, Kassem, Deehan, Edward C., Walter, Jens, Bäckhed, Fredrik·2018·Cell Host & Microbe

Abstract

Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract-the gut microbiota. Type, quality, and origin of our food shape our gut microbes and affect their composition and function, impacting host-microbe interactions. In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health. Hippocrates' notion "Let food be thy medicine and medicine be thy food" remains highly relevant millennia later, but requires consideration of how diet can be used for modulation of gut microbial ecology to promote health.

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Crossref · 10.1016/j.chom.2018.05.012

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Authors
Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F.
Affiliations
  • Sahlgrenska University Hospital (SE)
  • University of Alberta (CA)
  • University of Copenhagen (DK)
Corresponding author
Bäckhed, Fredrik
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2018-06
Volume
23
Issue
6
Pages
705-715
ISSN
1931-3128 (ISSN-L)
OpenAlex
W2808386728
Cited by
2,517
References
97
Citations by year
2026: 326 · 2025: 376 · 2024: 357 · 2023: 334 · 2022: 385 · 2021: 345 · 2020: 255 · 2019: 118 · 2018: 18 · 2017: 1
FWCI
18.07
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • European Research Council (615362 - METABASE)
  • Diabetesförbundet
  • Fondation Leducq
  • Novo Nordisk Fonden
  • Hjärt-Lungfonden
  • Knut och Alice Wallenbergs Stiftelse
  • Canadian Institutes of Health Research
  • Sahlgrenska Universitetssjukhuset
  • Västra Götalandsregionen
  • Göran Gustafssons Stiftelser
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
dietary fiber, gut microbiota, short-chain fatty acids, host-microbe interactions, diet and health, gut microbiota metabolites
MeSH terms
Gastrointestinal Microbiome, Bacteria, Diabetes Mellitus, Type 2, Diet, Dietary Fiber, Ecology, Fatty Acids, Volatile, Humans, Obesity, Food Chain, Gastrointestinal Tract, Microbiota

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