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Cited by 792Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementDermatologic Treatments and Research

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Impaired wound healing

Menke, Nathan B., Ward, Kevin R., Witten, Tarynn M., Bonchev, Danail G., Diegelmann, Robert F.·2007·Clinics in Dermatology
DOI 10.1016/j.clindermatol.2006.12.005
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Abstract

Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. One of the underlying mechanisms responsible for the failure of chronic wounds to heal is an out-of-control inflammatory response that is self-sustaining. Underappreciation of the inherent complexity of the healing wound has led to the failure of monotherapies, with no significant reduction in wound healing times. A model of the inflammatory profile of a nonhealing wound is one in which the equilibrium between synthesis and degradation has been shifted toward degradation. This review summarizes the current information regarding acute wound healing responses as contrasted to the delayed response characteristic of chronic wounds. In addition, some initial complexity theoretical models are proposed to define and explain the underlying pathophysiology.

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Crossref · 10.1016/j.clindermatol.2006.12.005

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Metadata

Authors
Menke, N. B., Ward, K. R., Witten, T. M., Bonchev, D. G., & Diegelmann, R. F.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Diegelmann, Robert F.
ORCID
Venue
Clinics in Dermatology
Publisher
Elsevier BV
Published
2007-01
Volume
25
Issue
1
Pages
19-25
ISSN
0738-081X (ISSN-L)
DOI
10.1016/j.clindermatol.2006.12.005
OpenAlex
W2043960873
Cited by
792
References
45
Citations by year
2026: 16 · 2025: 38 · 2024: 47 · 2023: 64 · 2022: 49 · 2021: 76 · 2020: 60 · 2019: 38 · 2018: 56 · 2017: 37 · 2016: 51 · 2015: 44 · 2014: 45 · 2013: 36 · 2012: 47
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinics in Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
delayed wound healing, chronic wounds, chronic inflammation, acute wound healing, extracellular matrix degradation, complexity theory, wound healing model
MeSH terms
Acute Disease, Chronic Disease, Humans, Inflammation, Models, Theoretical, Skin, Skin Ulcer, Wound Healing, Wounds, Penetrating, Treatment Failure

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