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Cited by 451

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

Open access
Thingholm, Louise B., Rühlemann, Malte C., Koch, Manja, Fuqua, Brie, Laucke, Guido, Boehm, Ruwen, Bang, Corinna, Franzosa, Eric A., Hübenthal, Matthias, Rahnavard, Ali, Frost, Fabian, Lloyd-Price, Jason, Schirmer, Melanie, Lusis, Aldons J., Vulpe, Chris D., Lerch, Markus M., Homuth, Georg, Kacprowski, Tim, Schmidt, Carsten O., Nöthlings, Ute, Karlsen, Tom H., Lieb, Wolfgang, Laudes, Matthias, Franke, Andre, Huttenhower, Curtis·2019·Cell Host & Microbe
DOI 10.1016/j.chom.2019.07.004
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Abstract

SUMMARY Obesity and type 2 diabetes (T2D) are metabolic disorders that are linked to microbiome alterations. However, their co-occurrence poses challenges in disentangling microbial features unique to each condition. We analyzed gut microbiomes of lean non-diabetic (n = 633), obese non-diabetic (n = 494), and obese individuals with T2D (n = 153) from German population and metabolic disease cohorts. Microbial taxonomic and functional profiles were analyzed along with medical histories, serum metabolomics, biometrics, and dietary data. Obesity was associated with alterations in microbiome composition, individual taxa, and functions with notable changes in Akkermansia, Faecalibacterium, Oscillibacter, and Alistipes, as well as in serum metabolites that correlated with gut microbial patterns. However, microbiome associations were modest for T2D, with nominal increases in Escherichia/Shigella. Medications, including antihypertensives and antidiabetics, along with dietary supplements including iron, were significantly associated with microbiome variation. These results differentiate microbial components of these interrelated metabolic diseases and identify dietary and medication exposures to consider in future studies.

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Metadata

Authors
Thingholm, L. B., Rühlemann, M. C., Koch, M., Fuqua, B., Laucke, G., Boehm, R., Bang, C., Franzosa, E. A., Hübenthal, M., Rahnavard, A., Frost, F., Lloyd-Price, J., Schirmer, M., Lusis, A. J., Vulpe, C. D., Lerch, M. M., Homuth, G., Kacprowski, T., Schmidt, C. O., Nöthlings, U., Karlsen, T. H., Lieb, W., Laudes, M., Franke, A., & Huttenhower, C.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2019-08
Volume
26
Issue
2
Pages
252-264.e10
ISSN
1931-3128 (ISSN-L)
DOI
10.1016/j.chom.2019.07.004
OpenAlex
W2964698358
Cited by
451
References
90
FWCI
14.54
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition. https://app.cochat.ai/papers/10.1016/j.chom.2019.07.004
The paper
Thingholm, L. B., Rühlemann, M. C., Koch, M., Fuqua, B., Laucke, G., Boehm, R., Bang, C., Franzosa, E. A., Hübenthal, M., Rahnavard, A., Frost, F., Lloyd-Price, J., Schirmer, M., Lusis, A. J., Vulpe, C. D., Lerch, M. M., Homuth, G., Kacprowski, T., Schmidt, C. O., . . . Huttenhower, C. (2019). Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2019.07.004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.