The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
Open accessAbstract
Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, in medicine, and in industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.
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Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · cited 2×
“Visualization of individual bacterial cells established that, prior to antibiotic treatment, an exponentially growing bacterial population contains a pre-existing fraction of non-growing cells (Balaban et al., 2004).”
BackgroundMetabolite-enabled eradication of bacterial persisters by aminoglycosides
Allison, K. R., Brynildsen, M. P., & Collins, J. J. (2011) · Nature · doi:10.1038/nature10069 · Cited by 1,025
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
Kaplan, J. B. (2010) · Journal of Dental Research · doi:10.1177/0022034509359403 · Cited by 949
Cited by
Imaging biofilms using fluorescence in situ hybridization: seeing is believing
Barbosa, A., Miranda, S., Azevedo, N. F., Cerqueira, L., & Azevedo, A. S. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1195803 · Cited by 63
Arunachalam, K., Pandurangan, P., Shi, C., & Lagoa, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020310 · Cited by 48
Impact of bacterial persisters on their host
Moldoveanu, A. L., Rycroft, J. A., & Helaine, S. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.07.006 · Cited by 44
Zeineldin, M., Esmael, A., Al-Hindi, R. R., Alharbi, M. G., Ashenafi Bekele, D., & Teklemariam, A. D. (2023) · Life · doi:10.3390/life13020503 · Cited by 27
Zhang, J., Wang, Y., Donarski, E. D., Toma, T. T., Miles, M. T., Acton, S. T., & Gahlmann, A. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00362-4 · Cited by 22
Acharya, P., Lloyd, C., Lam, N. T., Kumke, J., Ray, S., Yanira Muñoz Ramirez, Z., Das, S., & Lam, H. N. (2026) · mSphere · doi:10.1128/msphere.00870-25 · Cited by 8
Ouyang, L., Xu, Z., Tang, Y., Li, D., Yu, Z., Wen, Z., Zhang, H., & Zhang, C. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03836-5 · Cited by 5
Metadata
- Authors
- Yan, J., & Bassler, B. L.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 26
- Issue
- 1
- Pages
- 15-21
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2958590276
- Cited by
- 747
- References
- 3
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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