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Cited by 48Antimicrobial Resistance in StaphylococcusNanoparticles: synthesis and applicationsBacterial biofilms and quorum sensing

Regulation of Staphylococcus aureus Virulence and Application of Nanotherapeutics to Eradicate S. aureus Infection

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Arunachalam, Kannappan, Pandurangan, Poonguzhali, Shi, Chunlei, Lagoa, Ricardo·2023·Pharmaceutics
DOI 10.3390/pharmaceutics15020310PMC PMC9960757
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Abstract

Staphylococcus aureus is a versatile pathogen known to cause hospital- and community-acquired, foodborne, and zoonotic infections. The clinical infections by S. aureus cause an increase in morbidity and mortality rates and treatment costs, aggravated by the emergence of drug-resistant strains. As a multi-faceted pathogen, it is imperative to consolidate the knowledge on its pathogenesis, including the mechanisms of virulence regulation, development of antimicrobial resistance, and biofilm formation, to make it amenable to different treatment strategies. Nanomaterials provide a suitable platform to address this challenge, with the potential to control intracellular parasitism and multidrug resistance where conventional therapies show limited efficacy. In a nutshell, the first part of this review focuses on the impact of S. aureus on human health and the role of virulence factors and biofilms during pathogenesis. The second part discusses the large diversity of nanoparticles and their applications in controlling S. aureus infections, including combination with antibiotics and phytochemicals and the incorporation of antimicrobial coatings for biomaterials. Finally, the limitations and prospects using nanomaterials are highlighted, aiming to foster the development of novel nanotechnology-driven therapies against multidrug-resistant S. aureus.

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Authors
Arunachalam, K., Pandurangan, P., Shi, C., & Lagoa, R.
Affiliations
  • MOST-USDA Joint Research Center for Food Safety, Department of Food Science and Technology, School of Agriculture and Biology, and State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Minhang, Shanghai 200240, China
  • Department of Microbiology, M.R. Government Arts College, Mannargudi, Coimbatore 614001, Tamil Nadu, India
  • United States Department of Agriculture (US)
  • Universidade de Leiria e Oeste (PT)
Corresponding author
  • Shi, Chunlei
  • Lagoa, Ricardo
ORCID
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2023-01-17
Volume
15
Issue
2
Pages
310
ISSN
1999-4923 (ISSN-L)
DOI
10.3390/pharmaceutics15020310
PMC
PMC9960757
OpenAlex
W4317036207
Cited by
48
References
9
Citations by year
2026: 12 · 2025: 15 · 2024: 17 · 2023: 4
FWCI
2.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Science and Technology Commission of Shanghai Municipality of China (21N31900200, 32001798, 31972169, UIDP/04378/2020, UIDB/04378/2020)
  • Natural Science Foundation of China (21N31900200, 32001798, 31972169, UIDP/04378/2020, UIDB/04378/2020)
  • FCT-Foundation for Science and Technology (21N31900200, 32001798, 31972169, UIDP/04378/2020, UIDB/04378/2020)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
Staphylococcus aureus, virulence regulation, virulence factors, biofilm formation, multidrug resistance, nanotherapeutics, nanoparticles, antimicrobial resistance, phytochemicals, antimicrobial coatings, biomaterials, combination therapy, intracellular parasitism, drug-resistant infections

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