Cited by 149Clinical Laboratory Practices and Quality ControlAdrenal Hormones and DisordersMetabolomics and Mass Spectrometry Studies

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LC–MS/MS analysis of steroids in the clinical laboratory

Keevil, Brian G.·2016·Clinical Biochemistry

DOI 10.1016/j.clinbiochem.2016.04.009

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Abstract

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful tool that is changing the way we analyse steroids in the clinical laboratory. It is already opening up the field of steroid analysis in endocrinology and is providing new applications for individual steroids and panels of steroids in different clinical conditions. LC-MS/MS is now well-accepted technology and is increasingly being used to replace problematic immunoassay methods because of greater sensitivity and specificity. Improved sample preparation, modern chromatography methods, and sensitive, faster scanning mass spectrometers have all played a role in improving LC-MS/MS. LC-MS/MS is also playing a key role in improving the quality of assays through the development of reference measurement procedures, characterisation of reference materials and multi-site calibration programmes. There is increasing interest in multiplexing steroid assays into panels of diagnostic tests to aid and improve the diagnosis and monitoring of disease.

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Authors: Keevil, B. G.
Affiliations: Manchester Academic Health Science Centre (GB)
Corresponding author: Keevil, Brian G.
ORCID: Keevil, Brian G.
Venue: Clinical Biochemistry
Publisher: Elsevier BV
Published: 2016-09
Volume: 49
Issue: 13-14
Pages: 989-997
ISSN: 0009-9120 (ISSN-L)
DOI: 10.1016/j.clinbiochem.2016.04.009
OpenAlex: W2344158997
Cited by: 149
References: 123
Citations by year: 2026: 13 · 2025: 6 · 2024: 16 · 2023: 16 · 2022: 23 · 2021: 16 · 2020: 18 · 2019: 17 · 2018: 12 · 2017: 11 · 2016: 1
FWCI: 11.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Biochemistry (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords: steroid analysis, LC-MS/MS, laboratory diagnosis, endocrinology, sample preparation, reference measurement procedure, reference materials, multi-site calibration, disease diagnosis and monitoring
MeSH terms: Calibration, Chromatography, Liquid, Humans, Hydrocortisone, Laboratories, Steroids, Tandem Mass Spectrometry

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LC–MS/MS analysis of steroids in the clinical laboratory

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