Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232 · see citing works

Effect of fatty acids on glucose production and utilization in man.

Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050 · see citing works

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 919 · see citing works

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.015 · Cited by 804 · see citing works

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737 · see citing works

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

Randle, P., Newsholme, E., & Garland, P. (1964) · Biochemical Journal · doi:10.1042/bj0930652 · Cited by 736 · see citing works

Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach

Zeisberger, S. M., Odermatt, B., Marty, C., Zehnder-Fjällman, A. H. M., Ballmer‐Hofer, K., & Schwendener, R. A. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603240 · Cited by 622 · see citing works

JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity

Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513 · see citing works

Regulation of Glucose Uptake by Muscle

Randle, P. J., & Morgan, H. E. (1962) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60718-9 · Cited by 502 · see citing works

PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works

Muscle-specific Pparg deletion causes insulin resistance

Hevener, A. L., He, W., Barak, Y., Le, J., Bandyopadhyay, G. K., Olson, P., Wilkes, J. J., Evans, R. M., & Olefsky, J. M. (2003) · Nature Medicine · doi:10.1038/nm956 · Cited by 492 · see citing works

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

Saberi, M., Woods, N.-B., de Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., Verma, I. M., & Olefsky, J. M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.006 · Cited by 456 · see citing works

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

Li, P., Lu, M. M., Nguyen, M. T., Bae, E. J., Chapman, J., Feng, D., Hawkins, M. A., Pessin, J. E., Sears, D. D., Nguyen, A.-K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100263 · Cited by 240 · see citing works

Dysregulation of Adipose Glutathione Peroxidase 3 in Obesity Contributes to Local and Systemic Oxidative Stress

Lee, Y. S., Kim, A., Choi, J. W., Kim, M., Yasue, S., Son, H. J., Masuzaki, H., Park, K. S., & Kim, J. B. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0023 · Cited by 184 · see citing works

Adipocytokine Orosomucoid Integrates Inflammatory and Metabolic Signals to Preserve Energy Homeostasis by Resolving Immoderate Inflammation

Lee, Y. S., Choi, J. W., Hwang, I., Lee, J. W., Lee, J. H., Kim, A. Y., Huh, J. Y., Koh, Y. J., Koh, G. Y., Son, H. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085464 · Cited by 131 · see citing works

Adipose tissue lipolysis

Kolditz, C.-I., & Langin, D. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833bed6a · Cited by 116 · see citing works

Effect of reproductive states on lipid mobilization and linoleic acid metabolism in mammary glands

Bandyopadhyay, G. K., Lee, L. P., Guzman, R. C., & Nandi, S. (1995) · Lipids · doi:10.1007/bf02538269 · Cited by 26 · see citing works

Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling

Frangioudakis, G., & Cooney, G. J. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0623 · Cited by 24 · see citing works

Adipose tissue inflammation and metabolic dysfunction in obesity

Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947 · see citing works

Insulin action and resistance in obesity and type 2 diabetes

Czech, M. P. (2017) · Nature Medicine · doi:10.1038/nm.4350 · Cited by 1,258 · see citing works

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206 · see citing works

Metabolic Inflammation and Insulin Resistance in Obesity

Wu, H., & Ballantyne, C. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315896 · Cited by 1,059 · see citing works

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works

Skeletal muscle inflammation and insulin resistance in obesity

Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695 · see citing works

The aetiology and molecular landscape of insulin resistance

James, D. E., Stöckli, J., & Birnbaum, M. J. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00390-6 · Cited by 701 · see citing works

Regulation of metabolism by the innate immune system

Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667 · see citing works

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

Kahn, C. R., Wang, G., & Lee, K. Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129187 · Cited by 656 · see citing works

The Origins and Drivers of Insulin Resistance

Johnson, A. M. F., & Olefsky, J. M. (2013) · Cell · doi:10.1016/j.cell.2013.01.041 · Cited by 639 · see citing works

Adipokine dysregulation and adipose tissue inflammation in human obesity

Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610 · see citing works

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.012 · Cited by 598 · see citing works

What causes the insulin resistance underlying obesity?

Hardy, O. T., Czech, M. P., & Corvera, S. (2012) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283514e13 · Cited by 563 · see citing works

Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health

Zou, J., Chassaing, B., Singh, V., Pellizzon, M., Ricci, M. R., Flythe, M. D. D., Kumar, M. V., & Gewirtz, A. T. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.11.003 · Cited by 564 · see citing works

Inflammatory Links Between High Fat Diets and Diseases

Duan, Y., Zeng, L., Zheng, C., Song, B., Li, F., Kong, X., & Xu, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02649 · Cited by 495 · see citing works

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Pan, Y., Hui, X. H., Hoo, R. L. C., Ye, D., Chan, C. Y. C., Feng, T., Wang, Y., Lam, K. S. L., & Xu, A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123069 · Cited by 497 · see citing works

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz-Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 502 · see citing works

Insulin resistance causes inflammation in adipose tissue

Shimobayashi, M., Albert, V., Woelnerhanssen, B., Frei, I. C., Weissenberger, D., Meyer-Gerspach, A. C., Clement, N., Moes, S., Colombi, M., Meier, J. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96139 · Cited by 480 · see citing works

Adipocyte lipolysis and insulin resistance

Morigny, P., Houssier, M., Mouisel, É., & Langin, D. (2015) · Biochimie · doi:10.1016/j.biochi.2015.10.024 · Cited by 471 · see citing works

An Integrated View of Immunometabolism

Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 440 · see citing works

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430 · see citing works

Adipose tissue macrophages: going off track during obesity

Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 430 · see citing works

Adaptive immunity in obesity and insulin resistance

Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486 · see citing works

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

Huh, J. Y., Park, Y. J., Ham, M., & Kim, J. B. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0074 · Cited by 416 · see citing works

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

Montgomery, M. K., Hallahan, N., Brown, S. H. J., Liu, M., Mitchell, T. W., Cooney, G. J., & Turner, N. A. (2013) · Diabetologia · doi:10.1007/s00125-013-2846-8 · Cited by 416 · see citing works

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 427 · see citing works

Macrophage polarization and meta-inflammation

Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 369 · see citing works

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343 · see citing works

Chronic tissue inflammation and metabolic diseasePreprint

Lee, Y. S., & Olefsky, J. M. (2021) · Genes & Development · doi:10.1101/gad.346312.120 · Cited by 342 · see citing works

Obesity phenotypes and their paradoxical association with cardiovascular diseases

Vecchié, A., Dallegri, F., Carbone, F., Bonaventura, A., Liberale, L., Portincasa, P., Frühbeck, G., & Montecucco, F. (2017) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2017.10.020 · Cited by 332 · see citing works

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 318 · see citing works

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

Sun, S., Ji, Y., Kersten, S., & Qi, L. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150623 · Cited by 305 · see citing works

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

van der Heijden, R. A., Sheedfar, F., Morrison, M. C., Hommelberg, P. P. H., Kor, D., Kloosterhuis, N., Gruben, N., Youssef, S. A., de Bruin, A., Hofker, M. H., et al. (2015) · Aging · doi:10.18632/aging.100738 · Cited by 288 · see citing works

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Pillon, N. J., Bilan, P. J., Fink, L. N., & Klip, A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2012 · Cited by 285 · see citing works

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

Yung, J. H. M., & Giacca, A. (2020) · Cells · doi:10.3390/cells9030706 · Cited by 267 · see citing works

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

Kim, J. I., Huh, J. Y., Sohn, J. H., Choe, S. S., Lee, Y. S., Lim, C. Y., Jo, A., Park, S. B., Han, W., & Kim, J. B. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01321-14 · Cited by 258 · see citing works

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

Jaïs, A., Solas, M., Backes, H., Chaurasia, B., Kleinridders, A., Theurich, S., Mauer, J., Steculorum, S. M., Hampel, B., Goldau, J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.033 · Cited by 253 · see citing works

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

Tai, N., Wong, F. S., & Li, W. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-015-9309-0 · Cited by 254 · see citing works

Mechanisms of insulin resistance related to white, beige, and brown adipocytes

Czech, M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.014 · Cited by 245 · see citing works

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

Pinkosky, S. L., Filippov, S. I., Srivastava, R. A. K., Hanselman, J. C., Bradshaw, C. D., Hurley, T. R., Cramer, C. T., Spahr, M. A., Brant, A. F., Houghton, J. L., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m030528 · Cited by 240 · see citing works

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Xia, C. Q., Rao, X., & Zhong, J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/6494795 · Cited by 240 · see citing works

Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance

Kim, A. Y., Park, Y. J., Pan, X., Shin, K. C., Kwak, S., Bassas, A. F., Sallam, R. M., Park, K. S., Alfadda, A. A., Xu, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8585 · Cited by 235 · see citing works

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

Neuhofer, A., Zeyda, M., Mascher, D. G., Itariu, B. K., Murano, I., Leitner, L., Hochbrugger, E., Fraisl, P., Cinti, S., Serhan, C. N., et al. (2013) · Diabetes · doi:10.2337/db12-0828 · Cited by 232 · see citing works

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

Westwell-Roper, C. Y., Ehses, J. A., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db13-0863 · Cited by 225 · see citing works

Warming the mouse to model human diseases

Ganeshan, K., & Chawla, A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.48 · Cited by 219 · see citing works

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214 · see citing works

Short‐ or long‐term high‐fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

Chang, B., Xu, M., Zhou, Z., Cai, Y., Li, M., Wang, W., Feng, D., Bertola, A., Wang, H., Kunos, G., et al. (2015) · Hepatology · doi:10.1002/hep.27921 · Cited by 212 · see citing works

Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon‐like peptide 1 in diet‐induced obesity

Hwang, I., Park, Y. J., Kim, Y.-R., Kim, Y. N., Ka, S., Lee, H., Seong, J. K., Seok, Y., & Kim, J. B. (2015) · The FASEB Journal · doi:10.1096/fj.14-265983 · Cited by 206 · see citing works

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

Xie, C., Jiang, C., Shi, J., Gao, X., Sun, D., Sun, L., Wang, T., Takahashi, S., Anitha, M., Krausz, K. W., et al. (2016) · Diabetes · doi:10.2337/db16-0663 · Cited by 201 · see citing works

Interaction between gut microbiota and toll-like receptor: from immunity to metabolism

Yiu, J. H. C., Dorweiler, B., & Woo, C. W. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1474-4 · Cited by 200 · see citing works

Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans

Fink, L. N., Costford, S. R., Lee, Y. S., Jensen, T. E., Bilan, P. J., Oberbach, A., Blüher, M., Olefsky, J. M., Sams, A. G., & Klip, A. (2013) · Obesity · doi:10.1002/oby.20615 · Cited by 199 · see citing works

The initiation of metabolic inflammation in childhood obesity

Singer, K., & Lumeng, C. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88882 · Cited by 194 · see citing works

Fatty acid metabolism, energy expenditure and insulin resistance in muscle.

Turner, N., Cooney, G., Kraegen, E., & Bruce, C. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0397 · Cited by 203 · see citing works

Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family

Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 192 · see citing works

Muscle and adipose tissue insulin resistance: malady without mechanism?

Fazakerley, D. J., Krycer, J. R., Kearney, A. L., HOCKING, S. L., & James, D. E. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r087510 · Cited by 181 · see citing works

The Development of Diet-Induced Obesity and Glucose Intolerance in C57Bl/6 Mice on a High-Fat Diet Consists of Distinct Phases

Williams, L. M., Campbell, F., Drew, J. E., Koch, C. E., Hoggard, N., Rees, W. D., Kamolrat, T., Ngo, H. T., Steffensen, I., Gray, S. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106159 · Cited by 176 · see citing works

The Interplay Among Oxidative Stress, Brain Insulin Resistance and AMPK Dysfunction Contribute to Neurodegeneration in Type 2 Diabetes and Alzheimer Disease

Barone, E., Domenico, F. D., Perluigi, M., & Butterfield, D. (2021) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 155 · see citing works

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice

Mosser, R. E., Maulis, M. F., Moullé, V. S. F., Dunn, J. C., Carboneau, L., Arasi, K., Pappan, K. L., Poitout, V., & GANNON, M. A. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00460.2014 · Cited by 170 · see citing works

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

Negrin, K. A., Flach, R. J. R., DiStefano, M. T., Matevossian, A., Friedline, R. H., Jung, D., Kim, J. K., & Czech, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107265 · Cited by 166 · see citing works

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

Kowalski, G. M., & Bruce, C. R. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00165.2014 · Cited by 154 · see citing works

Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue

Han, C. Y. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.4.272 · Cited by 159 · see citing works

Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota

Li, X., Guo, J., Ji, K., & Zhang, P. (2016) · Scientific Reports · doi:10.1038/srep32953 · Cited by 160 · see citing works

Lymphocytes in obesity-related adipose tissue inflammation

Chatzigeorgiou, A., Karalis, K. P., Bornstein, S. R., & Chavakis, T. (2012) · Diabetologia · doi:10.1007/s00125-012-2607-0 · Cited by 157 · see citing works

Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes

Kohlgruber, A. C., & Lynch, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0670-x · Cited by 156 · see citing works

Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB

Tourniaire, F., Romier, B., Lee, J. H., Marcotorchino, J., Gouranton, E., Salles, J., Malezet‐Desmoulins, C., Astier, J., Darmon, P., Blouin, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066515 · Cited by 152 · see citing works

Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance

Tian, X. Y., Ganeshan, K., Hong, C., Nguyen, K. D., Qiu, Y., Kim, J., Tangirala, R. K., Tontonoz, P., & Chawla, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.003 · Cited by 149 · see citing works

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150 · see citing works

The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion

Lee, Y. S., Morinaga, H., Kim, J. J., Lagakos, W., Taylor, S., Keshwani, M., Perkins, G., Dong, H., Kayali, A. G., Sweet, I. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.001 · Cited by 141 · see citing works

A major role of insulin in promoting obesity-associated adipose tissue inflammation

Pedersen, D. J., Guilherme, A., Danai, L. V., Heyda, L. M., Matevossian, A., Cohen, J. L., Nicoloro, S. M. C., Straubhaar, J., Noh, H. L., Jung, D.-Y., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.003 · Cited by 141 · see citing works

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression

Stamateris, R. E., Sharma, R. B., Hollern, D. A., & Alonso, L. C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00040.2013 · Cited by 138 · see citing works

The metabolic role of vagal afferent innervation

Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0062-1 · Cited by 140 · see citing works

One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice

Waise, T. M. Z., Toshinai, K., Naznin, F., NamKoong, C., Moin, A. S. M., Sakoda, H., & Nakazato, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.097 · Cited by 134 · see citing works

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

Püschel, G. P., Klauder, J., & Henkel, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154358 · Cited by 139 · see citing works

Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health

Melo, H. M., Santos, L. E., & Ferreira, S. T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00265 · Cited by 136 · see citing works

A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats

Lindholm, C. R., Ertel, R. L., Bauwens, J. D., Schmuck, E. G., Mulligan, J. D., & Saupe, K. W. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0199-2 · Cited by 136 · see citing works

MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue

Sun, X., Lin, J., Zhang, Y., Kang, S., Belkin, N., Wara, A. K., Icli, B., Hamburg, N. M., Li, D., & Feinberg, M. W. (2016) · Circulation Research · doi:10.1161/circresaha.115.308166 · Cited by 133 · see citing works

STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice

Zhu, M., Peng, L., Huo, S., Peng, D., Gou, J., Shi, W., Tao, J., Jiang, T., Jiang, Y., Wang, Q., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.003 · Cited by 137 · see citing works

Salidroside Attenuates High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease via AMPK‐Dependent TXNIP/NLRP3 Pathway

Zheng, T., Yang, X., Li, W., Wang, Q., Chen, L., Wu, D., Bian, F., Xing, S., & Jin, S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8597897 · Cited by 135 · see citing works

A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells

Huh, J. Y., Kim, J. I., Park, Y. J., Hwang, I., Lee, Y. S., Sohn, J. H., Lee, S. K., Alfadda, A. A., Kim, S. S., Choi, S. H., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00552-12 · Cited by 130 · see citing works

Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate‐containing diet in mice

Oliveira, M. C., Garcia, Z. M., Henriques, M. C., Soriani, F. M., Pinho, V., Faria, A. M. C., Santiago, A. F., Cara, D. C., Souza, D. G., Teixeira, M. M., et al. (2013) · Obesity · doi:10.1002/oby.20230 · Cited by 126 · see citing works

Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters

Enos, R. T., Davis, J. M., Velázquez, K. T., McClellan, J. L., Day, S. D., Carnevale, K. A., & Murphy, E. A. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m030700 · Cited by 126 · see citing works

Is obesity a brain disease?

Shefer, G., Marcus, Y., & Stern, N. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.015 · Cited by 124 · see citing works

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

Sasaki, A., Nagatake, T., Egami, R., Gu, G., Takigawa, I., Ikeda, W., Nakatani, T., Kunisawa, J., & Fujita, Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.104 · Cited by 125 · see citing works

Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders

Ghasemi, R., Dargahi, L., Haeri, A., Moosavi, M., Mohamed, Z., & Ahmadiani, A. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8404-z · Cited by 121 · see citing works

Animal models of insulin resistance: A review

Sah, S. P., Singh, B., Choudhary, S., & Kumar, A. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.07.010 · Cited by 117 · see citing works

Inhibition of Soluble Epoxide Hydrolase Attenuates High-Fat-Diet–Induced Hepatic Steatosis by Reduced Systemic Inflammatory Status in Mice

Liu, Y., Dang, H., Li, D., Pang, W., Hammock, B. D., & Zhu, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039165 · Cited by 114 · see citing works

Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity

Seo, J. B., Riopel, M., Cabrales, P., Huh, J. Y., Bandyopadhyay, G. K., Andreyev, A. Y., Murphy, A. N., Beeman, S. C., Smith, G. I., Klein, S., et al. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0003-x · Cited by 113 · see citing works

SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

Lee, G., Kim, Y. Y., Jang, H., Han, J. S., Nahmgoong, H., Park, Y. J., Han, S. M., Cho, C., Lim, S., Noh, J.-R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.010 · Cited by 111 · see citing works

Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

Banerjee, A., Mukherjee, S., & Maji, B. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.04.009 · Cited by 103 · see citing works

Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity

Sakamoto, K., Butera, M. A., Zhou, C., Maurizi, G., Chen, B., Li, L., Shawkat, A., Patlolla, L., Thakker, K., Calle, V. L., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.012 · Cited by 119 · see citing works

Immune cells in adipose tissue: Key players in metabolic disorders

Lolmède, K., Duffaut, C., Zakaroff‐Girard, A., & Bouloumié, A. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2011.03.002 · Cited by 110 · see citing works

Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats

Bai, J., Zhu, Y. G., & Dong, Y. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.10.043 · Cited by 110 · see citing works

Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

Sharma, M., Boytard, L., Hadi, T., Koelwyn, G. J., Simon, R., Ouimet, M. I., Seifert, L., Spiro, W., Yan, B., Hutchison, S. B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62272-9 · Cited by 105 · see citing works

In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice

Paglialunga, S., Ludzki, A. C., Root-McCaig, J., & Holloway, G. P. (2015) · Diabetologia · doi:10.1007/s00125-015-3531-x · Cited by 104 · see citing works

Are Obesity-Related Insulin Resistance and Type 2 Diabetes Autoimmune Diseases?

Tsai, S., Clemente-Casares, X., Revelo, X. S., Winer, S., & Winer, D. (2015) · Diabetes · doi:10.2337/db14-1488 · Cited by 90 · see citing works

Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue

Eringa, E. C., Bakker, W., & van Hinsbergh, V. W. M. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.003 · Cited by 103 · see citing works

A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption

Jang, H. R., Park, H., Kang, D., Chung, H., Nam, M. H., Lee, Y., Park, J., & Lee, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0293-4 · Cited by 102 · see citing works

Rutin increases muscle mitochondrial biogenesis with AMPK activation in high-fat diet-induced obese rats.

Seo, S., Lee, M.-S., Chang, E., Shin, Y., Oh, S., Kim, I.-H., & Kim, Y. (2015) · Nutrients · doi:10.3390/nu7095385 · Cited by 100 · see citing works

Insulin Resistance in the Defense against Obesity

Saltiel, A. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.001 · Cited by 101 · see citing works

Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes

Kuryłowicz, A., & Koźniewski, K. (2020) · Molecules · doi:10.3390/molecules25092224 · Cited by 101 · see citing works

Characterization of inflammation and insulin resistance in high‐fat diet‐induced male C57BL/6J mouse model of obesity

Avtanski, D. B., Pavlov, V. A., Tracey, K. J., & Poretsky, L. (2019) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12084 · Cited by 108 · see citing works

The pathogenic role of macrophage migration inhibitory factor in high-fat diet induced insulin resistance

Finucane, O. M. (2012) · Arrow@dit (Dublin Institute of Technology)

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430 · see citing works

High fat diet‐induced muscle insulin resistance: role of cytokines and local macrophages

Vandanmagsar, B., Bermudez, E., Ravussin, É., & Mynatt, R. L. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.364.5