Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions
Open accessAbstract
The human intestine harbors an immense, diverse, and critical population of bacteria that has effects on numerous aspects of host physiology, immunity, and disease. Emerging evidence suggests that many of the interactions between the host and the gut microbiota are mediated via the microbial metabolome, or the collection of small-molecule metabolites produced by intestinal bacteria. This review summarizes findings from recent work by focusing on different classes of metabolites produced by the gut microbiota and their effects in modulating host health and disease. These metabolites ultimately serve as a form of communication between the gut microbiome and the host, and a better understanding of this chemical language could potentially lead to novel strategies for treating a wide variety of human disorders.
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Gut microbiota and microbial metabolites influence many aspects of host physiology.
“Gut microbiota and microbial metabolites influence many aspects of host physiology35.”
From Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer (2021) · cites this paper as [35]
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Luu, M., Riester, Z., Baldrich, A., Reichardt, N., Yuille, S., Busetti, A., Klein, M., Wempe, A., Leister, H., Raifer, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24331-1 · Cited by 771 · see citing works
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor
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Self-citation
- Authors
- Nicolas, G. R., & Chang, P. V.
- Affiliations
- Cornell University (US)
- Corresponding author
- Chang, Pamela V.
- ORCID
- Chang, Pamela V.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 40
- Issue
- 6
- Pages
- 430-445
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC6681900
- OpenAlex
- W2944790464
- Cited by
- 195
- References
- 88
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 42 · 2023: 27 · 2022: 20 · 2021: 23 · 2020: 17 · 2019: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T32GM008500)
- Arnold and Mabel Beckman Young Investigator Award
- President’s Council of Cornell Women Affinito-Stewart Grant
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, host-microbe interactions, microbial metabolome, microbial metabolites, intestinal bacteria, host health, host disease
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Humans, Immune System, Gastrointestinal Tract, Host-Pathogen Interactions, Metabolome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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