The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies
Open accessAbstract
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells. Here, we describe the mechanisms thought to contribute to its persistence during treatment and highlight findings from numerous recent studies describing the importance of cell proliferation in that process. Continued progress elucidating the biology will enhance our ability to develop effective curative interventions.
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Citations
Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Self-citationIdentification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
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Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Chomont, N., El-Far, M., Ancuta, P., Trautmann, L., Procopio, F. A., Yassine-Diab, B., Boucher, G., Boulassel, M.-R., Ghattas, G., Brenchley, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1972 · Cited by 1,722
Self-citationReplication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Ho, Y.-C., Shan, L., Hosmane, N. N., Wang, J., Laskey, S. B., Rosenbloom, D. I. S., Lai, J., Blankson, J. N., Siliciano, J. D., & Siliciano, R. F. (2013) · Cell · doi:10.1016/j.cell.2013.09.020 · Cited by 1,405
Sáez-Cirión, A., Bacchus, C., Hocqueloux, L., Avettand-Fenoel, V., Girault, I., Lecuroux, C., Potard, V., Versmisse, P., Melard, A., Prazuck, T., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003211 · Cited by 1,011
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Maldarelli, F., Wu, X., Su, L., Simonetti, F. R., Shao, W., Hill, S., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., et al. (2014) · Science · doi:10.1126/science.1254194 · Cited by 849
Defective proviruses rapidly accumulate during acute HIV-1 infection
Bruner, K. M., Murray, A. J., Pollack, R. A., Soliman, M. G., Laskey, S. B., Capoferri, A. A., Lai, J., Strain, M. C., Lada, S. M., Hoh, R., et al. (2016) · Nature Medicine · doi:10.1038/nm.4156 · Cited by 737
Self-citation
Cited by
HIV Reservoirs and Treatment Strategies toward Curing HIV Infection
Matsuda, K., & Maeda, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052621 · Cited by 43
Metadata
- Authors
- Cohn, L. B., Chomont, N., & Deeks, S. G.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 27
- Issue
- 4
- Pages
- 519-530
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W3015484735
- Cited by
- 284
- References
- 133
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cohn, L. B., Chomont, N., & Deeks, S. G. (2020). The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2020.03.014
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
