The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development
Open accessAbstract
Symbionts play an indispensable role in gut homeostasis, but underlying mechanisms remain elusive. To clarify the role of lactic-acid-producing bacteria (LAB) on intestinal stem-cell (ISC)-mediated epithelial development, we fed mice with LAB-type symbionts such as Bifidobacterium and Lactobacillus spp. Here we show that administration of LAB-type symbionts significantly increased expansion of ISCs, Paneth cells, and goblet cells. Lactate stimulated ISC proliferation through Wnt/β-catenin signals of Paneth cells and intestinal stromal cells. Moreover, Lactobacillus plantarum strains lacking lactate dehydrogenase activity, which are deficient in lactate production, elicited less ISC proliferation. Pre-treatment with LAB-type symbionts or lactate protected mice in response to gut injury provoked by combined treatments with radiation and a chemotherapy drug. Impaired ISC-mediated epithelial development was found in mice deficient of the lactate G-protein-coupled receptor, Gpr81. Our results demonstrate that LAB-type symbiont-derived lactate plays a pivotal role in promoting ISC-mediated epithelial development in a Gpr81-dependent manner.
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Cites
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Cited by
Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine
Kayama, H., Okumura, R., & Takeda, K. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115104 · Cited by 747
Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions
Nicolas, G. R., & Chang, P. V. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.04.006 · Cited by 195
Tumor microbiome links cellular programs and immunity in pancreatic cancer
Ghaddar, B., Biswas, A., Harris, C., Omary, M. B., Carpizo, D. R., Blaser, M. J., & De, S. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.09.009 · Cited by 181
Ioannou, A., Knol, J., & Belzer, C. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.631282 · Cited by 44
Heinzel, S., Jureczek, J., Kainulainen, V., Nieminen, A. I., Suenkel, U., von Thaler, A.-K., Kaleta, C., Eschweiler, G. W., Brockmann, K., Aho, V. T. E., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-63893-0 · Cited by 36
Metadata
- Authors
- Lee, Y.-S., Kim, T.-Y., Kim, Y., Lee, S.-H., Kim, S., Kang, S. W., Yang, J.-Y., Baek, I.-J., Sung, Y. H., Park, Y.-Y., Hwang, S. W., O, E., Kim, K. S., Liu, S., Kamada, N., Gao, N., & Kweon, M.-N.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 24
- Issue
- 6
- Pages
- 833-846.e6
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2903916121
- Cited by
- 459
- References
- 64
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, Y.-S., Kim, T.-Y., Kim, Y., Lee, S.-H., Kim, S., Kang, S. W., Yang, J.-Y., Baek, I.-J., Sung, Y. H., Park, Y.-Y., Hwang, S. W., O, E., Kim, K. S., Liu, S., Kamada, N., Gao, N., & Kweon, M.-N. (2018). Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2018.11.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
