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Cited by 36Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersHormonal Regulation and Hypertension

The urinary steroid profile in patients diagnosed with adrenal incidentaloma

Kotłowska, Alicja, Maliński, Edmund, Sworczak, Krzysztof, Kumirska, Jolanta, Stepnowski, Piotr·2009·Clinical Biochemistry
DOI 10.1016/j.clinbiochem.2008.12.027
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Abstract

Objective The aim of this study was to investigate the possible urinary markers of hormonal activity in patients with non-functioning adrenal incidentalomas. In order to evaluate the endocrine activity of aforementioned tumours, urinary steroid metabolite levels were analyzed in samples from patients and controls. Possible blocks in metabolic pathways of the examined hormones were determined by comparing selected urinary steroid metabolite sums and ratios in both groups of interest.Design Urine samples were collected from 20 patients with non-functioning adrenal incidentalomas and from 25 controls matched in terms of age, sex and BMI. Excretion of 19 major urinary steroid metabolites was analyzed by gas chromatography. The results were subjected to statistical analysis.Results In patients with adrenal incidentalomas sum of total urinary cortisol metabolites was significantly increased in respect to the control group. We also observed a shift towards tetrahydrocorticosterone, cortisol and etiocholanolone production in patients. No significant differences in production of other urinary steroid metabolites were noted in patients with adrenal incidentalomas in respect to control group.Conclusions Our data suggests that not only urinary free cortisol but also its metabolite such as tetrahydrocortisol and other steroids including etiocholanolone and corticosterone tetrahydrometabolite might be urinary markers for the endocrine activity of adrenal incidentalomas. Enhanced levels of these urinary steroid metabolites indicate an impairment of 11beta-hydroxysteroid dehydrogenase activity and slightly increased activity of 5beta-reductase in patients with adrenal incidentalomas.

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Crossref · 10.1016/j.clinbiochem.2008.12.027

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  • Twenty-four-hour urine steroid excretion analysis has significant potential in the assessment of adrenal diseases.

    “Twenty-four-hour urine steroid excretion analysis represents a more accurate estimate of total corticosteroid production and of adrenal precursor steroids and metabolites (342, 343) and therefore has significant potential in the assessment of adrenal diseases.”

    From Adrenal incidentaloma (2020) · cites this paper as [343]

  • Twenty-four-hour urine steroid excretion analysis represents a more accurate estimate of total corticosteroid production and of adrenal precursor steroids and metabolites than standard serum measurements.

    “Twenty-four-hour urine steroid excretion analysis represents a more accurate estimate of total corticosteroid production and of adrenal precursor steroids and metabolites (342, 343) and therefore has significant potential in the assessment of adrenal diseases.”

    From Adrenal incidentaloma (2020) · cites this paper as [343]

  • There is a possibility that some patients with "nonsecretory" AIs and distinct urinary steroid patterns could have had an autonomously secreting lesion or a small ACC.

    “There is, therefore, the possibility that some of these patients could have had an autonomously secreting lesion or a small ACC.”

    From Adrenal incidentaloma (2020) · cites this paper as [343]

  • Kotłowska et al. reported that 25% of patients with "nonsecretory" AIs had distinct patterns of urinary steroids compared to controls and other patients with AIs.

    “Interestingly, 25% of patients with “nonsecretory” AIs had distinct patterns of urinary steroids compared to the controls and other patients with AIs.”

    From Adrenal incidentaloma (2020) · cites this paper as [343]

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Authors
Kotłowska, A., Maliński, E., Sworczak, K., Kumirska, J., & Stepnowski, P.
Affiliations
  • University of Gdańsk (PL)
  • Gdańsk Medical University (PL)
Corresponding author
Stepnowski, Piotr
ORCID
Venue
Clinical Biochemistry
Publisher
Elsevier BV
Published
2009-04
Volume
42
Issue
6
Pages
448-454
ISSN
0009-9120 (ISSN-L)
DOI
10.1016/j.clinbiochem.2008.12.027
OpenAlex
W2052276728
Cited by
36
References
31
Citations by year
2026: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Gdański Uniwersytet Medyczny
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
adrenal incidentaloma, urinary steroid metabolites, urinary cortisol metabolites, tetrahydrocortisol, etiocholanolone, corticosterone, 11β-hydroxysteroid dehydrogenase, 5beta-reductase, urinary biomarkers
MeSH terms
Adrenal Gland Neoplasms, Adult, Aged, Chromatography, Gas, Corticosterone, Etiocholanolone, Female, Humans, Hydrocortisone, Male, Middle Aged, Oxidoreductases, Pheochromocytoma, Steroids, Tetrahydrocortisol, Biomarkers, Tumor, 11-beta-Hydroxysteroid Dehydrogenases

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