Mechanisms of drug-induced liver injury

Yuan, Liyun; Kaplowitz, Neil

doi:10.1016/j.cld.2013.07.002

Cited by 322Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathologyDrug-Induced Adverse Reactions

Mechanisms of drug-induced liver injury

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Yuan, Liyun, Kaplowitz, Neil·2013·Clinics in Liver Disease

DOI 10.1016/j.cld.2013.07.002PMC PMC3793205

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Abstract

Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).

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Chronic and/or binge alcohol, high fat diets, tobacco smoking, or certain hepatotoxic drugs can directly damage the mitochondrial ETC, producing greater amounts of ROS leaked from the ETS.
“However, chronic and/or binge alcohol, high fat diets, tobacco smoking, or certain hepatotoxic drugs can directly damage the mitochondrial ETC, producing greater amounts of ROS leaked from the ETS [24], [25], [26], [27].”
From Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications (2014) · cites this paper as [25]

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Authors: Yuan, L., & Kaplowitz, N.
Affiliations: University of Southern California (US)
Corresponding author: Kaplowitz, Neil
ORCID: Yuan, Liyun
Kaplowitz, Neil
Venue: Clinics in Liver Disease
Publisher: Elsevier BV
Published: 2013-11
Volume: 17
Issue: 4
Pages: 507-518
ISSN: 1089-3261 (ISSN-L)
DOI: 10.1016/j.cld.2013.07.002
PMC: PMC3793205
OpenAlex: W2112144522
Cited by: 322
References: 64
Citations by year: 2026: 10 · 2025: 29 · 2024: 21 · 2023: 31 · 2022: 32 · 2021: 38 · 2020: 24 · 2019: 26 · 2018: 25 · 2017: 33 · 2016: 26 · 2015: 17 · 2014: 10
FWCI: 2.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Liver Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067215, P30DK048522)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
Keywords: drug-induced liver injury, hepatocyte death, acetaminophen toxicity, idiosyncratic drug reactions, dose-dependent liver injury, genetic susceptibility, environmental factors, hepatotoxicity mechanisms
MeSH terms: Animals, Humans, Chemical and Drug Induced Liver Injury

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Mechanisms of drug-induced liver injury

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