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Cited by 123Analytical chemistry methods developmentAnalytical Chemistry and ChromatographyMicrofluidic and Capillary Electrophoresis Applications

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Analysis of volatile aldehyde biomarkers in human blood by derivatization and dispersive liquid–liquid microextraction based on solidification of floating organic droplet method by high performance liquid chromatography

Lili, Lv, Xu, Hui, Song, Dandan, Cui, Yanfang, Hu, Sheng, Zhang, Ganbing·2010·Journal of Chromatography A
DOI 10.1016/j.chroma.2010.01.081
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Abstract

A new dispersive liquid-liquid microextraction based on solidification of floating organic droplet method (DLLME-SFO) was developed for the determination of volatile aldehyde biomarkers (hexanal and heptanal) in human blood samples. In the derivatization and extraction procedure, 2,4-dinitrophenylhydrazine (DNPH) as derivatization reagent and formic acid as catalyzer were injected into the sample solution for derivatization with aldehydes, then the formed hydrazones was rapidly extracted by dispersive liquid-liquid microextraction with 1-dodecanol as extraction solvent. After centrifugation, the floated droplet was solidified in an ice bath and was easily removed for analysis. The effects of various experimental parameters on derivatization and extraction conditions were studied, such as the kind and volume of extraction solvent and dispersive solvent, the amount of derivatization reagent, derivatization temperature and time, extraction time and salt effect. The limit of detections (LODs) for hexanal and heptanal were 7.90 and 2.34nmolL(-1), respectively. Good reproducibility and recovery of the method were also obtained. The proposed method is an alternative approach to the quantification of volatile aldehyde biomarkers in complex biological samples, being more rapid and simpler and providing higher sensitivity compared with the traditional dispersive liquid-liquid microextraction (DLLME) methods.

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Metadata

Authors
Lili, L., Xu, H., Song, D., Cui, Y., Hu, S., & Zhang, G.
Affiliations
  • Central China Normal University (CN)
  • Hubei Cancer Hospital (CN)
  • Hubei University (CN)
Corresponding author
  • Xu, Hui
  • Zhang, Ganbing
ORCID
Venue
Journal of Chromatography A
Publisher
Elsevier BV
Published
2010-04
Volume
1217
Issue
16
Pages
2365-2370
ISSN
0021-9673 (ISSN-L)
DOI
10.1016/j.chroma.2010.01.081
OpenAlex
W2093027155
Cited by
123
References
0
Citations by year
2026: 5 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 12 · 2014: 6 · 2013: 20 · 2012: 17
FWCI
18.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Chromatography A (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Keywords
hexanal, heptanal, human blood, dispersive liquid-liquid microextraction, solidification of floating organic droplet, 2,4-dinitrophenylhydrazine derivatization, hydrazones, derivatization optimization, oxidative stress biomarkers
MeSH terms
Aldehydes, Chromatography, High Pressure Liquid, Chemical Fractionation, Humans, Dodecanol, Phenylhydrazines, Sensitivity and Specificity, Sodium Chloride, Solvents, Time, Reproducibility of Results, Linear Models, Volatile Organic Compounds

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