Cited by 274Alcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug Metabolism

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Metabolism of Alcohol

Lieber, Charles S.·2005·Clinics in Liver Disease

DOI 10.1016/j.cld.2004.10.005

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Abstract

Most tissues of the body contain enzymes capable of ethanol oxidation or nonoxidative metabolism, but significant activity occurs only in the liver and, to a lesser extent, in the stomach. Hence, medical consequences are predominant in these organs. In the liver, ethanol oxidation generates an excess of reducing equivalents, primarily as NADH, causing hepatotoxicity. An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity.

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Authors: Lieber, C. S.
Affiliations: James J. Peters VA Medical Center (US)
Corresponding author: Lieber, Charles S.
Venue: Clinics in Liver Disease
Publisher: Elsevier BV
Published: 2005-02
Volume: 9
Issue: 1
Pages: 1-35
ISSN: 1089-3261 (ISSN-L)
DOI: 10.1016/j.cld.2004.10.005
OpenAlex: W2045003374
Cited by: 274
References: 293
Citations by year: 2026: 4 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 17 · 2014: 18 · 2013: 11 · 2012: 15
FWCI: 2.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Liver Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: alcohol metabolism, ethanol oxidation, liver, hepatotoxicity, NADH, cytochrome P450, chronic alcohol feeding, liver microsomes, stomach
MeSH terms: Alcohol Oxidoreductases, Ethanol, Alcoholism, Animals, Chronic Disease, Disease Models, Animal, Female, Humans, Liver Diseases, Alcoholic, Male, Microsomes, Liver, Mitochondria, Liver, Prognosis, Severity of Illness Index, Oxidative Stress, Disease Progression, Risk Assessment

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