The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Mechanisms of Oxidative Stress in Metabolic Syndrome
Open accessAbstract
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.
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Citations
Cites
1 retracted
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Cited by
Understanding mechanisms of antioxidant action in health and disease
Halliwell, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00645-4 · Cited by 629
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Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
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Metadata
- Authors
- Masenga, S. K., Kabwe, L. S., Chakulya, M., & Kirabo, A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-04-26
- Volume
- 24
- Issue
- 9
- Pages
- 7898
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4367182956
- Cited by
- 717
- References
- 229
- FWCI
- 70.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- Masenga, S. K., Kabwe, L. S., Chakulya, M., & Kirabo, A. (2023). Mechanisms of Oxidative Stress in Metabolic Syndrome. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms24097898
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
