The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: A review
Abstract
The development of novel methods plays a fundamental role in early diagnosis and controlling of neurological disorders (NDs). Blood-brain barrier (BBB) is the most challenging barrier for the development of neuro drug delivery systems due to its inhibiting ability to enter drugs and agents into central nervous system (CNS). Carbon dots (CDs) have shown to be very promising and outstanding agents for various biomedical applications (bio imaging studies, treatment of NDs and brain tumors). They exhibit remarkable properties such as biocompatibility, small size (less than 10 nm, enabling penetration into BBB), tunable optical properties, photostability and simple synthetic procedures, allowing them to act as ideal candidates in various fields of science. Therefore, the objective of this review is to overview the recent studies on CDs for the development of neuro drug delivery systems to reach CNS via crossing of BBB. Primarily, this review briefly outlines the unique optical properties and toxicity of CDs. The development of novel neuro drug delivery systems for various neurological disorders using CDs as carriers is described. This review also covers the potential applications of CDs in brain tumors imaging and treatment of neurodegenerative diseases. Finally, the sensing applications and future prospects of CDs are summarized.
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Cites
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Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease
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Cited by
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
Yusuf, V. F., Malek, N. I., & Kailasa, S. K. (2022) · ACS Omega · doi:10.1021/acsomega.2c05310 · Cited by 894
Self-citationHuang, Y., Guo, X., Wu, Y., Chen, X., Feng, L., Xie, N., & Shen, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01745-z · Cited by 490
Metadata
- Authors
- Ashrafizadeh, M., Mohammadinejad, R., Kailasa, S. K., Ahmadi, Z., Afshar, E. G., & Pardakhty, A.
- Venue
- Advances in Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 278
- Pages
- 102123
- ISSN
- 0001-8686 (ISSN-L)
- OpenAlex
- W3005642348
- Cited by
- 181
- References
- 9
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ashrafizadeh, M., Mohammadinejad, R., Kailasa, S. K., Ahmadi, Z., Afshar, E. G., & Pardakhty, A. (2020). Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: A review. Advances in Colloid and Interface Science. https://doi.org/10.1016/j.cis.2020.102123
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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