The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV
Open accessAbstract
Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and treatment is lifelong. HIV persists during ART due to long lived and proliferating latently infected CD4+ T-cells. One strategy to eliminate latency is to activate virus production using latency reversing agents (LRAs) with the goal of triggering cell death through virus-induced cytolysis or immune-mediated clearance. However, multiple studies have demonstrated that activation of viral transcription alone is insufficient to induce cell death and some LRAs may counteract cell death by promoting cell survival. Here, we review new approaches to induce death of latently infected cells through apoptosis and inhibition of pathways critical for cell survival, which are often hijacked by HIV proteins. Given advances in the commercial development of compounds that induce apoptosis in cancer chemotherapy, these agents could move rapidly into clinical trials, either alone or in combination with LRAs, to eliminate latent HIV infection.
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1 retracted
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Cited by
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Deeks, S. G., Archin, N., Cannon, P., Collins, S., Jones, R. B., de Jong, M. A. W. P., Lambotte, O., Lamplough, R., Ndung’u, T., Sugarman, J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01590-5 · Cited by 377
Self-citationTargeting the Latent Reservoir for HIV-1
Sengupta, S., & Siliciano, R. F. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.030 · Cited by 340
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies
Cohn, L. B., Chomont, N., & Deeks, S. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.014 · Cited by 284
Ait-Ammar, A., Kula, A., Darcis, G., Verdikt, R., De Wit, S., Gautier, V., Mallon, P. W. G., Marcello, A., Rohr, O., & Van Lint, C. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03060 · Cited by 163
HIV Reservoirs and Treatment Strategies toward Curing HIV Infection
Matsuda, K., & Maeda, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052621 · Cited by 43
Metadata
- Authors
- Kim, Y., Anderson, J. L., & Lewin, S. R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 23
- Issue
- 1
- Pages
- 14-26
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2782696110
- Cited by
- 414
- References
- 126
- FWCI
- 22.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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