The DOI matches its Crossref record; 80 of the 81 references it cites were found in a registry or an index.
Immune-microbiota interactions in health and disease
Open accessAbstract
Recent studies have revealed that the intestinal microbiota plays an important role in host physiology and pathophysiology in health and disease. One of the major mechanisms by which the gut microbiota influences the host is through its interactions with and effects on the host immune system. In this review, we discuss the reciprocal interactions between the host immune system and the gut microbiota, with a particular focus on individual microbes that impact the host through dramatic and specific interactions with the adaptive immune system. We highlight the idea that the presence or absence of specific immunologically important members of the microbiota can determine disease susceptibility and propose that the identification and characterization of these bacteria in humans will eventually allow us to elucidate the role of microbiota composition in human disease.
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“A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions.”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [5]
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Items 301–314 of 314
Gapeyev, A. B., Kulagina, T. P., Zhukova, E. S., Aripovsky, A. V., & Pozdnyakova, M. A. (2024) · BIOPHYSICS · doi:10.1134/s0006350924701252
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Gut Microbiota in Colorectal Cancer: Fundamentals, Analytical Techniques, and Its Limitations
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Sensitization to food allergies in the context of atopic comorbidity
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Probiotics and Dietary Recommendations for Rheumatologic Diseases
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Progress in interventions for vaginal microecology
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Metadata
- Authors
- Palm, N. W., de Zoete, M. R., & Flavell, R. A.
- Affiliations
- Yale University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Flavell, Richard A.
- Venue
- Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 159
- Issue
- 2
- Pages
- 122-127
- ISSN
- 1521-6616 (ISSN-L)
- PMC
- PMC4943041
- OpenAlex
- W778562142
- Cited by
- 315
- References
- 81
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 26 · 2023: 30 · 2022: 34 · 2021: 34 · 2020: 33 · 2019: 31 · 2018: 38 · 2017: 22 · 2016: 32 · 2015: 8
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034989, P30DK045735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, host-microbe interactions, adaptive immunity, disease susceptibility, microbiota composition, host immunity
- MeSH terms
- Gastrointestinal Microbiome, B-Lymphocytes, Humans, Immunoglobulin A, Immune System, Immunity, Innate, Inflammation, Intestines, Symbiosis, T-Lymphocytes, Adaptive Immunity
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