Cited by 315Gut microbiota and healthProbiotics and Fermented FoodsOral microbiology and periodontitis research

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Immune-microbiota interactions in health and disease

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Palm, Noah W., de Zoete, Marcel R., Flavell, Richard A.·2015·Clinical Immunology

DOI 10.1016/j.clim.2015.05.014PMC PMC4943041

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Abstract

Recent studies have revealed that the intestinal microbiota plays an important role in host physiology and pathophysiology in health and disease. One of the major mechanisms by which the gut microbiota influences the host is through its interactions with and effects on the host immune system. In this review, we discuss the reciprocal interactions between the host immune system and the gut microbiota, with a particular focus on individual microbes that impact the host through dramatic and specific interactions with the adaptive immune system. We highlight the idea that the presence or absence of specific immunologically important members of the microbiota can determine disease susceptibility and propose that the identification and characterization of these bacteria in humans will eventually allow us to elucidate the role of microbiota composition in human disease.

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Authors: Palm, N. W., de Zoete, M. R., & Flavell, R. A.
Affiliations: Yale University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Flavell, Richard A.
ORCID: Palm, Noah W.
de Zoete, Marcel R.
Flavell, Richard A.
Venue: Clinical Immunology
Publisher: Elsevier BV
Published: 2015-08
Volume: 159
Issue: 2
Pages: 122-127
ISSN: 1521-6616 (ISSN-L)
DOI: 10.1016/j.clim.2015.05.014
PMC: PMC4943041
OpenAlex: W778562142
Cited by: 315
References: 81
Citations by year: 2026: 9 · 2025: 18 · 2024: 26 · 2023: 30 · 2022: 34 · 2021: 34 · 2020: 33 · 2019: 31 · 2018: 38 · 2017: 22 · 2016: 32 · 2015: 8
FWCI: 3.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Utrecht University Repository (Utrecht University) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034989, P30DK045735)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, host-microbe interactions, adaptive immunity, disease susceptibility, microbiota composition, host immunity
MeSH terms: Gastrointestinal Microbiome, B-Lymphocytes, Humans, Immunoglobulin A, Immune System, Immunity, Innate, Inflammation, Intestines, Symbiosis, T-Lymphocytes, Adaptive Immunity

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